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Ribosomal protein L26

ribosomal protein L26, RPL26
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p53, CAN, RPS19, ribosomal protein L11, ACID
Papers on ribosomal protein L26
Localisation of RNAs and proteins in nucleolar precursor bodies of early mouse embryos.
Zatsepina et al., In Reprod Fertil Dev, Oct 2015
Immunocytochemical assays demonstrate that zygotic NPBs contain rRNA processing factors fibrillarin, nucleophosmin and nucleolin, while UBF (the RNA polymerase I transcription factor) and ribosomal proteins RPL26 and RPS10 are not detectable.
[Molecular mechanisms underlying the pathology of Diamond-Blackfan anemia].
Ito et al., Hirosaki, Japan. In Rinsho Ketsueki, Jul 2015
In DBA, mutations or large deletions in RP genes include RPS7, RPS10, RPS17, RPS19, RPS24, RPS26, RPL5, RPL11, RPL26 and RPL35A.
Post-transcriptional regulation of ribosomal protein genes during serum starvation in Entamoeba histolytica.
Bhattacharya et al., New Delhi, India. In Mol Biochem Parasitol, Jun 2015
To investigate the regulation of RP genes under stress we measured transcription of six selected RP genes from the small- and large-ribosomal subunits (RPS6, RPS3, RPS19, RPL5, RPL26, RPL30) representing the early-, mid-, and late-stages of ribosomal assembly.
Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia.
Ito et al., Hirosaki, Japan. In Br J Haematol, Mar 2015
The disease has been associated with mutations or large deletions in 11 ribosomal protein genes including RPS7, RPS10, RPS17, RPS19, RPS24, RPS26, RPS29, RPL5, RPL11, RPL26 and RPL35A as well as GATA1 in more than 50% of patients.
Nucleolus-like bodies of fully-grown mouse oocytes contain key nucleolar proteins but are impoverished for rRNA.
Zatsepina et al., Moscow, Russia. In Dev Biol, Feb 2015
The ribosomal RPL26 protein was detected within the NLBs of NSN-type oocytes but is virtually absent from NLBs of SN-type oocytes.
The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p.
Ford et al., Aurora, United States. In Nat Commun, 2014
Instead, Six1 regulates p53 via a dual mechanism involving upregulation of microRNA-27a and downregulation of ribosomal protein L26 (RPL26).
Mod-seq: high-throughput sequencing for chemical probing of RNA structure.
McManus et al., In Rna, 2014
We further show that Mod-seq can be used to detect structural changes in 5.8S and 25S rRNAs in the absence of ribosomal protein L26, correctly identifying its binding site on the ribosome.
Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond-Blackfan anemia.
Gazda et al., Boston, United States. In Hum Genet, 2013
The disease has been associated with point mutations and large deletions in ten ribosomal protein (RP) genes RPS19, RPS24, RPS17, RPL35A, RPL5, RPL11, RPS7, RPS10, RPS26, and RPL26 and GATA1 in about 60-65 % of patients.
Coordinate transcriptional and translational repression of p53 by TGF-β1 impairs the stress response.
Emerson et al., Los Angeles, United States. In Mol Cell, 2013
TGF-β1 also causes dissociation of ribosomal protein RPL26 and elongation factor eEF1A from p53 mRNA, thereby reducing p53 mRNA association with polyribosomes and p53 translation.
Gradual processing of the ITS1 from the nucleolus to the cytoplasm during synthesis of the human 18S rRNA.
Gleizes et al., Toulouse, France. In Nucleic Acids Res, 2013
Perturbation of this step on knockdown of the large subunit ribosomal protein RPL26, which was recently associated to DBA, reveals the putative role of a highly conserved cis-acting sequence in ITS1 processing.
A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation.
Reik et al., In Genome Biol, 2012
Only a few proteins were identified with a preference for 5hmC (such as RPL26, PRP8 and the DNA mismatch repair protein MHS6), but proteins with a strong preference for 5fC were more numerous, including transcriptional regulators (FOXK1, FOXK2, FOXP1, FOXP4 and FOXI3), DNA repair factors (TDG and MPG) and chromatin regulators (EHMT1, L3MBTL2 and all components of the NuRD complex).
Silencing expression of ribosomal protein L26 and L29 by RNA interfering inhibits proliferation of human pancreatic cancer PANC-1 cells.
Chen et al., Shanghai, China. In Mol Cell Biochem, 2012
As a result, ribosomal proteins L26 and L29 (RPL26 and RPL29) were dramatically upregulated by KRAS-shRNA specifically.
Saccharomyces cerevisiae ribosomal protein L26 is not essential for ribosome assembly and function.
de la Cruz et al., Sevilla, Spain. In Mol Cell Biol, 2012
We have disrupted both genes; surprisingly, the growth of the resulting rpl26 null mutant is apparently identical to that of the isogenic wild-type strain.
Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia.
Beggs et al., Boston, United States. In Hum Mutat, 2012
Northern Blot Together with RPL5, RPL11, and RPS7, RPL26 is the fourth RP regulating p53 activity that is linked to diamond-blackfan anemia.
Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA.
Kastan et al., Memphis, United States. In J Biol Chem, 2012
suggest a model in which the base pairings in the p53 UTR interaction regions are critical for both translational repression and stress induction of p53 by NCL and RPL26
Cellular adaptation to hypoxia and p53 transcription regulation.
Du et al., Hangzhou, China. In J Zhejiang Univ Sci B, 2009
One, involving ataxia telangiectasia-mutated protein (ATM), is that the interaction between p53 and its down-regulation factor murine double minute 2 (MDM2) decreases, leading to p53 phosphorylation on Ser15, as determined by the post-translational mechanism; the other holds that p53 increases and is activated through the binding of ribosomal protein L26 (RPL26) or nucleolin to p53 mRNA 5( untranslated region (UTR), regulating p53 translation.
Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26.
Oren et al., Israel. In Mol Cell, 2008
Mdm2 binds L26 and drives its polyubiquitylation and proteasomal degradation.
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
Kastan et al., Memphis, United States. In Cell, 2005
These findings demonstrate the importance of increased translation of p53 in DNA-damage responses and suggest critical roles for RPL26 and nucleolin in affecting p53 induction.
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