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Regulator of G-protein signaling 12

This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: RGS, RGS16, CAN, V1a, GAP
Papers on RGS12
Regulators of G protein signaling 12 promotes osteoclastogenesis in bone remodeling and pathological bone loss.
Yang et al., Buffalo, United States. In Cell Death Differ, Dec 2015
It was previously demonstrated that Rgs12, the largest protein in the Rgs family, is predominantly expressed in OCs and regulates OC differentiation in vitro.
PDZ Protein Regulation of G Protein-Coupled Receptor Trafficking and Signaling Pathways.
Ferguson et al., London, Canada. In Mol Pharmacol, Oct 2015
These PDZ domain-containing proteins include the membrane-associated guanylate-like kinases [postsynaptic density protein of 95 kilodaltons; synapse-associated protein of 97 kilodaltons; postsynaptic density protein of 93 kilodaltons; synapse-associated protein of 102 kilodaltons; discs, large homolog 5; caspase activation and recruitment domain and membrane-associated guanylate-like kinase domain-containing protein 3; membrane protein, palmitoylated 3; calcium/calmodulin-dependent serine protein kinase; membrane-associated guanylate kinase protein (MAGI)-1, MAGI-2, and MAGI-3], Na(+)/H(+) exchanger regulatory factor proteins (NHERFs) (NHERF1, NHERF2, PDZ domain-containing kidney protein 1, and PDZ domain-containing kidney protein 2), Golgi-associated PDZ proteins (Gα-binding protein interacting protein, C-terminus and CFTR-associated ligand), PDZ domain-containing guanine nucleotide exchange factors (GEFs) 1 and 2, regulator of G protein signaling (RGS)-homology-RhoGEFs (PDZ domain-containing RhoGEF and leukemia-associated RhoGEF), RGS3 and RGS12, spinophilin and neurabin-1, SRC homology 3 domain and multiple ankyrin repeat domain (Shank) proteins (Shank1, Shank2, and Shank3), partitioning defective proteins 3 and 6, multiple PDZ protein 1, Tamalin, neuronal nitric oxide synthase, syntrophins, protein interacting with protein kinase C α 1, syntenin-1, and sorting nexin 27.
Variation at FCGR2A and functionally related genes is associated with the response to anti-TNF therapy in rheumatoid arthritis.
Marsal et al., Barcelona, Spain. In Plos One, 2014
DHX32 and RGS12 were the most consistently correlated genes with FCGR2A expression in RA synovial fluid macrophages (P<0.001).
Development of inhibitors of heterotrimeric Gαi subunits.
Peterson et al., Charleston, United States. In Bioorg Med Chem, 2014
Endogenous protein guanine nucleotide dissociation inhibitors (GDIs) like AGS3/4 and RGS12/14 function through GPR/Goloco GDI domains.
Inhibition of Gαi activity by Gβγ is mediated by PI 3-kinase-γ- and cSrc-dependent tyrosine phosphorylation of Gαi and recruitment of RGS12.
Murthy et al., Richmond, United States. In Am J Physiol Gastrointest Liver Physiol, 2014
The Gi2-coupled δ-opioid receptor agonist d-penicillamine (2,5)-enkephalin (DPDPE) activated cSrc, stimulated tyrosine phosphorylation of Gαi2, and induced regulator of G protein signaling 12 (RGS12) association; all three events were blocked by PI 3-kinase (LY294002) and cSrc (PP2) inhibitors and by expression of the COOH-terminal sequence of GRK2-(495-689), a Gβγ-scavenging peptide.
Alveolar bone loss: mechanisms, potential therapeutic targets, and interventions.
Yang et al., Boston, United States. In Adv Dent Res, 2014
RGS12 is a crucial protein that mediates osteoclastogenesis and bone destruction, and a potential therapeutic target.
Exome sequencing in 53 sporadic cases of schizophrenia identifies 18 putative candidate genes.
Antonarakis et al., Genève, Switzerland. In Plos One, 2013
Overall, this study provides a list of 18 putative candidate genes for sporadic SCZ, and when combined with the results of similar reports, identifies a second proband carrying a non-synonymous DNV in the RGS12 gene.
