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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Programmed cell death 2

Rp-8, PDCD2
This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: PKG, V1a, ACID, HAD, CAN
Papers using Rp-8 antibodies
Quantification of Lipophilicity of 1,2,4-Triazoles Using Micellar Chromatography
Pachuta-Stec Anna et al., In Chromatographia, 2004
... and RP-8 F254s (10 × 10 cm) were purchased from Merck.
Papers on Rp-8
Citron Rho-interacting kinase mediates arsenite-induced decrease in endothelial nitric oxide synthase activity by increasing phosphorylation at threonine 497: Mechanism underlying arsenite-induced vascular dysfunction.
Jo et al., Seoul, South Korea. In Free Radic Biol Med, Jan 2016
Although treatment with H-89, a known protein kinase A (PKA) inhibitor, inhibited arsenite-stimulated eNOS-Thr(497) phosphorylation, no inhibition was found in cells treated with other PKA inhibitors, including Rp-8-Br-cAMPS or PKI.
The vasodilator papaverine stimulates L-type Ca(2+) current in rat tail artery myocytes via a PKA-dependent mechanism.
Saponara et al., Siena, Italy. In Vascul Pharmacol, Jan 2016
The PKA inhibitor H89, but not the PKG inhibitor Rp-8-Br-cGMPS, antagonised papaverine- as well as IBMX- (another phosphodiesterase inhibitor) induced IBa(L) stimulation.
Calcitonin gene-related peptide inhibits autophagic-lysosomal proteolysis through cAMP/PKA signaling in rat skeletal muscles.
Navegantes et al., São Paulo, Brazil. In Int J Biochem Cell Biol, Jan 2016
In denervated muscles and starved C2C12 cells, Rp-8-Br-cAMPs or PKI, two PKA inhibitors, completely abolished the inhibitory effect of CGRP on Foxo1, 3 and 4 and LC3 lipidation.
PDCD2 and NCoR1 as putative tumor suppressors in gastric gastrointestinal stromal tumors.
Zhao et al., Shenyang, China. In Cell Oncol (dordr), Dec 2015
Previously, PDCD2 (programmed cell death protein 2) has been identified as a putative tumor suppressor in gastric cancer.
Simultaneous determination of imigliptin and its three metabolites in human plasma and urine by liquid chromatography coupled to tandem mass spectrometry.
Hu et al., Beijing, China. In J Chromatogr B Analyt Technol Biomed Life Sci, Nov 2015
The extracts were injected onto a SymmetryShield RP8 column with a gradient elution of acetonitrile and water containing 5mM ammonium acetate (pH 7).
Inhibitory Effects of Cytosolic Ca(2+) Concentration by Ginsenoside Ro Are Dependent on Phosphorylation of IP3RI and Dephosphorylation of ERK in Human Platelets.
Park et al., South Korea. In Evid Based Complement Alternat Med, 2014
G-Ro inhibited strongly thrombin-elevated [Ca(2+)] i , which was strongly increased by A-kinase inhibitor Rp-8-Br-cAMPS compared to G-kinase inhibitor Rp-8-Br-cGMPS.
Programmed cell death 2 functions as a tumor suppressor in osteosarcoma.
Du et al., Jinan, China. In Int J Clin Exp Pathol, 2014
OBJECTIVES: To investigate the role of programmed cell death 2 (PDCD2) in osteosarcoma (OS), along with correlations between PDCD2 and CD4(+)/CD8(+).
Scutellarin Reduces Endothelium Dysfunction through the PKG-I Pathway.
Yang et al., Kunming, China. In Evid Based Complement Alternat Med, 2014
In rat CIR model, wire myography demonstrated that SCU (45 and 90 mg/kg, i.v.) significantly reduced ischemic size by partially restoring the endothelium dependent vasodilation of BA; PKG inhibitor Rp-8-Br-cGMPS (50 μg/kg, i.v.) reversed this protection of SCU in CIR rats.
