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Ras homolog gene family, member C

RhoC, H-9, RhoC GTPase
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Rhodopsin, RhoA, RhoB, Actin, CAN
Papers using RhoC antibodies
Delivery of MicroRNA-10b with Polylysine Nanoparticles for Inhibition of Breast Cancer Cell Wound Healing
Lei Chenghong et al., In Breast Cancer : Basic and Clinical Research, 2009
... Antibody for RHOC was purchased from Santa Cruz Biotechnology (catalog sc-26480) ...
Automated quantitative analysis (AQUA) of in situ protein expression, antibody concentration, and prognosis.
Anderson Kurt I., In PLoS ONE, 2004
... RhoC shRNA and the scrambled control plasmid came from Origene and were obtained through ...
The PredictProtein server.
Delprato Anna Maria, In PLoS ONE, 2003
... Antibodies: anti-GST (Sigma), anti-RhoC (Cell Signaling), anti-GFP (Clontech), anti-β-actin (Sigma), ...
Activity of Rho-family GTPases during cell division as visualized with FRET-based probes
Ridley Anne J. et al., In The Journal of Cell Biology, 2002
... University of North Carolina at Chapel Hill, Chapel Hill, NC), rabbit anti-RhoA (26C4), anti-RhoB, goat anti-RhoC (Santa Cruz Biotechnology, Inc.), sheep anti-RhoF (provided ...
Papers on RhoC
The Role of RhoA, RhoB and RhoC GTPases in Cell Morphology, Proliferation and Migration in Human Cytomegalovirus (HCMV) Infected Glioblastoma Cells.
Sourvinos et al., Irákleion, Greece. In Cell Physiol Biochem, Feb 2016
METHODS: RhoA, RhoB and RhoC were individually depleted in U373MG glioblastoma cells as well as U373MG cells stably expressing the HCMV IE1 protein (named U373MG-IE1 cells) shRNA lentivirus vectors.
MicroRNA-372 inhibits endometrial carcinoma development by targeting the expression of the Ras homolog gene family member C (RhoC).
Zhao et al., Shenyang, China. In Oncotarget, Jan 2016
Bioinformatic predictions and dual-luciferase reporter assays found that RhoC was a possible target of miR-372.
Chronic ethanol exposure enhances the aggressiveness of breast cancer: the role of p38γ.
Luo et al., Lexington, United States. In Oncotarget, Jan 2016
Ethanol selectively activated p38γ MAPK and RhoC but not p38α/β in a concentration-dependent manner.
MiR-493 suppresses the proliferation and invasion of gastric cancer cells by targeting RhoC.
He et al., Hengyang, China. In Iran J Basic Med Sci, Oct 2015
In addition, miR-493 directly targeted RhoC, which resulted in a marked reduction of the expression of mRNA and protein.
RhoC is essential in TGF-β1 induced epithelial-mesenchymal transition in cervical cancer cells.
Wang et al., Wuhan, China. In Oncol Lett, Aug 2015
The present study aimed to investigate the role of Ras homolog gene family, member C (RhoC) guanosine triphosphatase (GTPase) in transforming growth factor (TGF)-β1 induced EMT.
The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease.
Lutz et al., Göttingen, Germany. In Front Pharmacol, 2014
Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are downstream targets of the small GTPases RhoA, RhoB, and RhoC.
Epigenetics meets genetics in acute myeloid leukemia: clinical impact of a novel seven-gene score.
Bloomfield et al., Rochester, United States. In J Clin Oncol, 2014
RESULTS: In the training set, we identified seven genes (CD34, RHOC, SCRN1, F2RL1, FAM92A1, MIR155HG, and VWA8) with promoter DMRs and expression associated with overall survival (OS; P ≤ .001).
Toward understanding RhoGTPase specificity: structure, function and local activation.
Hordijk et al., Amsterdam, Netherlands. In Small Gtpases, 2013
RhoA, RhoB, and RhoC are highly homologous GTPases that, however, succeed in generating specific intracellular responses.
Rho GTPase isoforms in cell motility: Don't fret, we have FRET.
Hodgson et al., United States. In Cell Adh Migr, 2013
Currently, it is possible to specifically detect the activation status of RhoA vs. RhoC isoforms, as well as Cdc42 vs.
Rho-associated coiled-coil containing kinases (ROCK): structure, regulation, and functions.
Olson et al., Glasgow, United Kingdom. In Small Gtpases, 2013
(1)(-) (5) They belong to the AGC family of serine/threonine kinases (6) and play vital roles in facilitating actomyosin cytoskeleton contractility downstream of RhoA and RhoC activation.
Spatial regulation of tumor cell protrusions by RhoC.
Condeelis et al., United States. In Cell Adh Migr, 2013
Recent studies have shown that the signaling molecules including RhoC/p190RhoGEF/p190RhoGAP acts as a "molecular compass" in order to direct the spatial and temporal dynamics of the formation of these invasive and locomotory protrusions leading to efficient invasion.
The interaction of PKN3 with RhoC promotes malignant growth.
Klippel et al., Pearl River, United States. In Mol Oncol, 2012
Data demonstrate that PKN3 physically interacts with Rho-family GTPases, and preferentially with RhoC, a known mediator of tumor invasion and metastasis in epithelial cancers.
miR-10b promotes cell invasion through RhoC-AKT signaling pathway by targeting HOXD10 in gastric cancer.
Fang et al., Changchun, China. In Int J Oncol, 2012
Suggest that miR-10b can stimulate the upregulation of RhoC and AKT phosphorylation through targeting HOXD10, thus promoting cell invasion in gastric tumors.
Neuroanatomical distribution of the orphan GPR50 receptor in adult sheep and rodent brains.
Migaud et al., France. In J Neuroendocrinol, 2012
An enlarged distribution of GPR50 protein in the brain.
A role for the melatonin-related receptor GPR50 in leptin signaling, adaptive thermogenesis, and torpor.
Loudon et al., Manchester, United Kingdom. In Curr Biol, 2012
GPR50 is a component of adaptive thermogenesis in mice
Tumor suppressor microRNA-493 decreases cell motility and migration ability in human bladder cancer cells by downregulating RhoC and FZD4.
Dahiya et al., San Francisco, United States. In Mol Cancer Ther, 2012
miR-493 is a new tumor suppressor miRNA in bladder cancer and inhibits cell motility through downregulation of RhoC and FZD4.
Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility.
Sahai et al., London, United Kingdom. In Nat Cell Biol, 2009
TGFbeta1 switches cells from cohesive to single cell motility through a transcriptional program involving Smad4, EGFR, Nedd9, M-RIP, FARP and RhoC.
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer.
Weinberg et al., Cambridge, United States. In Nature, 2007
The miR-10b induced by Twist proceeds to inhibit translation of the messenger RNA encoding homeobox D10, resulting in increased expression of a well-characterized pro-metastatic gene, RHOC.
Structural and mechanistic insights into the interaction between Rho and mammalian Dia.
Wittinghofer et al., Dortmund, Germany. In Nature, 2005
Here we present the crystal structure of RhoC in complex with the regulatory N terminus of mammalian Diaphanous 1 (mDia1) containing the GBD/FH3 region, an all-helical structure with armadillo repeats.
Genomic analysis of metastasis reveals an essential role for RhoC.
Hynes et al., Cambridge, United States. In Nature, 2000
One of these, the small GTPase RhoC, enhances metastasis when overexpressed, whereas a dominant-negative Rho inhibits metastasis.
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