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N-acetylneuraminic acid synthase

S as, sialic acid synthase
This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, sialyltransferase, PrP, CD45
Papers on S as
Comparison of backbone dynamics of the type III antifreeze protein and antifreeze-like domain of human sialic acid synthase.
Lee et al., Chinju, South Korea. In J Biomol Nmr, Feb 2015
Sialic acids play important roles in a variety of biological functions, such as development, recognition, and cell adhesion and are synthesized by conserved enzymatic pathways that include sialic acid synthase (SAS).
Probing the determinants of phosphorylated sugar-substrate binding for human sialic acid synthase.
Parker et al., Christchurch, New Zealand. In Biochim Biophys Acta, 2014
Prokaryotic NeuNAc biosynthesis proceeds via condensation of phosphoenolpyruvate (PEP) with N-acetylmannosamine (ManNAc), a reaction catalysed by the domain-swapped homodimeric enzyme, N-acetylneuraminic acid synthase (NeuNAcS).
Characterization of the sialic acid synthase from Aliivibrio salmonicida suggests a novel pathway for bacterial synthesis of 7-O-acetylated sialic acids.
Smalås et al., Tromsø, Norway. In Glycobiology, 2013
Resolving the enzymatic pathways leading to sialic acids (Sias) in bacteria are vitally important for understanding their roles in pathogenesis and for subsequent development of tools to combat infections.
Attenuation of Streptococcus suis virulence by the alteration of bacterial surface architecture.
Wang et al., Nanjing, China. In Sci Rep, 2011
NeuB, a sialic acid synthase catalyzes the last committed step of the de novo biosynthetic pathway of sialic acid, a major element of bacterial surface structure.
DmSAS is required for sialic acid biosynthesis in cultured Drosophila third instar larvae CNS neurons.
Recio-Pinto et al., New York City, United States. In Acs Chem Biol, 2011
Here we investigated whether sialic acid incorporation in cultured Dm central nervous system (CNS) neurons required endogenously expressed Dm sialic acid synthase (DmSAS).
Use of the accessory genome for characterization and typing of Acinetobacter baumannii.
Perry et al., London, United Kingdom. In J Clin Microbiol, 2011
Detection, or not, of each element sought provided some degree of discrimination among the set, with the presence or absence of genes coding for a phage terminase (ACICU_02185), a sialic acid synthase (ACICU_00080), a polysaccharide biosynthesis protein (AB57_0094), aphA1, bla(TEM), and integron-associated orfX (Kyoto Encyclopedia of Genes and Genomes [KEGG] no.
Evolution of an antifreeze protein by neofunctionalization under escape from adaptive conflict.
Chen et al., Beijing, China. In Proc Natl Acad Sci U S A, 2011
We report here clear experimental evidence for EAC-driven evolution of type III antifreeze protein gene from an old sialic acid synthase (SAS) gene in an Antarctic zoarcid fish.
Identification of up- and down-regulated proteins in gemcitabine-resistant pancreatic cancer cells using two-dimensional gel electrophoresis and mass spectrometry.
Nakamura et al., Ube, Japan. In Anticancer Res, 2010
The up-regulated proteins include acidic leucine-rich nuclear phosphoprotein 32 family member A, reticulocalbin-1, gamma-synuclein, microtubule-associated protein RP/EB family, sialic acid synthase, peptidyl-prolyl cis-trans isomerase A, far upstream element-binding protein 2 and catalase.
Inhibition of Neisseria meningitidis sialic acid synthase by a tetrahedral intermediate analogue.
Tanner et al., Vancouver, Canada. In Biochemistry, 2009
The Neisseria meningitidis sialic acid synthase (NeuB) catalyzes the metal-dependent condensation of N-acetylmannosamine (ManNAc) and phosphoenolpyruvate (PEP) to generate N-acetylneuraminic acid (NeuAc or sialic acid).
Comparative structural studies of psychrophilic and mesophilic protein homologues by molecular dynamics simulation.
