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Tripartite motif containing 69

RNF36, ring finger protein 36
This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PI3K, Rel, PML, neuroligin-1, GluR3
Papers on RNF36
Genetic alterations in oral squamous cell carcinoma progression detected by combining array-based comparative genomic hybridization and multiplex ligation-dependent probe amplification.
Cha et al., Pusan, South Korea. In Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2011
In the dysplasia, amplification (100%, 7/7) was detected in RNF36 and deletion in CKAP2L and TCF8.
Modulation of NB4 promyelocytic leukemic cell machinery by Anaplasma phagocytophilum.
Fikrig et al., New Haven, United States. In Genomics, 2005
However, the expression of Toll-like receptors, MYD88, RNF36, IRF3, and TBK1 and inhibitors of the NF-kappaB gene was not altered.
Forced expression of RNF36 induces cell apoptosis.
Li et al., Taipei, Taiwan. In Exp Cell Res, 2003
RNF36 (ring finger protein 36; alias Trif), a member of the RING zinc finger protein family, is expressed in germ cells at round spermatid stages during spermatogenesis.
A novel member of the RBCC family, Trif, expressed specifically in the spermatids of mouse testis.
Li et al., Taipei, Taiwan. In Mech Dev, 2001
Gene and protein analysis of the mouse counterpart.
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