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Regulator of G-protein signaling 17

RGS17, RGSZ2, hRGS17
This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: RGS, RGSZ1, V1a, mu-opioid receptor, GAP
Papers on RGS17
The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration.
Chen et al., Winston-Salem, United States. In Neuroscience, Nov 2015
Additionally, the rate of AMPH intake was also positively correlated with RGS10 and negatively correlated with RGS17 and the short form of D2Rs mRNA level in the VTA.
The σ1 receptor engages the redox-regulated HINT1 protein to bring opioid analgesia under NMDA receptor negative control.
Garzón et al., Madrid, Spain. In Antioxid Redox Signal, May 2015
RESULTS: The MOR C terminus carries the histidine triad nucleotide-binding protein 1 (HINT1) coupled to the regulator of G-protein signaling RGSZ2-neural nitric oxide synthase assembly.
Integrative epigenomic and genomic filtering for methylation markers in hepatocellular carcinomas.
Santella et al., New York City, United States. In Bmc Med Genomics, 2014
Another two genes (RGS17 and NR2E1) at Chr6q showed significantly decreased DNA methylation in tumors with loss of DNA copy number compared to those without, suggesting alternative roles of DNA copy number losses and hypermethylation in the regulation of RGS17 and NR2E1.
Use of a High-Density Protein Microarray to Identify Autoantibodies in Subjects with Type 2 Diabetes Mellitus and an HLA Background Associated with Reduced Insulin Secretion.
Krakoff et al., Carlsbad, United States. In Plos One, 2014
PPARG2 and UBE2M had lowest p-values (adjusted p = 0.023) while PPARG2 and RGS17 had highest case-to-control antibody signal ratios (1.7).
Deregulation of RGS17 Expression Promotes Breast Cancer Progression.
Zhao et al., Shanghai, China. In J Cancer, 2014
OBJECTIVE: A high level of RGS17 expression is observed in diverse human cancers and correlates with tumor progression.
Analysis of candidate genes for morphine preference quantitative trait locus Mop2.
Ferraro et al., Philadelphia, United States. In Neuroscience, 2014
Real-time qRT-PCR analysis of Oprm1 and opioid-related genes Rgs17, Ppp1r14c, Vip, and Iyd revealed both between-strain and within-strain expression differences in comparisons of saline- and morphine-treated B6 and D2 mice.
Nitric oxide and zinc-mediated protein assemblies involved in mu opioid receptor signaling.
Garzón et al., Madrid, Spain. In Mol Neurobiol, 2013
The NMDAR NR1 subunit and the regulator of G protein signaling RGSZ2 bind HINT1 in a zinc-independent manner, with RGSZ2 associating with nNOS and regulating MOR-induced production of NO.
RGS17: an emerging therapeutic target for lung and prostate cancers.
Roman et al., Iowa City, United States. In Future Med Chem, 2013
One such RGS protein is RGS17.
MicroRNA profiling in chemoresistant and chemosensitive acute myeloid leukemia.
Knuutila et al., Helsinki, Finland. In Cytogenet Genome Res, 2012
Genes targeted by miR-363 include RGS17 and HIPK3, both reported to be associated with drug response.
A high throughput screen for RGS proteins using steady state monitoring of free phosphate formation.
Roman et al., Iowa City, United States. In Plos One, 2012
In this study we developed a simple and inexpensive assay for the steady state analysis of RGS protein GAP activity, using RGS4, RGS8 and RGS17 as models.
GPCRs promote the release of zinc ions mediated by nNOS/NO and the redox transducer RGSZ2 protein.
Garzón et al., Madrid, Spain. In Antioxid Redox Signal, 2012
Thus, MOR activation stimulates the complex formed by RGSZ2 (a regulator of G protein signaling) and neural nitric oxide synthase (nNOS) to produce NO, and to recruit PKCγ and Raf-1 in a zinc-dependent manner.
Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence.
Park et al., Seoul, South Korea. In Hum Genet, 2012
Two single nucleotide polymorphisms in the regulator of G-protein signaling 17 gene are associated with smoking initiation.
Interleukin-1β modulates smooth muscle cell phenotype to a distinct inflammatory state relative to PDGF-DD via NF-κB-dependent mechanisms.
Owens et al., Charlottesville, United States. In Physiol Genomics, 2012
Finally, immunofluorescent staining of mouse atherosclerotic lesions revealed the presence of cells positive for the marker of an IL-1β-stimulated inflammatory SMC, chemokine (C-C motif) ligand 20 (CCL20), but not the PDGF-DD-induced gene, regulator of G protein signaling 17 (RGS17).
Protein expression pattern in response to ionizing radiation in MCF-7 human breast cancer cells.
Lee et al., Seoul, South Korea. In Oncol Lett, 2012
One set of proteins (GH2, RGS17, BAK1, CCNH, TSG6, RAD51B, IGFBP1 and CASP14) was upregulated and another set of proteins (C1QRF, PLSCR2 and p34(SE1-1)) was downregulated after exposure to γ-rays.
Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses.
Gelernter et al., New Haven, United States. In Behav Brain Funct, 2011
Variation in RGS17 was associated with risk for substance dependence diagnoses in both African American and European American populations.
Altered expression and function of regulator of G-protein signaling-17 (RGS17) in hepatocellular carcinoma.
McKillop et al., Charlotte, United States. In Cell Signal, 2011
RGS17 is differentially expressed in hepatocellular carcinoma cells and plays a central role in regulating transformed hepatocyte tumorgenicity.
RGSZ2 binds to the neural nitric oxide synthase PDZ domain to regulate mu-opioid receptor-mediated potentiation of the N-methyl-D-aspartate receptor-calmodulin-dependent protein kinase II pathway.
Sánchez-Blázquez et al., Madrid, Spain. In Antioxid Redox Signal, 2011
This RGSZ2-dependent regulation of NMDAR activity is relevant to persistent pain disorders associated with heightened NMDAR-mediated glutamate responses and the reduced antinociceptive capacity of opioids.
SUMO-SIM interactions regulate the activity of RGSZ2 proteins.
Sánchez-Blázquez et al., Madrid, Spain. In Plos One, 2010
SUMO-SIM interactions regulate the activity of RGSZ2 proteins
RGS17/RGSZ2 and the RZ/A family of regulators of G-protein signaling.
Albert et al., London, Canada. In Semin Cell Dev Biol, 2006
The RZ/A family includes RGSZ2/RGS17 (the most recently discovered member of this family), GAIP/RGS19, RGSZ1/RGS20, and the RGSZ1 variant Ret-RGS.
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