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Ras homolog gene family, member D

Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Rhodopsin, CAN, V1a, ACID, Actin
Papers on Rhod
Coated platelets function in platelet-dependent fibrin formation via integrin αIIbβ3 and transglutaminase factor XIII.
Cosemans et al., Maastricht, Netherlands. In Haematologica, Jan 2016
Here, we used a novel transglutaminase probe, Rhod-A14, to identify a subpopulation of platelets with a cross-linked protein coat, and compared this with other platelet subpopulations using a panel of functional assays.
Sex differences in the mechano-energetic effects of genistein on stunned rat and guinea pig hearts.
Consolini et al., La Plata, Argentina. In Clin Exp Pharmacol Physiol, Jan 2016
Moreover, Gen prevented the increase in Rhod-2 fluorescence (free [Ca(2+) ]m) of rat cardiomyocytes.
Nicergoline inhibits human platelet Ca(2+) signalling through triggering a microtubule-dependent reorganization of the platelet ultrastructure.
Harper et al., Stoke-on-Trent, United Kingdom. In Br J Pharmacol, Jan 2016
EXPERIMENTAL APPROACH: Thrombin-evoked Ca(2+) fluxes were monitored in Fura-2- or Fluo-5N-loaded human platelets, or using platelet suspensions containing Fluo-4 or Rhod-5N K(+) salts.
Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore Openings.
Bers et al., Davis, United States. In Circ Res, Jan 2016
The tPTP pore size is much smaller than for permanent mPTP, as neither Rhod-2 nor calcien (600 Da) were lost.
Molecular systematics and biogeography of the circumglobally distributed genus Seriola (Pisces: Carangidae).
Roodt-Wilding et al., Stellenbosch, South Africa. In Mol Phylogenet Evol, Dec 2015
This study reports the first comprehensive molecular phylogeny for this genus based on mitochondrial (Cytb) and nuclear gene (RAG1 and Rhod) DNA sequence data for all extant Seriola species (nine species, n=27).
Contributions of cardiac "funny" (f) channels and sarcoplasmic reticulum Ca2+ in regulating beating rate of mouse and guinea pig sinoatrial node.
Terrar et al., Oxford, United Kingdom. In Physiol Rep, Dec 2015
In additional experiments measuring Ca(2+) transients in the SA node region using Rhod-2, effects of ivabradine and ZD7288 on rate were again substantially reduced after CPA.
A comparison of fluorescent Ca(2+) indicators for imaging local Ca(2+) signals in cultured cells.
Smith et al., Irvine, United States. In Cell Calcium, Dec 2015
Altogether, nine synthetic Ca(2+) dyes (Fluo-4, Fluo-8, Fluo-8 high affinity, Fluo-8 low affinity, Oregon Green BAPTA-1, Cal-520, Rhod-4, Asante Calcium Red, and X-Rhod-1) and three genetically-encoded Ca(2+)-indicators (GCaMP6-slow, -medium and -fast variants) were tested; criteria include the magnitude, kinetics, signal-to-noise ratio and detection efficiency of local Ca(2+) puffs.
Genetic structure and diversity of the endangered growling grass frog in a rapidly urbanizing region.
Melville et al., Melbourne, Australia. In R Soc Open Sci, Aug 2015
We used mitochondrial DNA (mtDNA) and microsatellites to study the genetic structure and diversity of L. raniformis across Melbourne's urban fringe, and also screened four nuclear gene regions (POMC, RAG-1, Rhod and CRYBA1).
Atypical Rho GTPases RhoD and Rif integrate cytoskeletal dynamics and membrane trafficking.
Aspenström, In Biol Chem, 2014
The aim of this review is to highlight some of the recent advances in our knowledge regarding the less-studied Rho members, with the focus on RhoD and Rif.
Regulation of podocyte BK(Ca) channels by synaptopodin, Rho, and actin microfilaments.
Dryer et al., Houston, United States. In Am J Physiol Renal Physiol, 2010
Podocyte BK(Ca) channels are regulated by synaptopodin, Rho, and actin microfilaments.
Number of expressed cancer/testis antigens identifies focal adhesion pathway genes as possible targets for multiple myeloma therapy.
Colleoni et al., São Paulo, Brazil. In Leuk Lymphoma, 2010
Overexpression of RhoD is associated with multiple myeloma.
Rif proteins take to the RhoD: Rho GTPases at the crossroads of actin dynamics and membrane trafficking.
Aspenström et al., Stockholm, Sweden. In Cell Signal, 2010
The Rif and RhoD proteins belong to the Rho subfamily of small GTPases.
Repression of the estrogen receptor-alpha transcriptional activity by the Rho/megakaryoblastic leukemia 1 signaling pathway.
Flouriot et al., Rennes, France. In J Biol Chem, 2010
estrogen receptor-alpha transcriptional activity is repressed by the Rho/megakaryoblastic leukemia 1 signaling pathway
RhoA/ROK pathway related to the mechanism of higher susceptibility to spasm in RA than in IMA.
Xincun et al., Beijing, China. In J Card Surg, 2009
The expression of RhoA/Rho kinase mRNA and protein and function in the RA were significantly stronger than in the IMA, suggesting that RhoA/Rho kinase pathway may be one mechanism by which RA is more susceptible to spasm than IMA.
Stabilization of anaphase midzone microtubules is regulated by Rho during cytokinesis in human fibrosarcoma cells.
Uyeda et al., Tsukuba, Japan. In Exp Cell Res, 2009
Data suggest that mammalian cells have two potential steps that require active Rho for the stabilization of midzone microtubules during mitosis and cytokinesis.
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium.
Platt et al., Oxford, United Kingdom. In Nat Med, 2008
Chelating luminal endocytic calcium in normal cells with high-affinity Rhod-dextran induced an NPC disease cellular phenotype.
Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking.
Ridley, London, United Kingdom. In Trends Cell Biol, 2006
However, recent research indicates that several other members of the Rho family, including Rif, RhoD, TC10 and Wrch1, and also related Rho-of-plants proteins (ROPs) in plants, stimulate actin polymerization and affect plasma membrane protrusion and/or vesicular traffic.
RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase.
Zerial et al., Dresden, Germany. In Nat Cell Biol, 2003
Early endosomes move bidirectionally between the cell periphery and the interior through a mechanism regulated by the low molecular weight GTPase RhoD.
RhoD, Src, and hDia2C in endosome motility.
Randazzo, Bethesda, United States. In Dev Cell, 2003
A recent report from Marino Zerial and colleagues examining RhoD identifies mDia2C, a novel splice variant of mDia2, and Src as components of the regulatory machinery influencing actin-dependent endosome movement.
Endosome dynamics regulated by a Rho protein.
Zerial et al., Heidelberg, Germany. In Nature, 1997
A Rho protein, RhoD, might provide a molecular link between membrane traffic and the cytoskeleton.
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