RNA polymerase II-associated protein
RPAP3 enhances cytotoxicity of doxorubicin by impairing NF-kappa B pathway.
Suita, Japan. In Biochem Biophys Res Commun, 2011
In this study, we revealed that RPAP3 (RNA polymerase II-associated protein 3) possesses an activity to bind with NEMO and to inhibit the ubiquitination of NEMO and that RPAP3 enhances doxorubicin-induced cell death in breast cancer cell line T-47D through the marked impairment of NF-κB pathway.