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Runt-related transcription factor 3

RUNX3, Core Binding Factor Alpha 3, AML-2
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, p16, HAD, AML1, POLYMERASE
Papers using RUNX3 antibodies
Increased expression of tissue inhibitor of metalloproteinase-2 in clear cell carcinoma of the ovary.
Creighton Chad, In PLoS ONE, 2002
... Immunohistochemistry was done as described using a rabbit polyclonal antibody against human RUNX3 at a dilution of 1∶200 (Active Motif, Carlsbad, CA) ...
Papers on RUNX3
Genome-Wide Analysis of DNA Methylation and Cigarette Smoking in Chinese.
Wu et al., Wuhan, China. In Environ Health Perspect, Feb 2016
Of these smoking-related CpGs, methylation levels at 80 CpGs showed significant correlations with the expression of corresponding genes (including RUNX3, IL6R, PTAFR, ANKRD11, CEP135 and CDH23), and methylation at 15 CpGs were significantly associated with urinary 2-hydroxynaphthalene, the most representative internal monohydroxy-PAHs biomarker for smoking.
RUNX3 is down-regulated in glioma by Myc-regulated miR-4295.
Liu et al., Shenyang, China. In J Cell Mol Med, Feb 2016
Furthermore, we confirmed miR-4295 mediates the expression of RUNX3 by targeting its 3'untranslation region.
The emerging role of RUNX3 in cancer metastasis (Review).
Zheng et al., Xuzhou, China. In Oncol Rep, Jan 2016
The runt-related transcription factor 3 (RUNX3) is a downstream effector of the transforming growth factor-β (TGF-β) signaling pathway, and has critical roles in the regulation of cell death by apoptosis, and in angiogenesis, epithelial-to-mesenchymal transition (EMT), cell migration and invasion.
Genomic landscape of liposarcoma.
Koeffler et al., Singapore, Singapore. In Oncotarget, Jan 2016
Notable deletions were found at chromosome 1p (RUNX3, ARID1A), chromosome 11q (ATM, CHEK1) and chromosome 13q14.2
Evaluation of CpG Island Methylator Phenotype as a Biomarker in Colorectal Cancer Treated With Adjuvant Oxaliplatin.
Grady et al., Seattle, United States. In Clin Colorectal Cancer, Dec 2015
CIMP status was determined using the DNA methylation status of CACNA1G, IGF2, NEUROG1, RUNX3, and SOCS1.
The immunogenetics of Psoriasis: A comprehensive review.
Bowcock et al., New York City, United States. In J Autoimmun, Nov 2015
These genes span an array of functions that involve antigen presentation (HLA-Cw6, ERAP1, ERAP2, MICA), the IL-23 axis (IL12Bp40, IL23Ap19, IL23R, JAK2, TYK2), T-cell development and T-cells polarization (RUNX1, RUNX3, STAT3, TAGAP, IL4, IL13), innate immunity (CARD14, c-REL, TRAF3IP2, DDX58, IFIH1), and negative regulators of immune responses (TNIP1, TNFAIP3, NFKBIA, ZC3H12C, IL36RN, SOCS1).
Comparison of different PCR primers on detecting arbuscular mycorrhizal communities inside plant roots.
Feng et al., In Wei Sheng Wu Xue Bao, Aug 2015
METHODS: We chose four commonly used AMF-specific primer combinations (NS31-AM1, AMLl-AML2, NS31-AML2 and SSUmCf-LSUmBr), and used 18S rDNA clone libraries to describe the AMF diversity and community.
RUNX3 Controls a Metastatic Switch in Pancreatic Ductal Adenocarcinoma.
Hingorani et al., Seattle, United States. In Cell, Jul 2015
Expression levels of Runx3 respond to and combine with Dpc4 status to coordinately regulate the balance between cancer cell division and dissemination.
How do K-RAS-activated cells evade cellular defense mechanisms?
Bae et al., Ch'ŏngju, South Korea. In Oncogene, Jun 2015
Among the genes involved in K-RAS-induced lung tumorigenesis, RUNX3 is unique: inactivation of Runx3 in mouse lung induces lung adenoma and abrogates the ARF-p53 pathway.
Runx3 at the interface of immunity, inflammation and cancer.
Groner et al., Israel. In Biochim Biophys Acta, Apr 2015
More than a decade ago claims arose that the RUNX3 member of the RUNX transcription factor family is a major TSG inactivated in gastric cancer, a postulate extended later to other cancers.
A systematic review and meta-analysis of runt-related transcription factor 3 gene promoter hypermethylation and risk of gastric cancer.
Liu et al., Nanyang, China. In J Cancer Res Ther, 2014
OBJECTIVE: To evaluate the association between runt-related transcription factor 3 (RUNX3) gene promoter hypermethylation and gastric cancer risk by meta-analysis.
Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma.
Bae et al., Ch'ŏngju, South Korea. In Cancer Cell, 2013
Targeted inactivation of Runx3 in mouse lung induced mucinous and nonmucinous adenomas and markedly shortened latency of adenocarcinoma formation induced by oncogenic K-Ras.
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
Trembath et al., Ann Arbor, United States. In Nat Genet, 2012
The newly identified loci shared with other autoimmune diseases include candidate genes with roles in regulating T-cell function (such as RUNX3, TAGAP and STAT3).
NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.
Weng et al., Vancouver, Canada. In Nat Med, 2012
We also show that PKC-θ is regulated by a new pathway in which NOTCH1 induces runt-related transcription factor 3 (RUNX3), RUNX3 represses RUNX1 and RUNX1 induces PKC-θ.
Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function.
Kaplan et al., Indianapolis, United States. In J Immunol, 2012
Runx3 rescues the inhibitory effect of Twist1 independent of T-box transcription factor (T-bet) and signal transducer and activator of transcription (STAT)4.
RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors.
Ito et al., Singapore, Singapore. In Cell Cycle, 2012
RUNX3 binds to centrosomal protein rootletin.
[Tumor suppressive functions of RUNX3 in gastric carcinogenesis].
Ito, Nagasaki, Japan. In Seikagaku, 2012
It is a tumor suppressive gene for gastric carcinogenesis. (review)
[The associated research on the expression of RUNX3 mRNA and protein in hepatic cell carcinoma as well as the relationship with clinical pathological parameters].
Lin et al., Xiamen, China. In Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi, 2011
The lower expression of runx3 protein in the hepatic cell carcinoma (HCC) probably plays an important role in the tumorigenesis and development of HCC.
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
Wellcome Trust Case Control Consortium 2 (WTCCC2) et al., Bristol, United Kingdom. In Nat Genet, 2011
Here we report the identification of three variants in the RUNX3, LTBR-TNFRSF1A and IL12B regions convincingly associated with ankylosing spondylitis (P < 5 × 10(-8) in the combined discovery and replication datasets) and a further four loci at PTGER4, TBKBP1, ANTXR2 and CARD9 that show strong association across all our datasets (P < 5 × 10(-6) overall, with support in each of the three datasets studied).
Runt-related transcription factor 3 methylation as a possible prognosticator in muscle-invasive bladder cancer.
Kim et al., Ch'ŏngju, South Korea. In Cancer Biomark, 2010
RUNX3 promoter methylation is a significant prognostic factor for overall survival in muscle invasive bladder cancer (MIBC) patients.
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