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Ral guanine nucleotide dissociation stimulator

Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010] (from NCBI)
Top mentioned proteins: fibronectin, CAN, ACID, HAD, CD45
Papers using RGDS antibodies
Critical roles for the COOH-terminal NITY and RGT sequences of the integrin β3 cytoplasmic domain in inside-out and outside-in signaling
Du Xiaoping et al., In The Journal of Cell Biology, 1999
... RGDS peptide was from Bachem, and ristocetin was from ...
Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3.
Zwaka Thomas, In PLoS ONE, 1996
... RGDS and RGES peptides were from Bachem, human purified platelet factor ...
Molecular mechanisms of platelet activation
Siess Wolfgang et al., In Journal of Translational Medicine, 1988
... Arg-Gly-Asp-Ser (RGDS) peptide was from Bachem Biochemica (Heidelberg, Germany) ...
Papers on RGDS
Tuning microenvironment modulus and biochemical composition promotes human mesenchymal stem cell tenogenic differentiation.
Kloxin et al., Newark, United States. In J Biomed Mater Res A, Feb 2016
Monomer concentrations were varied to achieve a range of matrix moduli (E ∼ 10 - 90 kPa), and different ratios of integrin-binding peptides were incorporated (GFOGER and RGDS for collagen and fibronectin, respectively), mimicking aspects of developing tendon/ligament tissue.
Lovastatin induces platelet apoptosis.
Dai et al., Suzhou, China. In Environ Toxicol Pharmacol, Feb 2016
The integrin αIIbβ3 antagonist, RGDS, inhibited lovastatin-induced apoptosis in both human platelets and Chinese hamster ovary (CHO) cells stably expressing integrin αIIbβ3.
Designing Visible Light-Cured Thiol-Acrylate Hydrogels for Studying the HIPPO Pathway Activation in Hepatocellular Carcinoma Cells.
Lin et al., Indianapolis, United States. In Macromol Biosci, Jan 2016
The effects of matrix stiffness and integrin binding motif (e.g., RGDS) on Huh7 cell growth and HIPPO pathway activation are studied using PEG4A-peptide hydrogels.
Inhibition of the interactions between metastatic human breast cancer cells and platelets by β-nitrostyrene derivatives.
Wu et al., Kao-hsiung, Taiwan. In Life Sci, Jan 2016
In contrast to current antiplatelet strategies, the glycoprotein IIb/IIIa (GPIIb/IIIa) antagonist RGDS peptide only prevented cancer cells-induced platelet aggregation, but not platelet adhesion and secretion; whereas the cyclooxygenase inhibitor aspirin and the adenosine diphosphate (ADP) scavenger apyrase affected neither platelet aggregation nor platelet secretion.
Influenza infection induces platelet-endothelial adhesion which contributes to lung injury.
Lee et al., Toronto, Canada. In J Virol, Jan 2016
Instead, platelet adhesion was inhibited both by RGDS peptide and by a blocking antibody to platelet integrin α5β1, implicating endothelial fibronectin.
Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation.
Keskin et al., Frederick, United States. In Expert Rev Proteomics, Dec 2015
Raf, PI3K and RalGDS are major K-Ras effectors.
Approaches to the stabilisation of bioactive epitopes by grafting and peptide cyclisation.
Schroeder et al., Brisbane, Australia. In Biopolymers, Dec 2015
Two such epitopes are LyP1, a nine residue peptide that localises to tumour cells and has potential as an anti-cancer therapeutic and RGDS a tetrapeptide shown to bind to survivin and induce apoptosis.
Oncogenesis and the clinical significance of K-ras in pancreatic adenocarcinoma.
Yang et al., Chongqing, China. In Asian Pac J Cancer Prev, 2012
Activated KRAS engages multiple effector pathways, notably the RAF-mitogen-activated protein kinase, phosphoinositide-3-kinase (PI3K) and RalGDS pathways.
Biomarkers downstream of RAS: a search for robust transcriptional targets.
