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Rh-associated glycoprotein

Rh2, Rh50, RHAG, Rh-associated glycoprotein
The protein encoded by this gene is erythrocyte-specific and is thought to be part of a membrane channel that transports ammonium and carbon dioxide across the blood cell membrane. The encoded protein appears to interact with Rh blood group antigens and Rh30 polypeptides. Defects in this gene are a cause of regulator type Rh-null hemolytic anemia (RHN), or Rh-deficiency syndrome.[provided by RefSeq, Mar 2009] (from NCBI)
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Top mentioned proteins: CAN, ACID, V1a, CD45, HAD
Papers on Rh2
Mechanism of Rh2(II)-Catalyzed Indole Formation: The Catalyst Does Not Control Product Selectivity.
Tantillo et al., Davis, United States. In J Am Chem Soc, Feb 2016
Possible mechanisms for Rh-promoted indole formation from vinyl/azidoarenes were examined computationally, and a mechanism is proposed in which the Rh catalyst promotes generation of a nitrene but is not directly involved in cyclization.
Rh-Catalyzed Intermolecular Reactions of α-Alkyl-α-Diazo Carbonyl Compounds with Selectivity over β-Hydride Migration.
Fox et al., Newark, United States. In Acc Chem Res, Feb 2016
Rh-carbenes derived from α-diazocarbonyl compounds have found broad utility across a remarkable range of reactivity, including cyclopropanation, cyclopropenation, C-H insertions, heteroatom-hydrogen insertions, and ylide forming reactions.
Anti-Inflammatory Effects of Ginsenoside-Rh2 Inhibits LPS-Induced Activation of Microglia and Overproduction of Inflammatory Mediators Via Modulation of TGF-β1/Smad Pathway.
Park et al., Kyŏngju, South Korea. In Neurochem Res, Feb 2016
UNASSIGNED: Microglia activation plays an important role in neuroinflammation and contributes to several neurological disorders.
Combined Effect of Sodium Selenite and Ginsenoside Rh2 on HCT116 Human Colorectal Carcinoma Cells.
Li et al., Nantong, China. In Arch Iran Med, Jan 2016
BACKGROUND: Sodium selenite and ginsenoside Rh2 (G-Rh2) are well known for their anticancer properties and have been exploited as a new therapeutic approach.
Semisynthesis and bioactive evaluation of oxidized products from 20(S)-ginsenoside Rg3, Rh2, protopanaxadiol (PPD) and their 20(R)-epimers as cytotoxic agents.
Li et al., Changchun, China. In Steroids, Jan 2016
UNASSIGNED: A series of oxidized products have been systematically semisynthesized from 20(S)-ginsenoside Rg3, Rh2, 20(S)-protopanaxadiol (PPD) and their 20(R)-epimers and the majority of these products were evaluated for their cytotoxic activity against HeLa cells and HepG2 cells by MTT assay for the first time.
Ginsenoside Rh2 inhibits hepatocellular carcinoma through β-catenin and autophagy.
Zhang et al., Chongqing, China. In Sci Rep, Dec 2015
Ginsenoside Rh2 (GRh2) has been shown to significantly inhibit growth of some types of cancer, whereas its effects on HCC have not been examined.
Ammonia transport in the kidney by Rhesus glycoproteins.
Verlander et al., Gainesville, United States. In Am J Physiol Renal Physiol, 2014
The erythroid-specific Rhesus glycoprotein, Rh A Glycoprotein (Rhag), was the first Rhesus glycoprotein recognized as an ammonia-specific transporter.
Effects and mechanisms of ginseng and ginsenosides on cognition.
Whalley et al., Reading, United Kingdom. In Nutr Rev, 2014
However, mechanistic results are encouraging; in particular, the ginsenosides Rg3 , Rh1 , Rh2 , Rb1 , Rd, Rg2 , and Rb3 , along with the aglycones protopanaxadiol and protopanaxatriol, warrant further attention.
Direct spectroscopic characterization of a transitory dirhodium donor-acceptor carbene complex.
