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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Ryanodine receptor 3

The protein encoded by this gene is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. For example, the encoded protein is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: RyR2, CAN, V1a, HAD, ACID
Papers on RyR3
miR-367 promotes proliferation and stem-like traits in medulloblastoma cells.
Okamoto et al., São Paulo, Brazil. In Cancer Sci, Sep 2015
A concurrent downregulation of the miR-367 cancer-related targets RYR3, ITGAV and RAB23, was also detected in miR-367-overexpressing cells.
Both RyRs and TPCs are required for NAADP-induced intracellular Ca²⁺ release.
Gerasimenko et al., Wako, Japan. In Cell Calcium, Sep 2015
In RyR3-KO, NAADP-evoked Ca(2+) release reduced by ∼50% but, when combined with antibodies against RyR1, responses were 90% inhibited.
The role of Ca(2+) influx in spontaneous Ca(2+) wave propagation in interstitial cells of Cajal from the rabbit urethra.
Sergeant et al., Dún Dealgan, Ireland. In J Physiol, Sep 2015
RT-PCR revealed that isolated ICC expressed both RyR2 and RyR3 subtypes.
Structural and functional properties of ryanodine receptor type 3 in zebrafish tail muscle.
Franzini-Armstrong et al., Philadelphia, United States. In J Gen Physiol, Mar 2015
A second isoform, RyR3, does not sustain EC coupling and differentiation in the absence of RyR1 and is expressed at highly variable levels.
Deep sequencing of RYR3 gene identifies rare and common variants associated with increased carotid intima-media thickness (cIMT) in HIV-infected individuals.
Shrestha et al., Birmingham, United States. In J Hum Genet, Feb 2015
The ryanodine receptor 3 gene (RYR3) has previously been linked to increased cIMT; however, the causal variants have not yet been localized.
Blood brain barrier precludes the cerebral arteries to intravenously-injected antisense oligonucleotide.
Morel et al., Bordeaux, France. In Eur J Pharmacol, Feb 2015
Alternative splicing of the ryanodine receptor subtype 3 (RyR3) produces a short isoform (RyR3S) able to negatively regulate the ryanodine receptor subtype 2 (RyR2), as shown in cultured smooth muscle cells from mice.
A polymorphism at the microRNA binding site in the 3' untranslated region of RYR3 is associated with outcome in hepatocellular carcinoma.
Zhang et al., Shijiazhuang, China. In Onco Targets Ther, 2014
In this study, three microRNA binding site single nucleotide polymorphisms (SNPs) located in the 3' UTR of RYR3 (rs1044129), C14orf101 (rs4901706), and KIAA0423 (rs1053667) were genotyped to assess their relationships with the risks and outcomes of hepatocellular carcinoma (HCC).
Chronic fetal exposure to caffeine altered resistance vessel functions via RyRs-BKCa down-regulation in rat offspring.
Xu et al., Suzhou, China. In Sci Rep, 2014
Reduced RyR1 was greater than that of RyR3.
Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.
Marks et al., New York City, United States. In Curr Mol Pharmacol, 2014
The ryanodine receptors (RyRs: RyR1, RyR2, RyR3) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1, IP3R2, IP3R3) are the major Ca(2+) release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR).
Pre-Slaughter Stress Affects Ryanodine Receptor Protein Gene Expression and the Water-Holding Capacity in Fillets of the Nile Tilapia.
Ribeiro et al., Maringá, Brazil. In Plos One, 2014
Current study evaluated the effect of pre-slaughter stress on serum cortisol levels, pH, colorimetry, water-holding capacity (WHC) and gene expression of ryanodine receptors (RyR1 and RyR3) in the Nile tilapia.
Ryanodine receptors are targeted by anti-apoptotic Bcl-XL involving its BH4 domain and Lys87 from its BH3 domain.
Bultynck et al., Leuven, Belgium. In Sci Rep, 2014
Here, Bcl-XL co-immunoprecipitated with RyR3 expressed in HEK293 cells.
Genetic findings in obsessive-compulsive disorder connect to brain-derived neutrophic factor and mammalian target of rapamycin pathways: implications for drug development.
Srivastava et al., Baltimore, United States. In Drug Dev Res, 2014
The OCD susceptibility genes DLGAP1, RYR3, PBX1-MEIS2, LMX1A and candidate genes BDNF and GRIN2B are components of the neuronal growth, differentiation and neurogenesis pathways BDNF-mTOR.
Glutamate drugs and pharmacogenetics of OCD: a pathway-based exploratory approach.
Fortune et al., Baltimore, United States. In Expert Opin Drug Discov, 2013
Furthermore, recent genetic epidemiology research findings are presented with a focus on the positional candidate genes SLC1A1 (a glutamate transporter), ADAR3 (an RNA-editing enzyme), RYR3 (a Ca(2+) channel), PBX1 (a homeobox transcription factor) and a GWAS candidate gene, DLGAP1 (a protein interacting with post-synaptic density).
Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.
Stutzmann et al., North Chicago, United States. In Neurobiol Aging, 2012
Alterations in RyR3 expression at early disease stages may reflect the onset of pathologic mechanisms leading to later neurodegeneration.
Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.
Park et al., Inch'ŏn, South Korea. In Arch Biochem Biophys, 2012
The study provides biochemical evidence of the interaction between FKBP12 and RYR1, RYR3 and IP3R.
Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.
Denda et al., Yokohama, Japan. In J Invest Dermatol, 2012
RyR expressed in epidermal keratinocytes is associated with both differentiation of keratinocytes and epidermal barrier homeostasis.
Functional SNP in the microRNA-367 binding site in the 3'UTR of the calcium channel ryanodine receptor gene 3 (RYR3) affects breast cancer risk and calcification.
Chen et al., Tianjin, China. In Proc Natl Acad Sci U S A, 2011
A putative binding site for microRNA-367 exists in the 3'UTR of RYR3, and a genetic variant, rs1044129 A-->G, is present in this binding region.
Two ryanodine receptor isoforms in nonmammalian vertebrate skeletal muscle: possible roles in excitation-contraction coupling and other processes.
Kurebayashi et al., Tokyo, Japan. In Prog Biophys Mol Biol, 2011
Whereas mammalian skeletal muscle predominantly expresses a single RyR isoform, RyR1, skeletal muscle of many nonmammalian vertebrates expresses equal amounts of two distinct isoforms, α-RyR and β-RyR, which are homologues of mammalian RyR1 and RyR3, respectively.
Association between statin-associated myopathy and skeletal muscle damage.
Draeger et al., Bern, Switzerland. In Cmaj, 2009
Upregulation of the expression of ryanodine receptor 3 is suggestive of an intracellular calcium leak.
The non-excitable smooth muscle: calcium signaling and phenotypic switching during vascular disease.
Trebak et al., Albany, United States. In Pflugers Arch, 2008
The expression levels of intracellular Ca(2+) release channels, pumps and Ca(2+)-activated proteins are also altered: the proliferative VSMC lose the RyR3 and the sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase isoform 2a pump and reciprocally regulate isoforms of the ca(2+)/calmodulin-dependent protein kinase II.
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