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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Family with sequence similarity 20, member C

This gene encodes a member of the family with sequence similarity 20 (FAM20) family of secreted proteins. A similar gene in mice encodes a protein that plays a role in dentin mineralization, and mutations in the human gene are associated with the autosomal recessive disorder Raine syndrome. [provided by RefSeq, Nov 2011] (from NCBI)
Top mentioned proteins: Ros, CAN, iNOS, V1a, ACID
Papers on RNS
Congenital myasthenic syndrome due to novel CHAT mutations in an ethnic kadazandusun family.
Goh et al., Kuala Lumpur, Malaysia. In Muscle Nerve, Feb 2016
A subsequent repetitive nerve stimulation (RNS) test showed marked decremental response in the abductor digiti minimi only after prolonged ulnar nerve stimulation.
Versatile antitumor potential of isoxanthohumol: enhancement of paclitaxel activity in vivo.
Maksimović-Ivanić et al., Belgrade, Serbia. In Pharmacol Res, Feb 2016
The described changes in cultures upon exposure to IXN could be connected with the suppression of reactive oxygen (ROS) and nitrogen species (RNS) induced by the drug.
Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications.
Arnér et al., Beijing, China. In Physiol Rev, Jan 2016
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from aerobic metabolism, as a result of accidental electron leakage as well as regulated enzymatic processes.
Cellular and subcellular oxidative stress parameters following severe spinal cord injury.
Rabchevsky et al., Lexington, United States. In Redox Biol, Jan 2016
Western blot analysis further showed that reactive oxygen/nitrogen species (ROS/RNS) mediated PC and 3-NT production were significantly higher in both fractions after SCI.
Sodium channel γENaC mediates IL-17 synergized high salt induced inflammatory stress in breast cancer cells.
Tiriveedhi et al., Saint Louis, United States. In Cell Immunol, Jan 2016
Combined treatment of high NaCl (0.15M) with sub-effective IL-17 (0.1nM) induced enhanced growth in breast cancer cells along with activation of reactive nitrogen and oxygen (RNS/ROS) species known to promote cancer.
Iron and Oxidative Stress in Parkinson's Disease: An Observational Study of Injury Biomarkers.
Fighera et al., Rio Grande, Brazil. In Plos One, Dec 2015
In addition to an accumulation of iron, there is also an increased production of reactive oxygen/nitrogen species (ROS/RNS) and inflammatory markers.
S-sulfhydration as a cellular redox regulation.
Wlodek et al., Kraków, Poland. In Biosci Rep, Dec 2015
UNASSIGNED: For many years reactive oxygen and nitrogen species (ROS and RNS) have been recognized as key messengers in the process of thiol-based redox regulation.
Mechanisms of nitric oxide crosstalk with reactive oxygen species scavenging enzymes during abiotic stress tolerance in plants.
Bhatla et al., Delhi, India. In Free Radic Res, Dec 2015
The exact molecular mechanism(s) by which exogenous and endogenously generated NO (or reactive nitrogen species; RNS) modulate the induction of various genes affecting redox homeostasis, are being extensively investigated currently by various research groups.
Redox Homeostasis and Mitochondrial Dynamics.
Koopman et al., Bordeaux, France. In Cell Metab, Sep 2015
Within living cells, mitochondria are considered relevant sources of reactive oxygen species (ROS) and are exposed to reactive nitrogen species (RNS).
Reactive oxygen and nitrogen species disturb Ca(2+) oscillations in insulin-secreting MIN6 β-cells.
Pedersen et al., Padova, Italy. In Islets, Aug 2015
Reactive oxygen/nitrogen species (ROS/RNS) are implicated in reduced β-cell function, and ROS/RNS target several Ca(2+) pumps and channels.
The Role Oxidative Stress in the Pathogenesis of Eye Diseases: Current Status and a Dual Role of Physical Activity.
Aboul-Enein et al., Al Jīzah, Egypt. In Mini Rev Med Chem, 2014
The most important oxidants are reactive oxygen species (ROS) and reactive nitrogen species (RNS) generated by various metabolic pathways, physical, chemical and biological factors, and pathological conditions.
[Redox modifications of cysteine residues in plant proteins].
Zagdańska et al., In Postepy Biochem, 2014
Reactive oxygen species (ROS) and reactive nitrogen species (RNS), considered as toxic by-products of aerobic metabolism, play a key role in intracellular signaling pathways.
Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing.
Rao et al., Stanford, United States. In Nat Biotechnol, 2014
The production of radical species, specifically reactive oxygen species (ROS) and reactive nitrogen species (RNS), has been proposed as an early unifying event linking the bioactivation of drugs to hepatotoxicity and as a more direct and mechanistic indicator of hepatotoxic potential.
Folding and self-assembly of the TatA translocation pore based on a charge zipper mechanism.
Ulrich et al., Karlsruhe, Germany. In Cell, 2013
Similar "charge zippers" are proposed for other membrane-associated proteins, e.g., the biofilm-inducing peptide TisB, the human antimicrobial peptide dermcidin, and the pestiviral E(RNS) protein.
Secreted kinase phosphorylates extracellular proteins that regulate biomineralization.
Dixon et al., San Diego, United States. In Science, 2012
Fam20C appears to be the Golgi casein kinase that phosphorylates secretory pathway proteins within S-x-E motifs; Fam20C phosphorylates caseins and several secreted proteins implicated in biomineralization; mutations in Fam20C cause an osteosclerotic bone dysplasia known as Raine syndrome
AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation.
Hamilton et al., Houston, United States. In Nat Med, 2012
AICAR thus prevents Ca(2+)-dependent increases in the amount of both reactive oxygen species (ROS) and reactive nitrogen species (RNS) that act to further increase resting Ca(2+) concentrations.
Osteosclerotic bone dysplasia in siblings with a Fam20C mutation.
Doray et al., Strasbourg, France. In Clin Genet, 2011
Osteosclerotic bone dysplasia in siblings with a Fam20C mutation
Mutations in FAM20C also identified in non-lethal osteosclerotic bone dysplasia.
Crosby et al., London, United Kingdom. In Clin Genet, 2009
Mutation of FAM20C does not always lead to the infantile lethality previously seen as a prerequisite for Raine syndrome diagnosis.
Mutations in FAM20C are associated with lethal osteosclerotic bone dysplasia (Raine syndrome), highlighting a crucial molecule in bone development.
Crosby et al., London, United Kingdom. In Am J Hum Genet, 2007
This study defines the causative role of FAM20C in this lethal osteosclerotic disorder and its crucial role in normal bone development.
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