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Ribonuclease L

RNase L, ribonuclease L, 2-5A-dependent RNase
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, PKR, HAD, ACID, MEN
Papers on RNase L
Key genes involved in the immune response are generally not associated with intraprostatic inflammation in men without a prostate cancer diagnosis: Results from the prostate cancer prevention trial.
Platz et al., Kocaeli, Turkey. In Prostate, Feb 2016
We analyzed inflammation data from the review of H&E-stained prostate tissue sections from biopsies performed per protocol at the end of the trial irrespective of clinical indication, and data for 16 SNPs in key genes involved in the immune response (IL1β, IL2, IL4, IL6, IL8, IL10, IL12(p40), IFNG, MSR1, RNASEL, TLR4, TNFA; 7 tagSNPs in IL10).
Crystal structure of the mouse hepatitis virus ns2 phosphodiesterase domain that antagonizes RNase L activation.
Zhao et al., United States. In J Gen Virol, Feb 2016
During the interferon antiviral response, ns2 cleaves 2',5'-oligoadenylate (2-5A), a key mediator of RNase L activation, thereby subverting the activation of RNase L and evading host innate immunity.
Activation of RNase L by murine coronavirus in myeloid cells is dependent on basal Oas gene expression and independent of virus-induced interferon.
Weiss et al., Philadelphia, United States. In J Virol, Feb 2016
UNASSIGNED: The oligoadenylate synthetase-ribonuclease L (OAS-RNase L) pathway is a potent interferon (IFN) induced antiviral activity.
Human RNase L tunes gene expression by selectively destabilizing the microRNA-regulated transcriptome.
Korennykh et al., Princeton, United States. In Proc Natl Acad Sci U S A, Jan 2016
Double-stranded RNA (dsRNA) activates the innate immune system of mammalian cells and triggers intracellular RNA decay by the pseudokinase and endoribonuclease RNase L. RNase L protects from pathogens and regulates cell growth and differentiation by destabilizing largely unknown mammalian RNA targets.
Links between recognition and degradation of cytoplasmic viral RNA in innate immune response.
Daito et al., Sapporo, Japan. In Rev Med Virol, Jan 2016
RNase L is an ISG with endonuclease activity that degrades viral RNA, producing small RNA that activates RIG-I, resulting in the amplification of type I IFN production.
Inhibition of the OAS/RNase L pathway by viruses.
Michiels et al., Brussels, Belgium. In Curr Opin Virol, Dec 2015
The OAS/RNase L system was one of the first characterized interferon effector pathways.
Xenotropic Murine Leukemia Virus-Related Virus and RNase L R462Q Variants in Iranian Patients With Sporadic Prostate Cancer.
Mokhtari Azad et al., Tehrān, Iran. In Iran Red Crescent Med J, Dec 2015
Furthermore, some genetic and epidemiological studies have highlighted a role for RNase L polymorphisms, particularly R462Q, in the progression of prostate cancer.
Killing of cancer cells through the use of eukaryotic expression vectors harbouring genes encoding nucleases and ribonuclease inhibitor.
Glinka, Moscow, Russia. In Tumour Biol, May 2015
This review is focused on vectors bearing genes for nucleases such as deoxyribonucleases (caspase-activated DNase, deoxyribonuclease I-like 3, endonuclease G) and ribonucleases (human polynucleotide phosphorylase, ribonuclease L, α-sarcin, barnase), as well as vectors harbouring gene encoding ribonuclease inhibitor.
Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases.
Kim et al., Seoul, South Korea. In Exp Mol Med, 2014
One of the key antiviral factors induced by IFNs, 2'-5' oligoadenylate synthase (OAS), is a well-known molecule that regulates the early phase of viral infection by degrading viral RNA in combination with RNase L, resulting in the inhibition of viral replication.
[Ribonucleases as antiviral agents].
Shakh Makhmud et al., In Mol Biol (mosk), 2014
The review observes the most known RNases which possess established antiviral effects, actually intracellular RNases (RNase L, MCPIPI protein, eosinophylic RNases) as well as exogenously applied ones (RNase A, BS-RNase, onconase, binase, synthetic RNases).
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids.
Hopfner et al., Bonn, Germany. In Nat Rev Immunol, 2014
2'-5'-linked oligoadenylates limit viral propagation through the activation of the enzyme RNase L, which degrades host and viral RNA, and 2'-5'-linked cGAMP activates downstream signalling pathways to induce de novo antiviral gene expression.
Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response.
Korennykh et al., Princeton, United States. In Science, 2014
One of the hallmark mechanisms activated by type I interferons (IFNs) in human tissues involves cleavage of intracellular RNA by the kinase homology endoribonuclease RNase L. We report 2.8 and 2.1 angstrom crystal structures of human RNase L in complexes with synthetic and natural ligands and a fragment of an RNA substrate.
Predictive value in the analysis of RNASEL genotypes in relation to prostate cancer.
Cozar et al., Granada, Spain. In Prostate Cancer Prostatic Dis, 2012
genotypes associated with the worst prognoses in prostate cancer are G/G in D541E, A/A in R462Q and A/G in I97L.
[RNASEL study of genetics of prostate cancer and its relation to clinical staging].
Cozar et al., Granada, Spain. In Actas Urol Esp, 2012
Statistically significant differences were found between controls and patients in some of the genotyped regions of the RNASEL gene
Genetic variants in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes are prognostic markers of prostate cancer-specific mortality.
Stanford et al., Seattle, United States. In Cancer Epidemiol Biomarkers Prev, 2011
Five SNPs were validated as being significantly associated with prostate cancer mortality, one each in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes.
The effect of TP53 codon 72 and RNASEL codon 462 polymorphisms on the development of cervical cancer in Argentine women.
Golijow et al., La Plata, Argentina. In Cancer Genet, 2011
Codon 462 polymorphisms within the RNASEL gene are not associated with an increased risk of cervical cancer.
Lopinavir up-regulates expression of the antiviral protein ribonuclease L in human papillomavirus-positive cervical carcinoma cells.
Hampson et al., Manchester, United Kingdom. In Antivir Ther, 2010
Ribonuclease L (RNASEL) protein was shown to be up-regulated in lopinavir-treated SiHa cells, which was confirmed by PCR and western blot. Targeted silencing of RNASEL reduced the sensitivity of SiHa cells to lopinavir.
RIG-I detects viral genomic RNA during negative-strand RNA virus infection.
Reis e Sousa et al., London, United Kingdom. In Cell, 2010
Natural RIG-I stimulatory RNAs have variously been proposed to correspond to virus genomes, virus replication intermediates, viral transcripts, or self-RNA cleaved by RNase L. However, the relative contribution of each of these RNA species to RIG-I activation and interferon induction in virus-infected cells is not known.
How the noninflammasome NLRs function in the innate immune system.
Lei et al., Chapel Hill, United States. In Science, 2010
We discuss several of these functions, including the regulation of canonical and noncanonical NF-kappaB activation, mitogen-activated protein kinase activation, cytokine and chemokine production, antimicrobial reactive oxygen species production, type I interferon production, and ribonuclease L activity.
Interferon-inducible antiviral effectors.
Williams et al., Australia. In Nat Rev Immunol, 2008
Gene targeting studies have distinguished four main effector pathways of the IFN-mediated antiviral response: the Mx GTPase pathway, the 2',5'-oligoadenylate-synthetase-directed ribonuclease L pathway, the protein kinase R pathway and the ISG15 ubiquitin-like pathway.
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