Scutellarin's Cardiovascular Endothelium Protective Mechanism: Important Role of PKG-Iα.
Yang et al., Kunming, China. In Plos One, 2014
PKG inhibitor Rp-8-Br-cGMP (50 μg/kg, iv) could ameliorate the protective effects of SCU.
PKC and AKT Modulate cGMP/PKG Signaling Pathway on Platelet Aggregation in Experimental Sepsis.
Marcondes et al., Campinas, Brazil. In Plos One, 2014
The guanylyl cyclase inhibitor ODQ (25 μM) and the PKG inhibitor Rp-8-Br-PET-cGMPS (25 μM) fully reversed the inhibitory effect of LPS on platelet aggregation.
PDCD2 is essential for inner cell mass development and embryonic stem cell maintenance.
Schimenti et al., Ithaca, United States. In Dev Biol, 2010
Pdcd2(-/-) embryos underwent implantation but did not undergo further development. Inner cell masses from Pdcd2(-/-) blastocysts failed to outgrow in vitro.
PDCD2, a protein whose expression is repressed by BCL6, induces apoptosis in human cells by activation of the caspase cascade.
Baron et al., Chicago, United States. In Blood Cells Mol Dis, 2010
Transfection of a construct expressing PDCD2 induces apoptosis in human cell lines through activation of the caspase cascade.
Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease.
Hattori et al., Tokyo, Japan. In Febs Lett, 2009
parkin interacts with programmed cell death-2 isoform 1 (PDCD2-1)
Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas.
Baron et al., Chicago, United States. In Proc Natl Acad Sci U S A, 2007
repression of PDCD2 by BCL6 is likely important in the pathogenesis of certain human lymphomas
Cloning of cDNAs with PDCD2(C) domain and their expressions during apoptosis of HEK293T cells.
Yan et al., Hangzhou, China. In Mol Cell Biochem, 2005
To study the role of PDCD2_C domain in apoptosis, the cDNAs of two isoforms of PDCD2 and MGC13096 were cloned. PDCD2 (NM_002598) was over expressed when endothelial cells treated with leukotriene D4 or natural killer cells were activated by IL-2.
Modulation of synaptic function by cGMP and cGMP-gated cation channels.
Han et al., New Haven, United States. In Neurochem Int, 2004
Rp-8-Br-cGMPS has shown the opposite effects, namely as an agonist of the rod CNG channel and an inhibitor of PKG.
[Genomics of type I diabetes mellitus and its late complications].
Nosikov, Moscow, Russia. In Mol Biol (mosk), 2004
With these families, linkage to T1DM was demonstrated for CTLA4 (IDDM12, 2q32.1-q33), which codes for a T-cell surface antigen, and PDCD2 (IDDM8, 6q25-q27), which is homologous to the mouse programmed cell death activator gene.
Systematic toxicological analysis by high-performance liquid chromatography with diode array detection (HPLC-DAD).
Erxleben et al., Berlin, Germany. In Clin Chem Lab Med, 2003
The efficiency of the method is demonstrated for an example of a routine procedure using liquid-liquid extraction with CH 2 Cl 2 and protein precipitation for sample preparation, a system of three isocratic mobile phases with different acetonitrile/phosphate buffer ratios and RP8 columns for chromatography and a database of 2682 UV spectra and relative retention times for substance identification.
Progesterone as a regulator of granulosa cell viability.
Peluso, Farmington, United States. In J Steroid Biochem Mol Biol, 2003
Additional studies demonstrate that a protein kinase G (PKG) activator, 8-br-cGMP, mimics and PKG antagonists, Rp-8-pcCPT-GMP and KT5823, attenuate P4's action.
Cyclic nucleotide analogs as biochemical tools and prospective drugs.
Jastorff et al., Bremen, Germany. In Pharmacol Ther, 2000
For instance, Rp-8-bromo-adenosine 3',5'-cyclic monophosphorothioate is employed against diseases of the immune system.
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