Combined linkage analysis and exome sequencing identifies novel genes for familial goiter.
Koizumi et al., Kyoto, Japan. In J Hum Genet, 2013
In one of the families, we found two rare heterozygous missense variants, p.V56M in RGS12 and p.G37D in GRPEL1, which segregate with goiter and are both located within the same haplotype on 4p16.
Mx1-cre mediated Rgs12 conditional knockout mice exhibit increased bone mass phenotype.
Kim et al., Buffalo, United States. In Genesis, 2013
Rgs12 is the largest protein of the Rgs protein family.
Group II activators of G-protein signaling: monitoring the interaction of Gα with the G-protein regulatory motif in the intact cell.
Lanier et al., Charleston, United States. In Methods Enzymol, 2012
GPR proteins include the Group II Activators of G-protein signaling identified in a functional screen for receptor-independent activators of G-protein signaling (GPSM1-3, RGS12) each of which contain 1-4 GPR motifs.
Genetic variations in the regulator of G-protein signaling genes are associated with survival in late-stage non-small cell lung cancer.
Wu et al., Houston, United States. In Plos One, 2010
Among them, rs2749786 of RGS12 was most significant.
Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation.
Siderovski et al., Chapel Hill, United States. In Embo J, 2007
RGS12 may play a critical, and receptor-selective, role in coordinating Ras-dependent signals that are required for promoting and/or maintaining neuronal differentiation.
RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro.
Li et al., Boston, United States. In J Bone Miner Res, 2007
RGS12 is essential for the terminal differentiation of osteoclasts induced by RANKL.
Differential expression of regulator of G-protein signaling R12 subfamily members during mouse development.
D'Souza et al., London, Canada. In Dev Dyn, 2005
RGS12 splice variants exhibit differential spatiotemporal patterns of expression during postimplantation embryogenesis, suggesting nonoverlapping roles
The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits.
Willard et al., Chapel Hill, United States. In Int J Biol Sci, 2004
These new roles include the RGS-box-containing, RhoA-specific guanine nucleotide exchange factors (RGS-RhoGEFs) that serve as Galpha effectors to couple 7TM and semaphorin receptor signaling to RhoA activation, the potential for RGS12 to serve as a nexus for signaling from tyrosine kinases and G-proteins of both the Galpha and Ras-superfamilies, the potential for R7-subfamily RGS proteins to couple Galpha subunits to 7TM receptors in the absence of conventional Gbetagamma dimers, and the potential for the conjoint 7TM/RGS-box Arabidopsis protein AtRGS1 to serve as a ligand-operated GAP for the plant Galpha AtGPA1.
Physiological actions of regulators of G-protein signaling (RGS) proteins.
Kurachi et al., Suita, Japan. In Life Sci, 2004
For the latter mechanism, additional regulatory modules, such as PDZ, PX, and G-protein gamma subunit-like (GGL) domains, identified in several RGS proteins may be responsible: (i) PDZ domain of RGS12 interacts with a G-protein-coupled chemokine receptor, CXCR2, and thus facilitates its GAP action on CXCR2-mediated G-protein signals.
Return of the GDI: the GoLoco motif in cell division.
Siderovski et al., Chapel Hill, United States. In Annu Rev Biochem, 2003
The GoLoco motif is present as an independent element within multidomain signaling regulators, such as Loco, RGS12, RGS14, and Rap1GAP, as well as in tandem arrays in proteins, such as AGS3, G18, LGN, Pcp-2/L7, and Partner of Inscuteable (Pins/Rapsynoid).
Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel.
Diversé-Pierluissi et al., New York City, United States. In Nature, 2001
Inhibition of endogenous RGS12, a member of the family of regulators of G-protein signalling, selectively alters the time course of voltage-independent inhibition.
Molecular cloning and expression analysis of rat Rgs12 and Rgs14.
Siderovski et al., Toronto, Canada. In Biochem Biophys Res Commun, 1997
shows chromosomal mapping information for human locus.
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