Cornelia de Lange syndrome.
Copenhagen, Denmark. In Clin Genet, Jul 2015
To date five genes [NIPBL (Nipped-B-like protein), SMC1A (structural maintenance of chromosomes 1A), SMC3 (structural maintenance of chromosomes 3), RAD21 (human homolog of Schizosaccharomyces pombe radiation sensitive mutant 21) and HDAC8 (histone deacetylase 8)] have been associated with CdLS and mutations of these genes comprise the underlying defect in 70% of the patients.
HDAC8: a multifaceted target for therapeutic interventions.
Freiburg, Germany. In Trends Pharmacol Sci, Jul 2015
Histone deacetylase 8 (HDAC8) is a class I histone deacetylase implicated as a therapeutic target in various diseases, including cancer, X-linked intellectual disability, and parasitic infections.
Mysteries of metals in metalloenzymes.
Los Angeles, United States. In Acc Chem Res, 2014
For example, histone deacetylase 8 naturally operates with Zn(2+) in the active site but becomes much more active with Fe(2+).