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Retinal outer segment membrane protein 1

Rom, rom-1
This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor, retinal degeneration slow (RDS). It is essential for disk morphogenesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Peripherin, ROD, CAN, Rhodopsin, ACID
Papers on Rom
PRPH2/RDS and ROM-1: historical context, current views and future considerations.
Naash et al., Oklahoma City, United States. In Prog Retin Eye Res, Feb 2016
UNASSIGNED: Peripherin2 (PRPH2), also known as RDS (retinal degeneration slow) is a photoreceptor specific glycoprotein which is essential for normal photoreceptor health and vision.
Varying the GARP2-to-RDS Ratio Leads to Defects in Rim Formation and Rod and Cone Function.
Naash et al., Oklahoma City, United States. In Invest Ophthalmol Vis Sci, Jan 2016
Overexpression of GARP2 led to abnormalities in disc stacking in GARP2-Tg/rds+/+ and the accumulation of abnormal vesicular structures in GARP2-Tg/rds+/- OS, as well as alterations in RDS-ROM-1 complex formation.
Decellularized retinal matrix: Natural platforms for human retinal progenitor cell culture.
Carrier et al., Boston, United States. In Acta Biomater, Dec 2015
Rhodopsin, ROM1, NRL and CRX gene expression on the decell-retina films indicated photoreceptor development from RPCs.
Retinal Degeneration Slow (RDS) Glycosylation Plays a Role in Cone Function and in the Regulation of RDS·ROM-1 Protein Complex Formation.
Naash et al., Oklahoma City, United States. In J Biol Chem, Dec 2015
Normal levels of RDS and the unglycosylated RDS binding partner rod outer segment membrane protein 1 (ROM-1) were found in N229S retinas.
The glycoprotein precursor gene of Junin virus determines the virulence of the Romero strain and the attenuation of the Candid #1 strain in a representative animal model of Argentine hemorrhagic fever.
Paessler et al., Galveston, United States. In J Virol, Jun 2015
Here, we utilized a reverse genetics approach to generate recombinant JUNV (rJUNV) strains encoding different gene combinations of the pathogenic Romero (Rom) and attenuated Can strains of JUNV.
SNAREs Interact with Retinal Degeneration Slow and Rod Outer Segment Membrane Protein-1 during Conventional and Unconventional Outer Segment Targeting.
Naash et al., Oklahoma City, United States. In Plos One, 2014
RDS and its homolog ROM-1 (rod outer segment protein 1) are synthesized in the inner segment and then trafficked into the outer segment where they function in tetramers and covalently linked larger complexes.
History of the preanalytical phase: a personal view.
Guder, München, Germany. In Biochem Med (zagreb), 2013
This includes the definitions of influence and interference factors as well as the first publications in book, internet, CD-Rom and recent App form over the past 40 years.
Structural and functional relationships between photoreceptor tetraspanins and other superfamily members.
Naash et al., Oklahoma City, United States. In Cell Mol Life Sci, 2012
The two primary photoreceptor-specific tetraspanins are retinal degeneration slow (RDS) and rod outer segment membrane protein-1 (ROM-1).
Overexpression of ROM-1 in the cone-dominant retina.
Naash et al., Oklahoma City, United States. In Adv Exp Med Biol, 2011
ROM1 overexpression leads to negative effects on cone outer segments ultrastructure and function.
ABCA4 and ROM1: implications for modification of the PRPH2-associated macular dystrophy phenotype.
Neidhardt et al., Freiburg, Germany. In Invest Ophthalmol Vis Sci, 2010
Families showing a variable macular dystrophy phenotype caused by mutations in PRPH2 should be tested for additional mutations in ABCA4 and ROM1, as they may alter the progression of the PRPH2 phenotype.
A monogenic dominant mutation in Rom1 generated by N-ethyl-N-nitrosourea mutagenesis causes retinal degeneration in mice.
Wakana et al., Sendai, Japan. In Mol Vis, 2009
The results suggested that Trp182Arg mutant Rom1 causes a decrease in the levels of wild-type Prph2 and Rom1.
The role of cholesterol in rod outer segment membranes.
Boesze-Battaglia et al., United States. In Prog Lipid Res, 2005
The availability of the disk protein, rom-1 may be sensitive to membrane cholesterol.
Role of subunit assembly in autosomal dominant retinitis pigmentosa linked to mutations in peripherin 2.
Loewen et al., Vancouver, Canada. In Novartis Found Symp, 2003
Peripherin 2 and ROM1 assemble as a mixture of core noncovalent homomeric and heteromeric tetramers that further link together through disulfide bonds to form higher order oligomers.
Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy.
Thrasher et al., London, United Kingdom. In Nat Genet, 2000
The gene Prph2 encodes a photoreceptor-specific membrane glycoprotein, peripherin-2 (also known as peripherin/rds), which is inserted into the rims of photoreceptor outer segment discs in a complex with rom-1 (ref.
Rom-1 is required for rod photoreceptor viability and the regulation of disk morphogenesis.
McInnes et al., Toronto, Canada. In Nat Genet, 2000
We conclude that Rom-1 is required for the regulation of disk morphogenesis and the viability of mammalian rod photoreceptors, and that mutations in human ROM1 may cause recessive photoreceptor degeneration.
Bent helix formation between RNA hairpins with complementary loops.
Crothers et al., New Haven, United States. In Science, 1995
The bend is further enhanced by the binding of Rom, a ColE1 encoded protein that regulates replication.
Digenic retinitis pigmentosa due to mutations at the unlinked peripherin/RDS and ROM1 loci.
Dryja et al., Boston, United States. In Science, 1994
Three families were identified with mutations in the unlinked photoreceptor-specific genes ROM1 and peripherin/RDS, in which only double heterozygotes develop retinitis pigmentosa (RP).
Control of ColE1 plasmid replication: enhancement of binding of RNA I to the primer transcript by the Rom protein.
Som et al., In Cell, 1984
The Rom protein, a plasmid-specified 63 amino acid protein, enhances the inhibitory effect of RNA I on primer formation by enhancing the binding of RNA I to RNA II.
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