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RSP5 Rsp5p

Rsp5, Nedd4-2, Rsp5p, NEDD4L
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] (from NCBI)
Top mentioned proteins: Ubiquitin, Nedd4, CAN, ACID, V1a
Papers using Rsp5 antibodies
The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo
Hicke Linda et al., In The Journal of Cell Biology, 2000
... GFP-RSP5 chimera was constructed by ligating a NotI–GFP fragment, generated by PCR amplification of a plasmid encoding GFP (BD Biosciences) with oligonucleotides containing flanking ...
Papers on Rsp5
Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor-β (TGF-β)/Smad Signaling.
Chen et al., Beijing, China. In J Biol Chem, Feb 2016
Mechanistically, Smad7 competes with Smad4 to associate with R-Smads and recruits the E3 ubiquitin ligase NEDD4L to activated R-Smads, leading to their polyubiquitination and proteasomal degradation.
Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR.
Jansson et al., London, Canada. In Clin Sci (lond), Dec 2015
The activity of mTORC1 and mTORC2 was decreased whereas the protein expression of the ubiquitin ligase NEDD4-2 (neural precursor cell expressed developmentally down-regulated protein 4-2; +72%, P<0.0001) and the ubiquitination of SNAT-2 (+180%, P<0.05) were increased in homogenates of IUGR placentas.
Nedd4L expression is decreased in ovarian epithelial cancer tissues compared to ovarian non-cancer tissue.
Han et al., Changchun, China. In J Obstet Gynaecol Res, Dec 2015
AIM: Recent studies have demonstrated that the neural precursor cell expressed, developmentally downregulated 4-like (Nedd4L) gene plays a role in the progression of various cancers.
Mimicking the phosphorylation of Rsp5 in PKA site T761 affects its function and cellular localization.
Zoladek et al., Warsaw, Poland. In Eur J Cell Biol, Dec 2015
Rsp5 ubiquitin ligase belongs to the Nedd4 family of proteins, which affect a wide variety of processes in the cell.
Cold Temperature Induces the Reprogramming of Proteolytic Pathways in Yeast.
Crosas et al., Spain. In J Biol Chem, Dec 2015
We have observed that a large group of proteins showing increased ubiquitylation in the proteasome mutant at low temperature is comprised by Reverses SPT-Phenotype 5 (RSP5)-regulated plasma membrane proteins.
miR-93 promotes TGF-β-induced epithelial-to-mesenchymal transition through downregulation of NEDD4L in lung cancer cells.
Wang et al., Weifang, China. In Tumour Biol, Dec 2015
Here, we report that a previously unidentified target of miR-93, neural precursor cell expressed developmentally downregulated gene 4-like (NEDD4L), is able to mediate TGF-β-mediated EMT in lung cancer cells.
Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes.
Trejo et al., San Diego, United States. In J Cell Biol, Oct 2015
Activated PAR1 K63-linked ubiquitination is mediated by the NEDD4-2 E3 ubiquitin ligase and initiated recruitment of transforming growth factor-β-activated protein kinase-1 binding protein-2 (TAB2).
Genomic Study of Cardiovascular Continuum Comorbidity.
Puzyrev et al., Tomsk, Russia. In Acta Naturae, Jul 2015
A total of 14 polymorphic variants were associated with the phenotype "IHD only," including those in the APOB, CD226, NKX2-5, TLR2, DPP6, KLRB1, VDR, SCARB1, NEDD4L, and SREBF2 genes, and intragenic variants rs12487066, rs7807268, rs10896449, and rs944289.
NEDD4-2 and salt-sensitive hypertension.
Staub et al., Lausanne, Switzerland. In Curr Opin Nephrol Hypertens, Mar 2015
SUMMARY: The emerging role of NEDD4-2 in the regulation of different Na+ transporters along the nephron and the identification of human polymorphisms in the NEDD4-2 gene (Nedd4L) related to salt-sensitive hypertension makes this ubiquitin-protein ligase an interesting target for the development of antihypertensive drugs.
