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RPO26 Rpo26p

RPB6, RPO26, ABC23, POLR2F, hRPB14.4
This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes, that is also shared by the other two DNA-directed RNA polymerases. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: POLYMERASE, Rpb1, ACID, CAN, Rpb7
Papers on RPB6
Two Routes to Genetic Suppression of RNA Trimethylguanosine Cap Deficiency via C-Terminal Truncation of U1 snRNP Subunit Snp1 or Overexpression of RNA Polymerase Subunit Rpo26.
Shuman et al., New York City, United States. In G3 (bethesda), Jul 2015
We thereby recovered RPO26 (encoding a shared subunit of all three nuclear RNA polymerases) and RPO31 (encoding the largest subunit of RNA polymerase III) as moderate and weak suppressors of tgs1∆ cold sensitivity, respectively.
Identification of new hub genes associated with bladder carcinoma via bioinformatics analysis.
Gao et al., Beijing, China. In Tumori, 2015
The top 10 highest degree nodes, such as POLR2F/2H (DNA directed RNA polymerase II polypeptide F/polypeptide H) and RPS14/15 (ribosomal protein S14/S15), were proven to be hub nodes in the PPIs network.
Distinguishing between cancer cell differentiation and resistance induced by all-trans retinoic acid using transcriptional profiles and functional pathway analysis.
Wang et al., Wuhan, China. In Sci Rep, 2013
Transcriptional profiles and functional pathway analyses further demonstrated that 7 genes (FEN1, RFC5, EXO1, XRCC5, PARP1, POLR2F, and GTF2H3) that were relatively up-regulated in HL-60[R] cells and repressed in cells with ATRA-induced differentiation were related to mismatch repair in eukaryotes, DNA double-strand break repair, and nucleotide excision repair pathways.
Correct assembly of RNA polymerase II depends on the foot domain and is required for multiple steps of transcription in Saccharomyces cerevisiae.
Navarro et al., Jaén, Spain. In Mol Cell Biol, 2013
We demonstrate that the foot of RNA pol II is crucial for the assembly and stability of the complex, by ensuring the correct association of Rpb1 with Rpb6 and of the dimer Rpb4-Rpb7 (Rpb4/7).
The prefoldin bud27 mediates the assembly of the eukaryotic RNA polymerases in an rpb5-dependent manner.
Navarro et al., Jaén, Spain. In Plos Genet, 2012
Supporting this, our data demonstrate that the lack of Bud27 affects the correct assembly of Rpb5 and Rpb6 to the three RNA polymerases, suggesting that this process occurs in the cytoplasm and is a required step prior to nuclear import.
[Novel complexes of gene expression and their role in the appearance and evolution of the genus Homo].
Shpakovskiĭ et al., In Tsitologiia, 2012
The RNA polymerase I-III common subunit hRPB6 (POLR2F) and basal component of the exon-exon junction complex Y14 (RBM8A) have been found among the protein partners of the isoforms hRPB 11bbeta and hRPB 11cbeta together with a number of proteins involved in the biogenesis of microRNAs, including a novel, not previously described variant of the microRNA processing nuclease DROSHA, which indicates the existence of a special coordination between processes of transcription and RNA interference in the nuclei of human cells.
Transcriptomic signature of cell lines isolated from canine mammary adenocarcinoma metastases to lungs.
Motyl et al., Warsaw, Poland. In J Appl Genet, 2009
These differently expressed genes are involved mainly in signal transduction, cell structure and motility, nucleic acid metabolism, developmental processing, and apoptosis (GHSR, RASSF1, ARF1GAP, WDR74, SMOC2, SFRP4, DIAPH1, FSCN1, ALX4, SNX15, PLD2, WNT7B, POU6F2, NKG7, and POLR2F).
POLR2F, ATP6V0A1 and PRNP expression in colorectal cancer: new molecules with prognostic significance?
Kalofonos et al., Pátrai, Greece. In Anticancer Res, 2008
POLR2F and PRNP exhibited elevated levels in carcinomas compared to normal tissue samples suggesting a possible role for these molecules in colorectal cancer.
Diversification of function by different isoforms of conventionally shared RNA polymerase subunits.
Gull et al., Brussels, Belgium. In Mol Biol Cell, 2007
At the core of each complex is a set of 12 highly conserved subunits of which five--RPB5, RPB6, RPB8, RPB10, and RPB12--are thought to be common to all three polymerase classes.
Purification of an eight subunit RNA polymerase I complex in Trypanosoma brucei.
Günzl et al., Farmington, United States. In Mol Biochem Parasitol, 2006
Thus far, data mining of trypanosomatid genomes have revealed 13 potential RNA pol I subunits which include two paralogous sets of RPB5, RPB6, and RPB10.
Characterization of RNA polymerase II subunits of Trypanosoma brucei.
Vanhamme et al., Brussels, Belgium. In Mol Biochem Parasitol, 2006
Nine subunits homologous to the other eukaryotic RNA Pol II, namely RPB1, RPB2, RPB3, RPB4, RPB5, RPB6, RPB7, RPB8 and RPB11, were identified in the purified complex.
An in silico analysis of trypanosomatid RNA polymerases: insights into their unusual transcription.
Gull et al., Oxford, United Kingdom. In Biochem Soc Trans, 2005
Out of the five shared subunits, both RPB5 and RPB6 have two isoforms in the three trypanosomes.
Reference genes identified in SH-SY5Y cells using custom-made gene arrays with validation by quantitative polymerase chain reaction.
Day et al., Zürich, Switzerland. In Anal Biochem, 2005
By doing so, we were able to identify GAPD, M-RIP, and POLR2F as stable and usable reference genes irrespective of differentiation status and Abeta(42) treatment.
The A14-A43 heterodimer subunit in yeast RNA pol I and their relationship to Rpb4-Rpb7 pol II subunits.
Carles et al., Gif-sur-Yvette, France. In Proc Natl Acad Sci U S A, 2002
In this paper, using biochemical and genetic approaches, we demonstrate that the A43 polypeptide forms a stable heterodimer with the A14 pol I subunit and interacts with the common ABC23 subunit, the yeast counterpart of the omega subunit of bacterial RNA polymerase.
Partners of Rpb8p, a small subunit shared by yeast RNA polymerases I, II and III.
Thuriaux et al., Gif-sur-Yvette, France. In Mol Cell Biol, 2001
Human Rpb6p is phosphorylated at its N-terminal Ser2, but an alanyl replacement at this position still complements an rpb6-Delta null allele.
Solution structure of the hRPABC14.4 subunit of human RNA polymerases.
Wagner et al., Boston, United States. In Nat Struct Biol, 1999
Solution structure of the hRPABC14.4 subunit of human RNA polymerases.(RPABC14.4 ?)
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