Schäfer et al., Berlin, Germany. In Curr Cancer Drug Targets, 2010
RAS proteins interact with a number of effector proteins that in turn activate the Raf/MEK/ERK pathway, the PI3K/PKB/Akt pathway, the RalGDS/Ral pathway and other downstream pathways.
RalGDS family members couple Ras to Ral signalling and that's not all.
Trabalzini et al., Siena, Italy. In Cell Signal, 2010
The members of the RalGDS family, RalGDS, RGL, RGL2/Rlf and RGL3, can interact with activated Ras through their Ras Binding Domain (RBD), but may function as effectors for other Ras family members.
Herpesviruses: hijacking the Ras signaling pathway.
Sourvinos et al., Irákleion, Greece. In Biochim Biophys Acta, 2010
Upon activation, Ras proteins employ several downstream effector molecules such as phosphatidylinositol 3-kinase (PI3-K) and Raf and Ral guanine nucleotide-dissociation stimulators (RALGDS) to regulate a cascade of events ranging from cell proliferation and survival to apoptosis and cellular death.
Dissection of RAS downstream pathways in melanomagenesis: a role for Ral in transformation.
Merlino et al., Bethesda, United States. In Oncogene, 2010
constitutive RalGEF activation had a major impact on several malignant phenotypes, particularly anchorage-independent growth, indicating that this often overlooked pathway should be more carefully evaluated as a possible therapeutic target.
Ras classical effectors: new tales from in silico complexes.
Valencia et al., Madrid, Spain. In Trends Biochem Sci, 2009
Studies provide models for Ras in association with Raf kinase, RalGDS and PI3Kalpha and PI3Kgamma.
RalA functions as an indispensable signal mediator for the nutrient-sensing system.
Hanada et al., Tokyo, Japan. In J Biol Chem, 2009
RalGDS and RalA act downstream of Rheb and that RalA activation is a crucial step in nutrient-induced mTORC1 activation
Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells.
Voorberg et al., Amsterdam, Netherlands. In Blood, 2008
overexpression of RalGDS promotes exocytosis of Weibel-Palade bodies from endothelial cells
The merlin interacting proteins reveal multiple targets for NF2 therapy.
Scoles, Los Angeles, United States. In Biochim Biophys Acta, 2008
In efforts to determine merlin function several groups have discovered 34 merlin interacting proteins, including ezrin, radixin, moesin, CD44, layilin, paxillin, actin, N-WASP, betaII-spectrin, microtubules, TRBP, eIF3c, PIKE, NHERF, MAP, RalGDS, RhoGDI, EG1/magicin, HEI10, HRS, syntenin, caspr/paranodin, DCC, NGB, CRM1/exportin, SCHIP1, MYPT-1-PP1delta, RIbeta, PKA, PAK (three types), calpain and Drosophila expanded.
No evidence of RALGDS mutations in cutaneous melanoma.
Hansson et al., Stockholm, Sweden. In Melanoma Res, 2007
results of screening suggest that RALGDS is not mutationally altered in cutaneous melanoma
RalGDS is required for tumor formation in a model of skin carcinogenesis.
Marshall et al., London, United Kingdom. In Cancer Cell, 2005
Results identify RalGDS as a key component in Ras-dependent carcinogenesis in vivo.
RalGDS comes of age.
McCormick et al., San Francisco, United States. In Cancer Cell, 2005
RalGDS is such a candidate: in a new paper from Chris Marshall's group, an important role for RalGDS in Ras transformation in vivo has been established for the first time.
Competition for related but nonidentical binding sites on the glycoprotein IIb-IIIa complex by peptides derived from platelet adhesive proteins.
Lawing et al., In Cell, 1987
Two distinct sequences of amino acids, RGDS and HHLGGAKQAGDV, each inhibit the binding of fibrinogen, fibronectin, and von Willebrand factor to the platelet membrane glycoprotein IIb-IIIa complex.
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