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Regulator of G-protein signaling 7

acts as a GTPase activating protein; regulates activation and deactivation kinetics of G-protein coupled inward rectifier K+ channel; binds Galphao; Galphai3, and Galphaz [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: RGS, RGS9, RGS4, CAN, HAD
Papers on RGS7
Roles for Regulator of G Protein Signaling Proteins in Synaptic Signaling and Plasticity.
Hepler et al., Atlanta, United States. In Mol Pharmacol, Feb 2016
Here, we review and highlight the current knowledge of specific RGS proteins (RGS2, RGS4, RGS7, RGS9-2, and RGS14) that have been clearly demonstrated to serve critical roles in modulating synaptic signaling and plasticity throughout the brain, and we consider their potential as future therapeutic targets.
The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration.
Chen et al., Winston-Salem, United States. In Neuroscience, Nov 2015
AMPH self-administration also produced a negative correlation of the mRNA levels of RGS7 and RGS19 between the two brain regions, which was not present in the control group.
Intelligence: shared genetic basis between Mendelian disorders and a polygenic trait.
Boomsma et al., Amsterdam, Netherlands. In Eur J Hum Genet, Oct 2015
Using both single-nucleotide polymorphism (SNP)- and gene-based association testing, we detected an association between intelligence and the genes of interest, with genes ELP2, TMEM135, PRMT10, and RGS7 showing the strongest associations.
Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum.
Martemyanov et al., Jupiter, United States. In Biol Psychiatry, Sep 2015
METHODS: We used genetic approaches to ablate regulator of G-protein signaling 7 (RGS7) both globally and in specific neuronal populations.
LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation.
Zeitz et al., Paris, France. In Eur J Neurosci, Aug 2015
mGluR6, GPR179, RGS7, RGS11 and Gβ5 immunofluorescence was absent at the dendritic tips of cone ON-bipolar cells in Lrit3(nob6/nob6) mice, while it was present at the dendritic tips of rod bipolar cells.
Fine mapping of the uterine leiomyoma locus on 1q43 close to a lncRNA in the RGS7-FH interval.
Wiener et al., Amsterdam, Netherlands. In Endocr Relat Cancer, Aug 2015
We report promising susceptibility associations with UL peaking at rs78220092 (P=7.0×10(-5)) in the RGS7-FH interval in African Americans.
Synaptic pathology and therapeutic repair in adult retinoschisis mouse by AAV-RS1 transfer.
Sieving et al., In J Clin Invest, Aug 2015
Specifically, the TRPM1 channel and G proteins Gαo, Gβ5, and RGS11 were progressively lost from postsynaptic DBC dendritic tips, whereas the mGluR6 receptor and RGS7 maintained proper synaptic position.
Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the Brain.
Martemyanov et al., Albacete, Spain. In J Biol Chem, Jun 2015
A member of this family, RGS7, plays a critical role in the nervous system where it regulates multiple neurotransmitter GPCRs that mediate vision, memory, and the action of addictive drugs.
Helix 8 and the i3 loop of the muscarinic M3 receptor are crucial sites for its regulation by the Gβ5-RGS7 complex.
Slepak et al., Miami, United States. In Biochemistry, Mar 2015
One of these molecules is Gβ5-RGS7, the permanently associated heterodimer of G protein β-subunit Gβ5 and RGS7, a regulator of G protein signaling.
RGS Protein Regulation of Phototransduction.
Chen, Houston, United States. In Prog Mol Biol Transl Sci, 2014
The role of RGS in vision has also been established a synapse away in retinal depolarizing bipolar cells (DBCs), where RGS7 and RGS11 work redundantly and in a complex with Gβ5-S as GAPs for Goα in the metabotropic glutamate receptor 6 pathway situated at DBC dendritic tips.
Localized, non-random differences in chromatin accessibility between homologous metaphase chromosomes.
Knoll et al., London, Canada. In Mol Cytogenet, 2013
Differences in hybridization between homologs were non-random for 8 genomic regions (RGS7, CACNA1B, GABRA5, SNRPN, HERC2, PMP22:IVS3, ADORA2B:IVS1, ACR) and were not unique to known imprinted domains or specific chromosomes.
Subcellular localization of regulator of G protein signaling RGS7 complex in neurons and transfected cells.
Slepak et al., Miami, United States. In J Neurochem, 2012
This study demonistrated that the subcellular localization of RGS7 in neurons and found that a significant fraction is present in cytoplasmic puncta.
Regulators of G protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons.
Martemyanov et al., Jupiter, United States. In Proc Natl Acad Sci U S A, 2012
RGS7 and RGS11 are the key GTPase accelerating proteins in the mGluR6 pathway of retinal rod ON bipolar cells that set the sensitivity and time course of light-evoked responses.
Defective retinal depolarizing bipolar cells in regulators of G protein signaling (RGS) 7 and 11 double null mice.
Chen et al., Richmond, United States. In J Biol Chem, 2012
Defective retinal depolarizing bipolar cells in regulators of G protein signaling (RGS) 7 and 11 double null mice.
Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.
Blumer et al., Saint Louis, United States. In J Biol Chem, 2011
Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.
Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling.
Martemyanov et al., Minneapolis, United States. In Nat Neurosci, 2010
study found that RGS7-Gbeta5 complexes bound to G protein-gated potassium channels and facilitated their functional coupling to GABA(B) receptors in neurons
R9AP and R7BP: traffic cops for the RGS7 family in phototransduction and neuronal GPCR signaling.
Blumer et al., Saint Louis, United States. In Trends Pharmacol Sci, 2009
Particularly intriguing are members of the RGS7 (R7) family (RGS6, RGS7, RGS9 and RGS11), which heterodimerize with Gbeta5.
The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling.
Martemyanov et al., Minneapolis, United States. In Cell Biochem Biophys, 2008
Four proteins in this group, RGS6, RGS7, RGS9, and RGS11, share a common molecular organization of three modules: (i) the catalytic RGS domain, (ii) a GGL domain that recruits G beta(5), an outlying member of the G protein beta subunit family, and (iii) a DEP/DHEX domain that mediates interactions with the membrane anchor proteins R7BP and R9AP.
Clinical report of a pure subtelomeric 1qter deletion in a boy with mental retardation and multiple anomalies adds further evidence for a specific phenotype.
Kooy et al., Antwerp, Belgium. In Am J Med Genet A, 2005
In addition, the breakpoint region was mapped to a 26 kb region within the RGS7 gene.
Upregulation of RGS7 may contribute to tumor necrosis factor-induced changes in central nervous function.
Kim et al., Boston, United States. In Nat Med, 1999
Here we demonstrate that tumor necrosis factor (TNF)-alpha, an essential mediator of endotoxin-induced sepsis, prevents the proteasome-dependent degradation of RGS7, a regulator of G-protein signaling.
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