Integrated molecular analysis to investigate the role of microRNAs in pancreatic tumour growth and progression.
Jiao et al., Roma, Italy. In Lancet, Mar 2015
FINDINGS: We identified three miRNAs (miR-21, miR-23a, and miR-27a) that acted as cooperative repressors of a network of tumour suppressor genes that included PDCD4, BTG2, and NEDD4L.
NEDD4-2 (NEDD4L): the ubiquitin ligase for multiple membrane proteins.
Kumar et al., Adelaide, Australia. In Gene, Mar 2015
NEDD4-2 (also known as NEDD4L, neural precursor cell expressed developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family which is known to bind and regulate a number of membrane proteins to aid in their internalization and turnover.
Regulation of transport across cell membranes by the serum- and glucocorticoid-inducible kinase SGK1.
Alesutan et al., Tübingen, Germany. In Mol Membr Biol, 2014
Mechanisms employed by SGK1 in transport regulation include direct phosphorylation of target transport proteins, phosphorylation and thus activation of other transport regulating kinases, stabilization of membrane proteins by phosphorylation and thus inactivation of the ubiquitin ligase NEDD4-2, as well as stimulation of transport protein expression by upregulation transcription factors (e.g., nuclear factor kappa-B [NFκB]) and by fostering of protein translation.
Mineralocorticoid-induced sodium appetite and renal salt retention: evidence for common signaling and effector mechanisms.
Vallon et al., San Diego, United States. In Nephron Physiol, 2013
We discuss the working hypothesis that aldosterone activates similar signaling and effector mechanisms in the kidney and brain, including the mineralocorticoid receptor, the serum- and glucocorticoid-induced kinase SGK1, the ubiquitin ligase NEDD4-2, and the epithelial sodium channel ENaC.
De novo mutations in epileptic encephalopathies.
Winawer et al., In Nature, 2013
Other genes with de novo mutations in this cohort include CACNA1A, CHD2, FLNA, GABRA1, GRIN1, GRIN2B, HNRNPU, IQSEC2, MTOR and NEDD4L.
The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation.
Yu et al., Shanghai, China. In Biochem J, 2012
Three members of Nedd4 (neural-precursor-cell-expressed developmentally down-regulated)-like ubiquitin E3 ligases, Nedd4, Nedd4-2 and Itch were identified, as the ubiquitin E3 ligases for the long isoform of AMOT, AMOT/p130.
Protein kinase C (PKC)-promoted endocytosis of glutamate transporter GLT-1 requires ubiquitin ligase Nedd4-2-dependent ubiquitination but not phosphorylation.
Zafra et al., Madrid, Spain. In J Biol Chem, 2012
GLT-1 endocytosis is independent of its phosphorylation and that Nedd4-2 mediates PKC-dependent down-regulation of the transporter.
Advancing management of hypertension through pharmacogenomics.
Johnson, Gainesville, United States. In Ann Med, 2012
There are several examples in the literature of genes with relatively strong data on associations of genetic polymorphisms with antihypertensive response; the data on ADRB1, CACNB2, and NEDD4L are detailed as examples.
Down-regulation of Nedd4L is associated with the aggressive progression and worse prognosis of malignant glioma.
Tu et al., Xi'an, China. In Jpn J Clin Oncol, 2012
expression of Nedd4L is down-regulated in human gliomas.
The high-affinity choline transporter CHT1 is regulated by the ubiquitin ligase Nedd4-2.
Haga et al., Tokyo, Japan. In Biomed Res, 2012
Nedd4-2 mediated ubiquitination regulates the cell surface expression of CHT1 in HEK293 cells.
Yeast Rsp5 ubiquitin ligase affects the actin cytoskeleton in vivo and in vitro.
Zoladek et al., Warsaw, Poland. In Eur J Cell Biol, 2011
Rsp5 together with Lsb1, Lsb2 and Sla1 regulate the level of Las17, an important activator of actin polymerization.
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