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CD180 molecule

RP105, CD180, LY64
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TLR4, MD-1, MD-2, CAN, V1a
Papers on RP105
The Structural Basis for Lipid and Endotoxin Binding in RP105-MD-1, and Consequences for Regulation of Host Lipopolysaccharide Sensitivity.
Bond et al., Cambridge, United Kingdom. In Structure, Feb 2016
MD-1 is a member of the MD-2-related lipid-recognition (ML) family, and associates with RP105, a cell-surface protein that resembles Toll-like receptor 4 (TLR4).
RP105 protects against myocardial ischemia-reperfusion injury via suppressing TLR4 signaling pathways in rat model.
Li et al., Yichang, China. In Exp Mol Pathol, Jan 2016
Radioprotective 105kDa protein (RP105) is a regulator of Toll-like receptor 4 (TLR4), an inflammatory factor whose functions have been reported in myocardial I/R injury.
CD180 overexpression in follicular lymphoma is restricted to the lymph node compartment.
Baseggio et al., Saint-Pierre-des-Corps, France. In Cytometry B Clin Cytom, Nov 2015
CD180 is an orphan member of the TLR family that modulates the signaling of several TLRs, but only limited studies have evaluated its expression by flow cytometry (FCM) in LPD.
RP105 Engages Phosphatidylinositol 3-Kinase p110δ To Facilitate the Trafficking and Secretion of Cytokines in Macrophages during Mycobacterial Infection.
Blumenthal et al., Brisbane, Australia. In J Immunol, Nov 2015
We demonstrate that the p110δ catalytic subunit of PI3K acts as a downstream effector of the TLR family member RP105 (CD180) in promoting mycobacteria-induced cytokine production by macrophages.
CD180 expression in B-cell lymphomas: A multicenter GEIL study.
GEIL (Groupe d'Etude Immunologique des Leucémies) et al., Strasbourg, France. In Cytometry B Clin Cytom, Oct 2015
UNASSIGNED: CD180, a related member of the Toll-like receptor family, is lost or underexpressed at the plasma membrane in circulating cells of various B-cell lymphomas except marginal zone lymphomas (MZL).
Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cells.
Hou et al., Nanjing, China. In Cell Mol Immunol, Sep 2015
Previous studies have shown that CD180-negative B cells, which are dramatically increased in SLE patients, are responsible for the production of auto-antibodies.
RP105 Protects Against Apoptosis in Ischemia/Reperfusion-Induced Myocardial Damage in Rats by Suppressing TLR4-Mediated Signaling Pathways.
Yang et al., Yichang, China. In Cell Physiol Biochem, 2014
In contrast, the radioprotective 105 kDa protein (RP105) is a specific negative regulator of TLR4 signaling pathways.
Comparative Geometrical Analysis of Leucine-Rich Repeat Structures in the Nod-Like and Toll-Like Receptors in Vertebrate Innate Immunity.
Kretsinger et al., Sapporo, Japan. In Biomolecules, 2014
In contrast, the TLR LRRs adopt either a left-handed helix or are nearly flat; RP105 and CD14 also adopt a left-handed helix.
Human CD180 Transmits Signals via the PIM-1L Kinase.
Schweighoffer et al., Basel, Switzerland. In Plos One, 2014
The CD180/MD1 molecular complex is an unusual member of the TLR family, since it lacks the components that are normally required for signal transduction by other TLRs.
Activation and regulation of the pattern recognition receptors in obesity-induced adipose tissue inflammation and insulin resistance.
Takatsu et al., Toyama, Japan. In Nutrients, 2013
Here, we discuss how various pattern recognition receptors in the immune system underlie the etiology of obesity-associated inflammation and insulin resistance, with a particular focus on the TLR (Toll-like receptor) family protein Radioprotective 105 (RP105)/myeloid differentiation protein-1 (MD-1).
[Negative regulation of Toll-like receptor signalling].
Choroszyńska et al., Lublin, Poland. In Postepy Hig Med Dosw (online), 2012
They include soluble receptors (sTLR), transmembrane proteins (ST2, SIGIRR, RP105, TRAIL-R) and intracellular inhibitors (SOCS-1, SOCS-3, sMyD88, TOLLIP, IRAK-M, SARM, A20, β-arrestin, CYLD, SHP).
The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells.
Takatsu et al., Toyama, Japan. In Int Immunol, 2012
Data show that both RP105/MD-1 and TLR4/MD-2 are expressed in marginal zone (MZ) B cells.
The anti-inflammatory actions of IL-4 in human monocytes are not mediated by IL-10, RP105 or the kinase activity of RIPK2.
Hart et al., Perth, Australia. In Cytokine, 2012
IL-4 failed to up-regulate expression of RP105 at the cell surface. In conclusion, the anti-inflammatory actions of IL-4 occur independently of IL-10, RP105, and the kinase activity of RIPK2
The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation.
Nagai et al., Toyama, Japan. In Diabetes, 2012
The RP105/MD-1 complex is a major mediator of adipose tissue inflammation independent of TLR4 signaling and may represent a novel therapeutic target for obesity-associated metabolic disorders.
Cutting edge: regulation of TLR4-driven B cell proliferation by RP105 is not B cell autonomous.
Karp et al., Cincinnati, United States. In J Immunol, 2012
Modulation of B cell proliferation by RP105 is not a function of B cell-intrinsic expression of RP105.
[BCMA and autoantibody-producing RP105 B cells; possible new targets of B cell therapy in systemic lupus erythematosus].
Tada et al., Saga, Japan. In Nihon Rinsho Meneki Gakkai Kaishi, 2011
RP105 (CD180) is one of the toll-like receptor associated molecules.
RP105-negative B cells in systemic lupus erythematosus.
Tada et al., Saga, Japan. In Clin Dev Immunol, 2011
RP105 (CD180), the toll-like receptor- (TLR-) associated molecule, is expressed on normal B cells.
Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family.
Shimizu et al., Tokyo, Japan. In J Mol Biol, 2011
Both mouse and human RP105/MD-1 exhibit dimerization of the 1:1 RP105/MD-1 complex, demonstrating a novel organization.
Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105.
Karp et al., Cincinnati, United States. In Nat Immunol, 2005
RP105 regulated TLR4 signaling in dendritic cells
Lyn tyrosine kinase: accentuating the positive and the negative.
Tarlinton et al., Melbourne, Australia. In Immunity, 2005
Somewhat paradoxically, it is also a key mediator in several pathways of B cell activation, such as CD19 and CD180.
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