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Roundabout homolog 2

This gene belongs to the ROBO family, part of the immunoglobulin superfamily proteins that are highly conserved from fly to human. The encoded protein is a receptor for SLIT2, molecules known to function in axon guidance and cell migration. Defects in this gene are the cause of vesicoureteral reflux type 2. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Robo1, Slit2, Midline, Robo3, CAN
Papers on Robo2
BmRobo2/3 is required for axon guidance in the silkworm Bombyx mori.
Liu et al., Tai'an, China. In Gene, Mar 2016
In this study, we cloned robo2/3 from B. mori (Bmrobo2/3), a homologue of robo2/3 in Tribolium castaneum.
Rare variants in tenascin genes in a cohort of children with primary vesicoureteric reflux.
Gbadegesin et al., Durham, United States. In Pediatr Nephrol, Feb 2016
METHODS: To define the role of rare variants in tenascin genes in the etiology of PVUR, we screened a cohort of patients with familial PVUR (FPVUR) and non-familial PVUR (NFPVUR) for rare missense variants inTNXB and the tenascin C gene (TNC) after excluding mutations in ROBO2 and SOX17.
A non-signaling role of Robo2 in tendons is essential for Slit processing and muscle patterning.
Volk et al., Israel. In Development, Nov 2015
Here, we show that the Slit receptor Roundabout 2 (Robo2) plays a non-cell-autonomous role in directing muscles to their corresponding tendons.
New insights into implication of the SLIT/ROBO pathway in the prehierarchical follicle development of hen ovary.
Xu et al., Changchun, China. In Poult Sci, Sep 2015
The aims of the present study were to examine the spatial and temporal expression of the SLIT ligand genes (SLIT1, SLIT2, and SLIT3) and their receptor ROBO1, ROBO2, ROBO3, and ROBO4 genes in various-sized prehierarchical follicles during hen ovary development and the effects of activin A and inhibin A on the expression of these genes in the cultured hen follicles.
Genetics of Opisthorchis viverrini-related cholangiocarcinoma.
Teh et al., Khon Kaen, Thailand. In Curr Opin Gastroenterol, May 2015
MLL3 (13%) and IDH1/2 (2.8%)], WNT signaling [RNF43 (9.3%) and PEG3 (5.6%)] and KRAS/G protein signaling [GNAS (9.3%) and ROBO2 (9.3%)].
Whole genomes redefine the mutational landscape of pancreatic cancer.
Grimmond et al., Brisbane, Australia. In Nature, Mar 2015
Chromosomal rearrangements leading to gene disruption were prevalent, affecting genes known to be important in pancreatic cancer (TP53, SMAD4, CDKN2A, ARID1A and ROBO2) and new candidate drivers of pancreatic carcinogenesis (KDM6A and PREX2).
Whole-exome and targeted sequencing identify ROBO1 and ROBO2 mutations as progression-related drivers in myelodysplastic syndromes.
Li et al., Shanghai, China. In Nat Commun, 2014
Here we identify ROBO1 and ROBO2 as novel progression-related somatic mutations using whole-exome and targeted sequencing in 6 of 16 (37.5%)
Involvement of Slit-Robo signaling in the development of the posterior commissure and concomitant swimming behavior in Xenopus laevis.
Murakami et al., Japan. In Zoological Lett, 2014
RESULTS: Here, we report the developmentally regulated expression pattern of axon-guidance molecules Slit2 ligand and Robo2 receptor in Xenopus laevis and show that treatment of X. laevis larvae with a slit2- or robo2-morpholino resulted in abnormal swimming behavior.
Robo2--slit and Dcc--netrin1 coordinate neuron axonal pathfinding within the embryonic axon tracts.
Peng et al., Shanghai, China. In J Neurosci, 2012
Robo2-Slit and Dcc-Netrin1 coordinate the axonal projection choices of neurons developing in the forebrain.
3p interstitial deletion: novel case report and review.
Budişteanu et al., Bucureşti, Romania. In J Child Neurol, 2012
Genetic investigations revealed a del(3)(p12.3p14.1) of 12.5 Mb, including 31 ORFs, among which ROBO2, PDZRN3, MITF, and FOXP1 are known to act in neurodevelopment.
Exome sequencing of liver fluke-associated cholangiocarcinoma.
Teh et al., Singapore, Singapore. In Nat Genet, 2012
These included inactivating mutations in MLL3 (in 14.8% of cases), ROBO2 (9.3%), RNF43 (9.3%) and PEG3 (5.6%), and activating mutations in the GNAS oncogene (9.3%).
Overexpression of Robo2 causes defects in the recruitment of metanephric mesenchymal cells and ureteric bud branching morphogenesis.
Chen et al., Beijing, China. In Biochem Biophys Res Commun, 2012
this study demonstrates that overexpression of Robo2 by microinjection in embryonic kidneys is an effective approach to study the function of Robo2.
Motor axon exit from the mammalian spinal cord is controlled by the homeodomain protein Nkx2.9 via Robo-Slit signaling.
Kaprielian et al., United States. In Development, 2012
Nkx2.9 controls SACMN axon exit from the mammalian spinal cord by regulating Robo-Slit signaling
Slit/Robo-mediated axon guidance in Tribolium and Drosophila: divergent genetic programs build insect nervous systems.
Bashaw et al., Philadelphia, United States. In Dev Biol, 2012
Data show that Robo and Robo2 promote midline repulsion, while Robo2 and Robo3 specify the position of longitudinal axon pathways.
Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons.
Schier et al., Cambridge, United States. In Development, 2012
These results reveal that subtype-specific activity of Robo2 regulates subcircuit morphogenesis in the trigeminal sensory system.
Identifying gene regulatory networks in schizophrenia.
Xie et al., Irvine, United States. In Neuroimage, 2010
Several of these genes (RSRC1, ARHGAP18, ROBO1-ROBO2, GPC1, TNIK, and CTXN3-SLC12A2) have functions related to progenitor cell proliferation, migration, and differentiation, cytoskeleton reorganization, axonal connectivity, and development of forebrain structures.
Role of Slit proteins in the vertebrate brain.
Chédotal et al., Paris, France. In J Physiol Paris, 2002
Three distinct slit genes (slit1, slit2 and slit3) and three distinct robo genes (robo1, robo2 and rig-1) have been cloned in mammals.
astray, a zebrafish roundabout homolog required for retinal axon guidance.
Chien et al., Salt Lake City, United States. In Science, 2001
We identify astray as zebrafish robo2, a member of the Roundabout family of axon guidance receptors.
Selecting a longitudinal pathway: Robo receptors specify the lateral position of axons in the Drosophila CNS.
Dickson et al., Vienna, Austria. In Cell, 2001
In this long-range function, Slit signals through the receptors Robo2 and Robo3.
Short-range and long-range guidance by Slit and its Robo receptors: a combinatorial code of Robo receptors controls lateral position.
Goodman et al., Berkeley, United States. In Cell, 2001
Medial axons express only Robo, intermediate axons express Robo3 and Robo, while lateral axons express Robo2, Robo3, and Robo.
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