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Rho GDP dissociation inhibitor

RhoGDI, RhoGDIalpha
Aplysia Ras-related homologs (ARHs), also called Rho genes, belong to the RAS gene superfamily encoding small guanine nucleotide exchange (GTP/GDP) factors. The ARH proteins may be kept in the inactive, GDP-bound state by interaction with GDP dissociation inhibitors, such as ARHGDIA (Leffers et al., 1993 [PubMed 8262133]).[supplied by OMIM, Jan 2009] (from NCBI)
Top mentioned proteins: Rhodopsin, RhoA, Rac1, Actin, Cdc42
Papers using RhoGDI antibodies
Insulin inhibits platelet-derived growth factor-induced cell proliferation
Friedmann Theodore et al., In Proteome Science, 2004
... Antibodies to Rad50, enolase, IκBKb and RhoGDI were from Santa Cruz Biotechnology (Santa Cruz, CA) and ...
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin
Kaibuchi Kozo et al., In The Journal of Cell Biology, 1996
... Anti–37-kD catalytic subunit of myosin phosphatase polyAb and anti–Rho GDI polyAb were purchased from Santa Cruz Biotechnology ...
Papers on RhoGDI
An adventitious interaction of filamin A with RhoGDI2(Tyr153Glu).
Nakamura et al., Boston, United States. In Biochem Biophys Res Commun, Feb 2016
A RhoGDI2 truncate with 81 N-terminal amino acid residues and a phosphomimetic mutant, RhoGDI(Tyr153Glu) interacted with the FLNA construct.
Structural basis of death domain signaling in the p75 neurotrophin receptor.
Ibanez et al., Singapore, Singapore. In Elife, Jan 2016
Here we report structures of complexes formed by the DD of p75 neurotrophin receptor (p75(NTR)) with RhoGDI, for activation of the RhoA pathway, with caspase recruitment domain (CARD) of RIP2 kinase, for activation of the NF-kB pathway, and with itself, revealing how DD dimerization controls access of intracellular effectors to the receptor.
Neonatal Irradiation Leads to Persistent Proteome Alterations Involved in Synaptic Plasticity in the Mouse Hippocampus and Cortex.
Tapio et al., Rotterdam, Netherlands. In J Proteome Res, Dec 2015
The proteome analysis of hippocampus, cortex, and synaptosomes isolated from these brain regions indicated changes in ephrin-related, RhoGDI, and axonal guidance signaling.
Androgen receptor promotes tamoxifen agonist activity by activation of EGFR in ERα-positive breast cancer.
Fuqua et al., Houston, United States. In Breast Cancer Res Treat, Nov 2015
We previously showed that decreased expression of Rho guanine nucleotide dissociation inhibitor (Rho GDI) α, a negative regulator of the Rho GTPase pathway, is associated with Tam resistance.
eIF5A1/RhoGDIα pathway: a novel therapeutic target for treatment of spinal cord injury identified by a proteomics approach.
Wang et al., Chengdu, China. In Sci Rep, 2014
Two of these proteins, are eukaryotic translation initiation factor 5A1 (eIF5A1) that is involved in cell survival and proliferation, and Rho GDP dissociation inhibitor alpha (RhoGDIα), a member of Rho GDI family that is involved in cytoskeletal reorganization.
Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: outsourcing a key task.
Pick, Tel Aviv-Yafo, Israel. In Small Gtpases, 2013
The superoxide-generating NADPH oxidase of phagocytes consists of the membrane-associated cytochrome b 558 (a heterodimer of Nox2 and p22(phox)) and 4 cytosolic components: p47(phox), p67(phox), p40(phox), and the small GTPase, Rac, in complex with RhoGDI.
14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins.
Ridley et al., London, United Kingdom. In Cell, 2013
Several Rho GTPases are also regulated by RhoGDI binding and sequestering in the cytosol.
Quantitative analysis of prenylated RhoA interaction with its chaperone, RhoGDI.
Alexandrov et al., Australia. In J Biol Chem, 2012
demonstrate that membrane extraction of Rho GTPase by RhoGDI is a thermodynamically favored passive process that operates through a series of progressively tighter intermediates, much like the one that is mediated by RabGDI
RhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motility.
Huang et al., New York City, United States. In J Biol Chem, 2012
The physiological regulation of RhoGDI SUMOylation by the RING domain of XIAP may account for modulation of cancer cell invasion and metastasis by XIAP
Rho GDP-dissociation inhibitor alpha is associated with cancer metastasis in colon and prostate cancer.
Tsunoda et al., Ōsaka, Japan. In Pharmazie, 2012
Rho GDI may be useful as a diagnostic biomarker and/or a therapeutic to prevent colon and prostate cancer metastasis
Knockdown of RhoGDIα induces apoptosis and increases lung cancer cell chemosensitivity to paclitaxel.
Tao et al., Suzhou, China. In Neoplasma, 2011
Knockdown of RhoGDIalpha induces apoptosis and increases lung cancer cell chemosensitivity to paclitaxel.
Ubiquitination in Rho signaling.
Wang et al., Xiamen, China. In Curr Top Med Chem, 2011
Importantly, regulators for Rho GTP-GDP cycling such as RhoGDI and Rho-GEF ECT2 were also found to be modulated by the ubiquitin pathway.
RhoGDIα-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis.
Deroanne et al., Liège, Belgium. In Mol Biol Cell, 2011
RhoGDIalpha-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis
Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells.
Ginsberg et al., San Diego, United States. In Nat Cell Biol, 2011
Ensuing PKA phosphorylation of RhoA and the resulting increased interaction between RhoA and RhoGDI (Rho GDP-dissociation inhibitor) establish a negative feedback mechanism that controls the cycling of RhoA activity at the leading edge.
Activation of the aldosterone/mineralocorticoid receptor system in chronic kidney disease and metabolic syndrome.
Nagase, Tokyo, Japan. In Clin Exp Nephrol, 2010
RhoGDIalpha knockout mice, a model with Rac1 activation in the kidney, showed albuminuria, podocyte injury, and glomerulosclerosis.
Glioma pathophysiology: insights emerging from proteomics.
Whittle et al., Edinburgh, United Kingdom. In Brain Pathol, 2010
Importantly 10 of the 99 proteins found differentially expressed in glioma [PHB, Hsp20, serum albumin, epidermal growth factor receptor (EGFR), EA-15, RhoGDI, APOA1, GFAP, HSP70, PDIA3] were identified in multiple publications.
RhoGDI signaling provides targets for cancer therapy.
Theodorescu et al., Charlottesville, United States. In Eur J Cancer, 2010
Using examples of RhoGDI-mediated signaling and expression patterns in endothelial cells as well as pancreatic, breast, and bladder cancer, the multitude of potential cancer therapeutic targets presented by a better understanding of their function is illustrated.
A RhoGDP dissociation inhibitor spatially regulates growth in root hair cells.
Dolan et al., Norwich, United Kingdom. In Nature, 2006
We cloned SCN1 and showed that SCN1 is a RhoGTPase GDP dissociation inhibitor (RhoGDI) that spatially restricts the sites of growth to a single point on the trichoblast.
Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI.
Schwartz et al., Los Angeles, United States. In Nat Cell Biol, 2002
We show that Rho-GDI, which associates with cytoplasmic GTP-Rac, blocks effector binding.
ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse.
Sperling et al., Chicago, United States. In Immunity, 2001
An ERM dominant-negative mutant blocked the distal accumulation of CD43 and another known ERM binding protein, Rho-GDI.
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