Genomic Study of Cardiovascular Continuum Comorbidity.
Tomsk, Russia. In Acta Naturae, Jul 2015
A total of 14 polymorphic variants were associated with the phenotype "IHD only," including those in the APOB, CD226, NKX2-5, TLR2, DPP6, KLRB1, VDR, SCARB1, NEDD4L, and SREBF2 genes, and intragenic variants rs12487066, rs7807268, rs10896449, and rs944289.
NEDD4-2 and salt-sensitive hypertension.
Lausanne, Switzerland. In Curr Opin Nephrol Hypertens, Mar 2015
SUMMARY: The emerging role of NEDD4-2 in the regulation of different Na+ transporters along the nephron and the identification of human polymorphisms in the NEDD4-2 gene (Nedd4L) related to salt-sensitive hypertension makes this ubiquitin-protein ligase an interesting target for the development of antihypertensive drugs.
NEDD4-2 (NEDD4L): the ubiquitin ligase for multiple membrane proteins.
Adelaide, Australia. In Gene, Mar 2015
NEDD4-2 (also known as NEDD4L, neural precursor cell expressed developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family which is known to bind and regulate a number of membrane proteins to aid in their internalization and turnover.
Regulation of transport across cell membranes by the serum- and glucocorticoid-inducible kinase SGK1.
Tübingen, Germany. In Mol Membr Biol, 2014
Mechanisms employed by SGK1 in transport regulation include direct phosphorylation of target transport proteins, phosphorylation and thus activation of other transport regulating kinases, stabilization of membrane proteins by phosphorylation and thus inactivation of the ubiquitin ligase NEDD4-2, as well as stimulation of transport protein expression by upregulation transcription factors (e.g., nuclear factor kappa-B [NFκB]) and by fostering of protein translation.
Advancing management of hypertension through pharmacogenomics.
Gainesville, United States. In Ann Med, 2012
There are several examples in the literature of genes with relatively strong data on associations of genetic polymorphisms with antihypertensive response; the data on ADRB1, CACNB2, and NEDD4L are detailed as examples.