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POU class 6 homeobox 2

Rpf1, POU6F2, hRPF1, WT5, Rpf1p
This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, Ubiquitin, ACID, POLYMERASE
Papers on Rpf1
Search for regulatory factors of the pituitary-specific transcription factor PROP1 gene.
Kato et al., Japan. In J Reprod Dev, Jan 2016
Reporter assays for another 39 factors using the 3 kb upstream regions in CHO cells ultimately revealed that 8 factors, MSX2, PAX6, PIT1, PITX1, PITX2, RPF1, SOX8 and SOX11, but not RBP-J, regulate Prop1 expression.
Zinc-binding domain-dependent, deaminase-independent actions of apolipoprotein B mRNA-editing enzyme, catalytic polypeptide 2 (Apobec2), mediate its effect on zebrafish retina regeneration.
Goldman et al., Ann Arbor, United States. In J Biol Chem, 2014
By identifying Apobec2-interacting proteins, including ubiquitin-conjugating enzyme 9 (Ubc9); topoisomerase I-binding, arginine/serine-rich, E3 ubiquitin protein ligase (Toporsa); and POU class 6 homeobox 2 (Pou6f2), we uncovered that sumoylation regulates Apobec2 subcellular localization and that nuclear Apobec2 controls Pou6f2 binding to DNA.
Molecular cloning of rat and porcine retina-derived POU domain factor 1 (POU6F2) from a pituitary cDNA library.
Kato et al., Japan. In J Reprod Dev, 2013
During molecular cloning with the Yeast One-Hybrid System using a 5'-upstream region of the porcine Fshβ as a bait sequence, we have cloned a cDNA encoding a partial sequence of the retina-derived POU domain factor 1 (RPF1) from the porcine pituitary cDNA library and confirmed its specific binding to the bait sequence.
RNA PROCESSING FACTOR3 is crucial for the accumulation of mature ccmC transcripts in mitochondria of Arabidopsis accession Columbia.
Binder et al., Ulm, Germany. In Plant Physiol, 2011
RNA PROCESSING FACTOR1 (RPF1) and RPF2 are pentatricopeptide repeat (PPR) proteins involved in 5' processing of different mitochondrial mRNAs in Arabidopsis (Arabidopsis thaliana).
The epithelial mesenchymal transition process in wilms tumor: a study based on a xenograft model.
Llombart-Bosch et al., Valencia, Spain. In Appl Immunohistochem Mol Morphol, 2011
The genetic studies also showed a WT5 deletion and a MYCN gain in all the tumor samples in passage 4 and beyond, but did not show E-cadherin, β-catenin, and APC mutations.
A RESTORER OF FERTILITY-like PPR gene is required for 5'-end processing of the nad4 mRNA in mitochondria of Arabidopsis thaliana.
Forner et al., Ulm, Germany. In Plant J, 2011
This nuclear gene, At1g12700, that we designate RNA PROCESSING FACTOR 1 (RPF1), encodes a pentatricopeptide repeat (PPR) protein of the P-class containing canonical PPR-repeats.
A genome-wide scan for common alleles affecting risk for autism.
Hallmayer et al., Dublin, Ireland. In Hum Mol Genet, 2010
They did, however, yield strong signals within several genes, KIAA0564, PLD5, POU6F2, ST8SIA2 and TAF1C.
Gain of MYCN region in a Wilms tumor-derived xenotransplanted cell line.
Llombart-Bosch et al., Valencia, Spain. In Diagn Mol Pathol, 2010
The multiplex ligation-dependent probe amplification detected a nondeleted status of genes located close to WT genes, except for a deletion of the EGFR gene (located at 7p11.2) and the GHRHR gene (located at 7p15), both flanking the WT5 gene.
The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men.
Okudan et al., Konya, Turkey. In J Strength Cond Res, 2010
Mean power increased only with CoQ10 supplementation during the WT5.
Transcriptomic signature of cell lines isolated from canine mammary adenocarcinoma metastases to lungs.
Motyl et al., Warsaw, Poland. In J Appl Genet, 2009
These differently expressed genes are involved mainly in signal transduction, cell structure and motility, nucleic acid metabolism, developmental processing, and apoptosis (GHSR, RASSF1, ARF1GAP, WDR74, SMOC2, SFRP4, DIAPH1, FSCN1, ALX4, SNX15, PLD2, WNT7B, POU6F2, NKG7, and POLR2F).
In vitro differentiation of retinal ganglion-like cells from embryonic stem cell derived neural progenitors.
James et al., Thiruvananthapuram, India. In Biochem Biophys Res Commun, 2009
These cells expressed RGC regulators and markers such as, Ath5, Brn3b, RPF-1, Thy-1 and Islet-1, confirming their potential to differentiate into RGCs.
The murine Pou6f2 gene is temporally and spatially regulated during kidney embryogenesis and its human homolog is overexpressed in a subset of Wilms tumors.
Perotti et al., Milano, Italy. In J Pediatr Hematol Oncol, 2006
We have previously suggested the transcription factor gene POU6F2 as a novel tumor suppressor involved in Wilms tumor (WT) predisposition.
A FRET-based approach to ratiometric fluorescence detection of hydrogen peroxide.
Chang et al., Berkeley, United States. In J Am Chem Soc, 2006
We report the synthesis, properties, and biological applications of Ratio-Peroxyfluor-1 (RPF1), a new ratiometric fluorescent reporter for hydrogen peroxide.
Kap120 functions as a nuclear import receptor for ribosome assembly factor Rpf1 in yeast.
Schlenstedt et al., Homburg, Germany. In Mol Cell Biol, 2006
KAP120 functions as a nuclear import receptor for ribosome assembly factor RPF1.
Germline mutations of the POU6F2 gene in Wilms tumors with loss of heterozygosity on chromosome 7p14.
Radice et al., Milano, Italy. In Hum Mutat, 2004
observations suggest that POU6F2 is a tumor suppressor and is involved in hereditary predisposition to Wilms tumor
Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functions.
O'Malley et al., Houston, United States. In J Steroid Biochem Mol Biol, 1999
Other nuclear receptor coactivators include a member of the SWI/SNF complex, BRG-1, which couples ATP hydrolysis to chromatin remodelling, and the E3 ubiquitin-protein ligases E6-AP and RPF-1.
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