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Ribosomal protein S6 kinase, 52kDa, polypeptide 1

RPK118, SPHK1-binding protein, RPS6KC1, ribosomal protein S6 kinase S6K1
Top mentioned proteins: p70S6K, 4E-BP1, PI3K, SET, Akt
Papers on RPK118
Mutational profiling of kinases in glioblastoma.
Bardelli et al., Torino, Italy. In Bmc Cancer, 2013
Somatic mutations were found in TP53, PTEN, IDH1, PIK3CA, EGFR, BRAF, EPHA3, NRAS, TGFBR2, FLT3 and RPS6KC1.
Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer.
Mills et al., Houston, United States. In Genome Res, 2012
Our results revealed 12 potential driver cancer genes including 10 tumor-suppressor candidates (ARID1A, INHBA, KMO, TTLL5, GRM8, IGFBP3, AKTIP, PHKA2, TRPS1, and WNT11) and two oncogene candidates (ERBB3 and RPS6KC1).
RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains.
Yu et al., Shanghai, China. In Mol Cells, 2005
findings indicate that RPK118 is a PRDX3-binding protein that may be involved in transporting PRDX3 from the cytoplasm to its mitochondrial site of function or to other membrane structures via endosome trafficking.
Regulation of global and specific mRNA translation by oral administration of branched-chain amino acids.
Jefferson et al., United States. In Biochem Biophys Res Commun, 2004
These proteins, eukaryotic initiation factor eIF4E binding protein (4E-BP)1 and ribosomal protein S6 kinase S6K1, control in part the step in translation initiation involving the binding of mRNA to the 40S ribosomal subunit.
The identification of a conserved domain in both spartin and spastin, mutated in hereditary spastic paraplegia.
Crosby et al., Heidelberg, Germany. In Genomics, 2003
The domain, which corresponds to a slightly extended version of the recently described ESP domain of unknown function, was also identified in VPS4, SKD1, RPK118, and SNX15, all of which have a well established and consistent role in endosomal trafficking.
Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein.
Nakamura et al., Kōbe, Japan. In J Biol Chem, 2002
cloning and characterization of RPK118 as a sphingosine kinase-1-binding protein
Control of protein synthesis by amino acid availability.
Jefferson et al., United States. In Curr Opin Clin Nutr Metab Care, 2002
Leucine mediated signaling results in a stimulation of initiation of mRNA translation and involves increases in the phosphorylation status of the translational repression 4E-BP1 and the ribosomal protein S6 kinase S6K1.
Regulation of protein synthesis by branched-chain amino acids.
Jefferson et al., United States. In Curr Opin Clin Nutr Metab Care, 2001
In this role, they modulate the phosphorylation state of proteins that represent important control points in translation initiation, including the translational repressor 4E-BP1 and the ribosomal protein S6 kinase S6K1.
Cloning, characterization, and chromosome mapping of RPS6KC1, a novel putative member of the ribosome protein S6 kinase family, to chromosome 12q12-q13.1.
Zhao et al., Shanghai, China. In Genomics, 1999
A novel cDNA encoding a putative Ser/Thr protein kinase was isolated from a human skeletal muscle cDNA library.
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