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Regulator of G-protein signaling 8

activates GTPase; inhibits G-protein coupled receptor signaling; modulates activity of G-protein-coupled inwardly rectifying K+ channels [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: RGS, RGS4, RGS2, CAN, RGS7
Papers on RGS8
Structure of the Regulator of G Protein Signaling 8 (RGS8)-Gαq Complex: Molecular Basis for Gα Selectivity.
Tesmer et al., United States. In J Biol Chem, Feb 2016
To resolve this ambiguity, the 2.6 Å crystal structure of RGS8, an R4 subfamily member, was determined in complex with Gαq.
Potent inhibition of angiotensin AT1 receptor signaling by RGS8: importance of the C-terminal third exon part of its RGS domain.
Kimura et al., Chiba, Japan. In J Recept Signal Transduct Res, Feb 2016
To evaluate intrinsic potency of these RGS proteins, we compared inhibitory effects of RGS1, RGS2, RGS3, RGS4, RGS5, RGS8 and RGS16 on AT1 receptor signaling.
The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration.
Chen et al., Winston-Salem, United States. In Neuroscience, Nov 2015
Although there were significant changes in the mRNA levels of RGS7 and RGS8 in the NAc, none of these measures were correlated with the rate of AMPH intake.
Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse model.
Pulst et al., Salt Lake City, United States. In Plos Genet, Apr 2015
Transcriptome analysis by deep RNA-sequencing revealed that BAC-Q72 mice had progressive changes in steady-state levels of specific mRNAs including Rgs8, one of the earliest down-regulated transcripts in the Pcp2-ATXN2[Q127] mouse line.
Amphetamine self-administration attenuates dopamine D2 autoreceptor function.
Chen et al., Winston-Salem, United States. In Neuropsychopharmacology, 2014
AMPH had no effects on the midbrain expression and trafficking of other RGS proteins such as RGS4 and RGS8.
Regulator of G protein signaling transcript expression in human neural progenitor differentiation: R7 subfamily regulation by DNA methylation.
Hooks et al., Athens, United States. In Neurosignals, 2013
Further, we showed that direct pharmacological inhibition of DNMT activity enhances expression of RGS2, RGS4, RGS5, RGS6, RGS7, RGS8, RGS9L, RGS10, and RGS14 as well as R7BP and R9AP transcripts in progenitors, consistent with regulation by DNMTs.
RGS expression in cancer: oncomining the cancer microarray data.
Dulin et al., Chicago, United States. In J Recept Signal Transduct Res, 2013
We focused on the largest R4 sub-family of RGS proteins, containing RGS1, RGS2, RGS3, RGS4, RGS5, RGS8, RGS13, RGS16 and RGS18.
A high throughput screen for RGS proteins using steady state monitoring of free phosphate formation.
Roman et al., Iowa City, United States. In Plos One, 2012
In this study we developed a simple and inexpensive assay for the steady state analysis of RGS protein GAP activity, using RGS4, RGS8 and RGS17 as models.
Small Molecule Inhibitors of Regulator of G Protein Signalling (RGS) Proteins.
Husbands et al., Bath, United Kingdom. In Acs Med Chem Lett, 2012
The newly developed ligands (11b, 13) display substantial selectivity over the closely related RGS8 protein, lack the off-target calcium mobilisation activity of the lead 1a and have excellent aqueous solubility.
A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins.
Neubig et al., Ann Arbor, United States. In Biochemistry, 2011
Analysis of the cysteine reactivity of the compound shows that compound binding to Cys(107) in RGS8 inhibits Gα binding in a manner that can be reversed by cleavage of the compound-RGS disulfide bond.
High-resolution melting analysis for mutation screening of RGSL1, RGS16, and RGS8 in breast cancer.
Hansen et al., Århus, Denmark. In Cancer Epidemiol Biomarkers Prev, 2011
Missense mutations in RGS8 gene is associated with breast cancer.
RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling.
Siderovski et al., Chapel Hill, United States. In Am J Physiol Cell Physiol, 2010
Surprisingly, we found that knockdown of RGS8 and RGS9, but not other conventional RGS proteins, significantly decreased carbachol-mediated calcium mobilization, whereas only RGS8 knockdown decreased protease-activated receptor-1 (PAR-1)-mediated calcium mobilization.
Functional interaction of regulator of G protein signaling-2 with melanin-concentrating hormone receptor 1.
Saito et al., Hiroshima, Japan. In Ann N Y Acad Sci, 2010
We previously elucidated that RGS8 of the B/R4 RGS subfamily potently inhibits the action of both Galphaq- and Galphai/o-dependent MCHR1 signaling.
A simple way to evaluate self-designed probes for tumor specific Multiplex Ligation-dependent Probe Amplification (MLPA).
Hansen et al., Århus, Denmark. In Bmc Res Notes, 2009
To test the calculation strategy, three probes were designed to cover regions in Regulator of G-protein Signaling 8 (RGS8), which we previously have identified as being affected by allelic imbalance by LOH analysis across RGS8 in the cohort comprising 145 breast tumors.
Spinophilin inhibits the binding of RGS8 to M1-mAChR but enhances the regulatory function of RGS8.
Saitoh et al., Nagahama, Japan. In Biochem Biophys Res Commun, 2009
Spinophilin was identified as an RGS8-interacting protein.
Generation of RGS8 null mutant mice by Cre/loxP system.
Aiba et al., Kōbe, Japan. In Kobe J Med Sci, 2006
RGS8 null mutant mice were viable, fertile and showed apparently normal development
RGS8 expression in developing cerebellar Purkinje cells.
Odagiri et al., Fuchū, Japan. In Biochem Biophys Res Commun, 2003
examination of expression of mRNA in developing cerebellum by in situ hybridization
Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling.
Kubo et al., Fuchū, Japan. In Proc Natl Acad Sci U S A, 2002
Alternative splicing determines inhibitory function of receptor type-specific Gq signaling.
RGS8 accelerates G-protein-mediated modulation of K+ currents.
Nakata et al., Tokyo, Japan. In Nature, 1998
Here we report the isolation of a full-length complementary DNA encoding a neural-tissue-specific RGS protein, RGS8, and the determination of its function.
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