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RAR-related orphan receptor A

RORalpha, RORA
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Staggerer, ACID, CLOCK, CAN, V1a
Papers on RORalpha
Expression Profiles of Cytokine mRNAs in the Pleural Fluid Reveal Differences Among Tuberculosis, Malignancies, and Pneumonia-Exudative Pleural Effusions.
da Fonseca et al., Ribeirão Preto, Brazil. In Lung, Dec 2015
RESULTS: The majority of cytokine-related genes expressed in pleural fluid of TB patients were similar in non-TB patients, except for RORA and RORC genes, which showed a statistically higher level in TB.
Circadian clock-related genetic risk scores and risk of placental abruption.
Williams et al., Seattle, United States. In Placenta, Dec 2015
We examined 119 SNPs in 13 candidate genes known to control circadian rhythms (e.g., CRY2, ARNTL, and RORA).
IL-25 and CD4(+) TH2 cells enhance type 2 innate lymphoid cell-derived IL-13 production, which promotes IgE-mediated experimental food allergy.
Wang et al., Bangkok, Thailand. In J Allergy Clin Immunol, Dec 2015
Reconstituting irradiated wild-type mice with Rora(-/-) or Il17rb(-/-) bone marrow resulted in a deficiency or dysfunction of the ILC2 compartment, respectively, and resistance to experimental food allergy.
[Circadian markers and genes in bipolar disorder].
Belliviera et al., Paris, France. In Encephale, Sep 2015
Several genetic association studies have also showed associations between multiple circadian genes and bipolar disorder, such as CLOCK, ARTNL1, GSK3β, PER3, NPAS2, NR1D1, TIMELESS, RORA, RORB, and CSNK1ε.
Mitochondrial E3 Ubiquitin Protein Ligase 1 Mediates Cigarette Smoke-Induced Endothelial Cell Death and Dysfunction.
Lee et al., Suwŏn, South Korea. In Am J Respir Cell Mol Biol, Aug 2015
Finally, we found that CSE-mediated MUL1 induction in HLMVECs is mediated by retinoic acid receptor-related orphan receptor alpha (RORA).
Identification of a spinal circuit for light touch and fine motor control.
Goulding et al., Los Angeles, United States. In Cell, Mar 2015
These neurons express the ROR alpha (RORα) nuclear orphan receptor and are selectively innervated by cutaneous low threshold mechanoreceptors (LTMs).
Identification of lung cancer oncogenes based on the mRNA expression and single nucleotide polymorphism profile data.
Chen et al., In Neoplasma, 2014
Besides, PIK3R1 (phosphoinositide-3-kinase, regulatory subunit 1), RORA (RAR-related orphan receptor A), MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3), PTPRM (protein tyrosine phosphatase, receptor type, M), and BMP6 (bone morphogenetic protein 6) were the hub genes in PPI network.
Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors.
Daley et al., Boston, United States. In Cell Stem Cell, 2013
HOXA9, ERG, and RORA conferred self-renewal and multilineage potential in vitro and maintained primitive CD34(+)CD38(-) cells.
The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression.
Jeker et al., San Francisco, United States. In Nat Immunol, 2013
In a viral infection model, miR-17∼92 restrained the expression of genes 'inappropriate' to the TFH cell subset, including the direct miR-17∼92 target Rora.
[The pathophysiological roles and regulatory mechanism of retinoic acid receptor-related orphan receptors].
He et al., Shanghai, China. In Sheng Li Ke Xue Jin Zhan, 2013
RORs subfamily consists of three members: RORalpha, RORbeta, and RORgamma.
Decoding asthma: translating genetic variation in IL33 and IL1RL1 into disease pathophysiology.
Nawijn et al., Groningen, Netherlands. In J Allergy Clin Immunol, 2013
The relevance of these cells for asthma is underscored by the identification of retinoic acid-related orphan receptor α(RORA), the gene encoding the transcription factor critical for their differentiation, as another asthma gene in genome-wide association studies.
Is retinoic acid-related orphan receptor-alpha (RORA) a target for gene-environment interactions contributing to autism?
Hu, Washington, D.C., United States. In Neurotoxicology, 2012
Based on our published studies, I propose that the demonstrated responsiveness of RORA to sex hormones makes it a prime target for disruption by endocrine disrupting compounds.
Clock gene variants in mood and anxiety disorders.
Partonen, Helsinki, Finland. In J Neural Transm, 2012
The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression.
Retinoic acid-related orphan receptor-α is induced in the setting of DNA damage and promotes pulmonary emphysema.
Morse et al., Boston, United States. In Am J Respir Crit Care Med, 2012
Rora expression was induced by cigarette smoke in mice and cell culture. Rora-deficient mice were protected from smoke induced airspace enlargement. DNA damage may contribute to pathogenesis of emphysema and Rora has a role in responses to genotoxicity.
RORα suppresses breast tumor invasion by inducing SEMA3F expression.
Xu et al., Lexington, United States. In Cancer Res, 2012
showed that transcription of SEMA3F is directly regulated by RORalpha
Expression of retinoic acid-related orphan receptor alpha and its responsive genes in human endometrium regulated by cholesterol sulfate.
Taketani et al., Tokyo, Japan. In J Steroid Biochem Mol Biol, 2012
retinoic acid-related orphan receptor alpha significantly activated the human NR1D1 promoter
Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα).
Burris et al., Jupiter, United States. In Plos One, 2011
Citrate synthase (CS) is a direct RORalpha target gene and one mechanism by which RORalpha regulates lipid metabolism is via regulation of CS expression.
Regulation of p53 stability and apoptosis by a ROR agonist.
Burris et al., Jupiter, United States. In Plos One, 2011
We demonstrate that treatment of cancer cells with a newly described synthetic ROR agonist, SR1078, leads to p53 stabilization and induction of apoptosis.
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
Kooner et al., London, United Kingdom. In Nat Genet, 2011
We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827).
IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors.
Takayanagi et al., Tokyo, Japan. In Nature, 2010
IL-6 and transforming growth factor-beta (TGF-beta) induce T(H)17 development, in which the orphan nuclear receptors, RORgammat and RORalpha, have an indispensable role.
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