Roy et al., Calcutta, India. In J Mol Graph Model, 2009
Comparative molecular dynamics simulations of psychrophilic type III antifreeze protein from the North-Atlantic ocean-pout Macrozoarces americanus and its corresponding mesophilic counterpart, the antifreeze-like domain of human sialic acid synthase, have been performed for 10 ns each at five different temperatures.
Enhanced sialylation of recombinant erythropoietin in genetically engineered Chinese-hamster ovary cells.
Kim et al., Taejŏn, South Korea. In Biotechnol Appl Biochem, 2009
To enhance EPO sialylation, we introduced human alpha2,3-ST (alpha2,3-sialyltransferase) and CMP-SAS (CMP-sialic acid synthase) into recombinant human EPO-producing CHO cells.
Campylobacter jejuni response to human mucin MUC2: modulation of colonization and pathogenicity determinants.
Mendz et al., Sydney, Australia. In J Med Microbiol, 2008
The genes encoding cytolethal distending toxin protein (cdtABC), vacuolating cytotoxin (vacB), C. jejuni lipoprotein (jlpA), Campylobacter invasion antigen (ciaB), the multidrug efflux system (cmeAB), putative mucin-degrading enzymes (cj1344c, cj0843c, cj0256 and cj1055c), flagellin A (flaA) and putative rod-shape-determining proteins (mreB and mreC) were upregulated, whereas those encoding Campylobacter adhesion fibronectin-binding protein (cadF) and sialic acid synthase (neuB1) were downregulated.
Genetic engineering of Escherichia coli for the economical production of sialylated oligosaccharides.
Samain et al., Grenoble, France. In J Biotechnol, 2008
Mutant strains devoid of Neu5Ac aldolase and of ManNAc kinase were shown to efficiently produce 3'sialyllactose by coexpressing the alpha-2,3-sialyltransferase gene from Neisseria meningitidis with the neuC, neuB and neuACampylobacter jejuni genes encoding N-acetylglucosamine-6-phosphate-epimerase, sialic acid synthase and CMP-Neu5Ac synthetase, respectively.
Identification of the nuclear export signals that regulate the intracellular localization of the mouse CMP-sialic acid synthetase.
Kitajima et al., Nagoya, Japan. In Biochem Biophys Res Commun, 2007
Intracellular localization of this enzyme is regulated not only due to the nuclear localization signal but also two nuclear export signals.
Manifold decrease of sialic acid synthase in fetal Down syndrome brain.
Lubec et al., Vienna, Austria. In Amino Acids, 2007
AIMS: As sialylation of glycoconjugates plays an important role in brain development, this study aimed to look at the sialic acid metabolism by measuring sialic acid synthase (SAS; N-acetylneuraminate synthase) in early second trimester fetal control and DS brain.
Solution structure of the antifreeze-like domain of human sialic acid synthase.
Hirota et al., Yokohama, Japan. In Protein Sci, 2006
The structure of the C-terminal antifreeze-like domain of human sialic acid synthase was determined. The structure comprises one alpha- and two single-turn 3(10)-helices and two beta-strands, and is similar to those of the type III antifreeze proteins.
Cloning, expression, and characterization of sialic acid synthases.
Sundaramoorthy et al., Nashville, United States. In Biochem Biophys Res Commun, 2006
sialic acid synthases kinetics and preliminary mutagenesis experiments reveal the importance of C-terminal antifreeze protein domain
The enzymes of sialic acid biosynthesis.
Tanner, Vancouver, Canada. In Bioorg Chem, 2005
The first, a hydrolyzing UDP-N-acetylglucosamine 2-epimerase, generates N-acetylmannosamine and UDP from UDP-N-acetylglucosamine. The second, sialic acid synthase, generates either N-acetylneuraminic acid (bacteria) or N-acetylneuraminic acid 9-phosphate (mammals) in a condensation reaction with phosphoenolpyruvate.
Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma.
Benassi et al., Bologna, Italy. In Histol Histopathol, 2004
CDK4, MDM2, SAS and GLI genes are amplified in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma
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