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Rha, ATP-dependent RNA helicase, NDH II, Nuclear DNA helicase II
This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.[provided by RefSeq, Feb 2010] (from NCBI)
Top mentioned proteins: ACID, CAN, ATPase, HAD, fibrillin-1
Papers on Rha
Synthesis of a Liposomal MUC1 Glycopeptide-Based Immunotherapeutic and Evaluation of the Effect of l-Rhamnose Targeting on Cellular Immune Responses.
Sucheck et al., Toledo, United States. In Bioconjug Chem, Feb 2016
We hypothesize that improved antigen uptake of a glycopeptide sequence containing a CD8(+) T cell epitope could be achieved by delivering it on a liposome surface decorated with an immune complex-targeting ligand, an l-Rhamnose (Rha) epitope.
The RNA Helicase RHAU (DHX36) Interacts with the 3' tail of the Long Non-coding RNA BC200 (BCYRN1).
McKenna et al., Canada. In J Biol Chem, Feb 2016
UNASSIGNED: RHAU is an ATP-dependent RNA helicase that demonstrates high affinity for quadruplex structures in DNA and RNA.
Quantitative Tissue Proteomics Analysis Reveals Versican as Potential Biomarker for Early-Stage Hepatocellular Carcinoma.
Sitek et al., Bochum, Germany. In J Proteome Res, Feb 2016
We present the overexpression of ATP-dependent RNA helicase (DDX39), Fibulin-5 (FBLN5), myristoylated alanine-rich C-kinase substrate (MARCKS), and Serpin H1 (SERPINH1) in HCC for the first time.
period-1 encodes an ATP-dependent RNA helicase that influences nutritional compensation of the Neurospora circadian clock.
Dunlap et al., Hannover, Germany. In Proc Natl Acad Sci U S A, Jan 2016
PRD-1 is an RNA helicase whose orthologs, DDX5 [DEAD (Asp-Glu-Ala-Asp) Box Helicase 5] and DDX17 in humans and DBP2 (Dead Box Protein 2) in yeast, are implicated in various processes, including transcriptional regulation, elongation, and termination, ribosome biogenesis, and mRNA decay.
Selective Hyaluronan-CD44 Signaling Promotes miRNA-21 Expression and Interacts with Vitamin D Function during Cutaneous Squamous Cell Carcinomas Progression Following UV Irradiation.
Bikle et al., San Francisco, United States. In Front Immunol, 2014
The aim of this hypothesis and theory article is to question whether matrix HA and its UVR-induced catabolic products (e.g., large and small HA) can selectively activate CD44-mediated cellular signaling such as GTPase (Rac and RhA) activation.
Antitumor Effects and Mechanism of Novel Emodin Rhamnoside Derivatives against Human Cancer Cells In Vitro.
Liu et al., Guangzhou, China. In Plos One, 2014
We found that one derivative S-8 (EM-d-Rha) strongly inhibited cell proliferation of a panel of different human cancer cell lines including A549, HepG2, OVCAR-3, HeLa and K562 and SGC-790 cell lines, and displayed IC50 values in low micro-molar ranges, which are ten folds more effective than emodin.
The role of the poly(A) binding protein in the assembly of the Cap-binding complex during translation initiation in plants.
Gallie, Riverside, United States. In Translation (austin), 2014
eIF4B promotes the ATP-dependent RNA helicase activity of eIF4A and eIF4F needed to unwind secondary structure present in a 5'-leader that would otherwise impede scanning of the 40 S subunit during initiation.
Staufen-mediated mRNA decay.
Maquat et al., Rochester, United States. In Wiley Interdiscip Rev Rna, 2013
Both STAU1 and STAU2 interact directly with the ATP-dependent RNA helicase UPF1, a key SMD factor, enhancing its helicase activity to promote effective SMD.
DEAD box RNA helicase functions in cancer.
Fuller-Pace, Dundee, United Kingdom. In Rna Biol, 2013
Members of the DEAD box family of RNA helicases are known to be involved in most cellular processes that require manipulation of RNA structure and, in many cases, exhibit other functions in addition to their established ATP-dependent RNA helicase activities.
RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation.
Lahesmaa et al., Turku, Finland. In Stem Cells, 2012
L1TD1 is part of the L1TD1-RHA-LIN28 complex that could influence levels of OCT4, suggesting that L1TD1 has an important role in the regulation of stemness.
Identification of RNA helicase A as a cellular factor that interacts with influenza A virus NS1 protein and its role in the virus life cycle.
Zhou et al., Saskatoon, Canada. In J Virol, 2012
RNA helicase A as a cellular factor that interacts with influenza A virus NS1 protein and its role in the virus life cycle.
A novel role of RNA helicase A in regulation of translation of type I collagen mRNAs.
Stefanovic et al., Tallahassee, United States. In Rna, 2012
RNA helicase A (RHA) is tethered to the 5' SL of collagen mRNAs by interaction with the C-terminal domain of LARP6.
DHX9 pairs with IPS-1 to sense double-stranded RNA in myeloid dendritic cells.
Liu et al., Houston, United States. In J Immunol, 2011
DHX9 is an important RNA sensor that is dependent on interferon-beta promoter stimulator (IPS)-1 to sense pathogenic RNA.
The multiple hats of Vasa: its functions in the germline and in cell cycle progression.
Wessel et al., Providence, United States. In Mol Reprod Dev, 2011
Vasa, an ATP-dependent RNA helicase, is broadly conserved among various organisms from cnidarians to mammals.
Human DHX9 helicase preferentially unwinds RNA-containing displacement loops (R-loops) and G-quadruplexes.
Grosse et al., Jena, Germany. In Dna Repair (amst), 2011
DHX9 also unwound RNA-based G-quadruplexes that have been reported to occur in human transcripts
Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation.
Sonenberg et al., Montréal, Canada. In Nature, 1998
eIF4F is itself a three-subunit complex comprising the cap-binding protein eIF4E, eIF4A, an ATP-dependent RNA helicase, and eIF4G, which interacts with both eIF4A and eIF4E and enhances cap binding by eIF4E.
A suppressor of a yeast splicing mutation (prp8-1) encodes a putative ATP-dependent RNA helicase.
Beggs et al., Edinburgh, United Kingdom. In Nature, 1991
The predicted amino-acid sequence of the SPP81 protein shows extensive similarity to a recently identified family of proteins thought to possess ATP-dependent RNA helicase activity.
The Xenopus localized messenger RNA An3 may encode an ATP-dependent RNA helicase.
Weeks et al., Iowa City, United States. In Nature, 1991
We show here that An3 mRNA encodes a protein with 74% identity to a protein encoded by the testes-specific mRNA PL10 found in mouse, which is proposed to have RNA helicase activity.
The protein encoded by a murine male germ cell-specific transcript is a putative ATP-dependent RNA helicase.
Fellous et al., Paris, France. In Cell, 1989
The murine PL10 cDNA corresponds to a transcript expressed only in the male germ line.
Nuclear protein with sequence homology to translation initiation factor eIF-4A.
Lane et al., Schwäbisch Hall, Germany. In Nature, 1988
The sequence similarity between p68 and eIF-4A is interesting because eIF-4A acts as an ATP-dependent RNA helicase and T antigen is an ATP-dependent DNA helicase.
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