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Regulator of G-protein signaling 10

RGS10, regulator of G-protein signaling 10
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: RGS, RGS4, RGS2, CAN, V1a
Papers on RGS10
Structure of the Regulator of G Protein Signaling 8 (RGS8)-Gαq Complex: Molecular Basis for Gα Selectivity.
Tesmer et al., United States. In J Biol Chem, Feb 2016
Based on the RGS8 structure, residues in RGS8 that contact a unique α-helical domain loop of Gαq were converted to those typically found in R12 subfamily members, and the reverse substitutions were introduced into RGS10, an R12 subfamily member.
Regulator of G-Protein Signaling 10 Negatively Regulates Cardiac Remodeling by Blocking Mitogen-Activated Protein Kinase-Extracellular Signal-Regulated Protein Kinase 1/2 Signaling.
Yuan et al., Changsha, China. In Hypertension, Jan 2016
Regulator of G-protein signaling 10 (RGS10) is an important member of the RGS family and produces biological effects in multiple organs.
Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells.
Murph et al., Athens, United States. In Cancer Lett, Jan 2016
The regulator of G protein signaling 10 (RGS10) protein is a GTPase activating protein that accelerates the hydrolysis of GTP and therefore canonically inactivates G proteins, ultimately terminating signaling.
Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients.
Peng et al., Beijing, China. In Cell Res, Nov 2015
Among these markers, 4 (RGS10, ST8SIA6, RUNX2 and VIM) are mostly specific for cancer detection, while the other 15, classified as a novel set, are already hypermethylated in the normal liver tissues.
The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration.
Chen et al., Winston-Salem, United States. In Neuroscience, Nov 2015
There was a positive correlation of the messenger ribonucleic acid (mRNA) levels of RGS10 between the VTA and the NAc in the control animals, which was abolished by AMPH self-administration.
Cellular deficiency in the RGS10 protein facilitates chemoresistant ovarian cancer.
Murph et al., Athens, United States. In Future Med Chem, Aug 2015
This article will discuss basic RGS molecular pharmacology, summarize the cellular functions and epigenetic regulation of RGS10, review ovarian cancer chemotherapy and describe the role of RGS10 in ovarian cancer survival signaling.
Age-related changes in regulator of G-protein signaling (RGS)-10 expression in peripheral and central immune cells may influence the risk for age-related degeneration.
Tansey et al., Atlanta, United States. In Neurobiol Aging, May 2015
In humans, the regulator of G-protein signaling-10 (RGS10) locus has been associated with age-related maculopathy.
Physiology of RGS10 in Neurons and Immune Cells.
Tansey et al., Atlanta, United States. In Prog Mol Biol Transl Sci, 2014
Regulator of G protein signaling-10 (RGS10), a GTPase-activating protein (GAP) for Gαi3, Gαq, and Gαz, belongs to the D/R12 subfamily based on the homology within the RGS domain and is one of the smallest RGS proteins, outside the RGS box.
Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1).
Brass et al., Philadelphia, United States. In Plos One, 2014
This node is comprised of a scaffold protein (spinophilin, SPL), a protein tyrosine phosphatase (SHP-1), and either of the two members of the Regulators of G protein Signaling family predominantly expressed in platelets (RGS10 or RGS18).
Regulators of G protein signaling are up-regulated in aspirin-resistant platelets from patients with metabolic syndrome.
Huo et al., In Pharmazie, 2014
Although there were no clinical differences between the two groups, transcripts of RGS2, RGS10, and RGS18 were significantly higher in aspirin-resistant patients than in aspirin-sensitive patients.
Alveolar bone loss: mechanisms, potential therapeutic targets, and interventions.
Yang et al., Boston, United States. In Adv Dent Res, 2014
A working model for RGS10 and RGS12 in the regulation of Ca(2+) oscillations during osteoclast differentiation is proposed.
Regulator of G protein signaling transcript expression in human neural progenitor differentiation: R7 subfamily regulation by DNA methylation.
Hooks et al., Athens, United States. In Neurosignals, 2013
Further, we showed that direct pharmacological inhibition of DNMT activity enhances expression of RGS2, RGS4, RGS5, RGS6, RGS7, RGS8, RGS9L, RGS10, and RGS14 as well as R7BP and R9AP transcripts in progenitors, consistent with regulation by DNMTs.
A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling.
Brass et al., Philadelphia, United States. In Blood, 2012
Data show that that SPL/RGS/SHP1 complexes are present in resting platelets where constitutive phosphorylation of SPL(Y398) creates an atypical binding site for SHP-1.
Regulator of G-protein signaling-10 negatively regulates NF-κB in microglia and neuroprotects dopaminergic neurons in hemiparkinsonian rats.
Tansey et al., Atlanta, United States. In J Neurosci, 2011
RGS10 negatively regulates nuclear factor kappaB activation and production pathway in microglia and demonstrates the neuroprotective effects of microglial RGS10 gene transfer in a rat model of parkinsonism.
RGS10 restricts upregulation by chemokines of T cell adhesion mediated by α4β1 and αLβ2 integrins.
Teixidó et al., Madrid, Spain. In J Immunol, 2011
RGS10 is a key molecule that contributes to the inhibition of Galpha-dependent signaling during chemokine-activated alpha4beta1- and alphaLbeta2-dependent T cell adhesion.
Characterization of regulators of G-protein signaling RGS4 and RGS10 proteins in the postmortem human brain.
Javier Meana et al., Leioa, Spain. In Neurochem Int, 2010
RGS10 and RGS4 proteins are both detected in postmortem prefrontal cortex.
Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention.
Goldberg et al., Atlanta, United States. In Neurobiol Dis, 2010
If chronic inflammation can be shown to decrease the levels of neuroprotective factors in the midbrain, in essence genetic haploinsufficiency of protective factors such as Parkin or RGS10 may result from purely environmental triggers (aging, chronic systemic disease, etc.), increasing the vulnerability to inflammation-induced nigral DA neuron death and predisposing an individual to development of PD.
Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells.
Murph et al., Athens, United States. In Mol Cancer, 2009
Results establish RGS10 and RGS17 as novel regulators of cell survival and chemoresistance in ovarian cancer cells and suggest that their reduced expression may be diagnostic of chemoresistance.
Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits.
Ross et al., Dallas, United States. In Science, 1997
The extent of inhibition of Gz GAP, GAIP, RGS4, and RGS10 correlated roughly with their intrinsic GAP activities for the Galpha target used in the assay.
RGS10 is a selective activator of G alpha i GTPase activity.
Peralta et al., Cambridge, United States. In Nature, 1996
Here we report the characterization of human RGS10, a member of this protein family.
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