Pathophysiology of Vascular Calcification.
Indianapolis, United States. In Curr Osteoporos Rep, Dec 2015
The pathogenesis of vascular calcification is complex and involves a transformation of vascular smooth muscle cells to an osteo/chondrocytic cell that expresses RUNX2 and produces matrix vesicles.
Selective regulation of Mmp13 by 1,25(OH)2D3, PTH, and Osterix through distal enhancers.
Madison, United States. In J Steroid Biochem Mol Biol, Oct 2015
These activities occur through participation by the transcription factors VDR, RUNX2, FOS, JUN, and Osterix (OSX), respectively.
Role of RUNX2 in Breast Carcinogenesis.
Łódź, Poland. In Int J Mol Sci, 2014
RUNX2 is a transcription factor playing the major role in osteogenesis, but it can be involved in DNA damage response, which is crucial for cancer transformation.
Los Angeles, United States. In Adv Exp Med Biol, 2014
Future therapeutic approaches may aim at GC targets such as those mentioned above, or newly identified targets including the Notch pathway, the AP-1/Il11 axis and the osteoblast master regulator RUNX2.
Mechanical memory and dosing influence stem cell fate.
Boulder, United States. In Nat Mater, 2014
We found that the activation of the Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding domain (TAZ) as well as the pre-osteogenic transcription factor RUNX2 in human mesenchymal stem cells (hMSCs) cultured on soft poly(ethylene glycol) (PEG) hydrogels (Young's modulus E ~ 2 kPa) depended on previous culture time on stiff tissue culture polystyrene (TCPS; E ~ 3 GPa).
Building strong bones: molecular regulation of the osteoblast lineage.
Saint Louis, United States. In Nat Rev Mol Cell Biol, 2012
In particular, all of the major developmental signals (including WNT and Notch signalling), along with an increasing number of transcription factors (such as RUNX2 and osterix), have been shown to regulate the differentiation and/or function of osteoblasts.
Modulating hedgehog signaling can attenuate the severity of osteoarthritis.
Toronto, Canada. In Nat Med, 2009
Furthermore, we show in mice and in human cartilage explants that pharmacological or genetic inhibition of Hh signaling reduces the severity of osteoarthritis and that runt-related transcription factor-2 (RUNX2) potentially mediates this process by regulating a disintegrin and metalloproteinase with thrombospondin type 1 motif-5 (ADAMTS5) expression.
Differential gene expression patterns and interaction networks in BCR-ABL-positive and -negative adult acute lymphoblastic leukemias.
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Stanford, United States. In J Clin Oncol, 2007
Finally, we constructed a gene expression- and interaction-based outcome predictor consisting of 27 genes (including GRB2, GAB1, GLI1, IRS1, RUNX2, and SPP1), which correlated with overall survival in BCR-ABL-positive adult ALL (P = .0001),