Berry et al., Madison, United States. In Science, 2013
A multitude of organic transformations catalyzed by dirhodium(II) (Rh2) complexes are thought to proceed via the intermediacy of highly reactive, electrophilic carbenoid intermediates that have eluded direct observation.
Disorders of red cell volume regulation.
Gallagher, New Haven, United States. In Curr Opin Hematol, 2013
Recent studies have implicated roles for a new protein PIEZO1, a long sought after mammalian mechanosensory protein; GLUT1, the glucose transporter; SLC4A1, the anion transporter; RhAG, the Rh-associated glycoprotein; and ABCB6, an ATP-binding cassette family member.
Pharmacokinetics-pharmacology disconnection of herbal medicines and its potential solutions with cellular pharmacokinetic-pharmacodynamic strategy.
Wang et al., Nanjing, China. In Curr Drug Metab, 2012
Finally, our successful applications of cellular pharmacokinetic-pharmacodynamic strategy in elucidating ginsenoside Rh2 as an adjuvant agent and tanshinone IIA as an anticancer agent are illustrated.
Expression of the Rh/RhAG complex is reduced in Mi.III erythrocytes.
Lin et al., Taiwan. In Vox Sang, 2012
Substitution of GPB with Gp.Mur significantly reduced the expression of Rh antigen and RhAG on the Mi.III(+/+) erythrocyte membrane
Human RhAG ammonia channel is impaired by the Phe65Ser mutation in overhydrated stomatocytic red cells.
Mouro-Chanteloup et al., Paris, France. In Am J Physiol Cell Physiol, 2012
Results provide new insights into the functional impact of the Phe65Ser mutation in RhAG.
A family study of the Chinese Rhnull individual of the regulator type: a novel single missense mutation identified in RHAG gene.
Hou et al., Chengdu, China. In Transfusion, 2011
that the 672C>A missense mutation in the RHAG gene could result in Rh(null) of the regulator type, and the single-amino-acid change (Ser to Arg) might be critical for assembly of the Rh antigen complex within the membrane
Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S.
Alper et al., Boston, United States. In Am J Physiol Cell Physiol, 2011
The results provide new insight into RhAG stomatocytosis mutant F65S as a combined loss-of-function/gain-of-function mutation for methylammonium/methylammonium+ transport
Nitrogen excretion in developing zebrafish (Danio rerio): a role for Rh proteins and urea transporters.
Perry et al., Ottawa, Canada. In Am J Physiol Renal Physiol, 2009
is required to facilitate normal ammonia excretion in the zebrafish larva
Early evolution of vertebrate photoreception: lessons from lampreys and lungfishes.
Collin, Brisbane, Australia. In Integr Zool, 2009
Each receptor type also contains a different visual pigment (opsin gene); that is, LWS, SWS1, SWS2, RhA and RhB in G. australis and LWS, SWS1, SWS2, Rh1 and Rh2 in N. forsteri, all of which are expressed within the retina and are sensitive to different parts of the electromagnetic spectrum, providing the potential for pentachromatic and tetrachromatic color vision, respectively.
Candidate gene acting as a suppressor of the RH locus in most cases of Rh-deficiency.
Cartron et al., Paris, France. In Nat Genet, 1996
The Rh antigen is a multi-subunit complex composed of Rh polypeptides and associated glycoproteins (Rh50, CD47, LW and glycophorin B); these interact in the red cell membrane and are lacking or severely reduced in Rhnull cells.
Transcript localization of four opsin genes in the three visual organs of Drosophila; RH2 is ocellus specific.
Benzer et al., Pasadena, United States. In Nature, 1988
Four opsin genes have been identified thus far in Drosophila; Rh1, Rh2, Rh3 and Rh4 (refs 6-11).
Ectopic expression of a minor Drosophila opsin in the major photoreceptor cell class: distinguishing the role of primary receptor and cellular context.
Rubin et al., Berkeley, United States. In Cell, 1988
A transcriptional fusion between the ninaE promoter and the structural gene for a minor opsin (Rh2) that is not normally expressed in the R1-R6 photoreceptor cells was used to demonstrate that Rh2 rhodopsin can photoactivate the R1-R6 transduction cascade, but with different spectral sensitivity.
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