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Regulatory factor X, 2

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: RFX, Histone, OUT, CHIP, HAD
Papers on RFX2
RFX2 Is a Major Transcriptional Regulator of Spermiogenesis.
Reith et al., Lyon, France. In Plos Genet, Jul 2015
Here we report that the RFX2 transcription factor is a master regulator of genes required for the haploid phase.
TGF-β Signaling Regulates the Differentiation of Motile Cilia.
Kato et al., Stuttgart, Germany. In Cell Rep, Jun 2015
Interestingly, this TGF-β activity is not mediated by Mcidas, Foxj1, and RFX2, the known major regulators of ciliogenesis.
Schizophrenia gene expression profile reverted to normal levels by antipsychotics.
Sainz et al., Santander, Spain. In Int J Neuropsychopharmacol, Feb 2015
Six genes (ADAMTS2, CD177, CNTNAP3, ENTPD2, RFX2, and UNC45B) out of the 17 are among the 200 genes that we characterized with differential expression in a previous study between antipsychotic-naïve schizophrenia patients and controls (Sainz et al., 2013).
Whole-exome sequencing points to considerable genetic heterogeneity of cerebral palsy.
MacLennan et al., Adelaide, Australia. In Mol Psychiatry, Feb 2015
Ten de novo mutations in three previously identified disease genes (TUBA1A (n=2), SCN8A (n=1) and KDM5C (n=1)) and in six novel candidate CP genes (AGAP1, JHDM1D, MAST1, NAA35, RFX2 and WIPI2) were predicted to be potentially pathogenic for CP.
Genome-wide transcript profiling reveals novel breast cancer-associated intronic sense RNAs.
John et al., Pittsburgh, United States. In Plos One, 2014
Sixteen genomic loci were identified that map to the long introns of five key protein-coding genes, CRIM1, EPAS1, ZEB2, RBMS1, and RFX2.
Coordinated genomic control of ciliogenesis and cell movement by RFX2.
Wallingford et al., Austin, United States. In Elife, 2013
Starting from genomic analysis of the cilia-associated transcription factor Rfx2, we used bioinformatics and in vivo cell biological approaches to gain insights into the molecular basis of cilia assembly and function.
The mood stabilizer valproate activates human FGF1 gene promoter through inhibiting HDAC and GSK-3 activities.
Chiu et al., Taiwan. In J Neurochem, 2013
In this study, we provide several lines of evidence to demonstrate the underlying mechanisms of VPA in activating FGF-1B promoter activity: (i) VPA significantly increased the FGF-1B mRNA expression and the percentage of F1BGFP(+) cells; (ii) the increase of F1BGFP expression by VPA involves changes of regulatory factor X (RFX) 1-3 transcriptional complexes and the increase of histone H3 acetylation on the 18-bp cis-element of FGF-1B promoter; (iii) treatments of other histone deacetylases (HDAC) inhibitors, sodium butyrate and trichostatin A, significantly increased the expression levels of FGF-1B, RFX2, and RFX3 transcripts; (iv) treatments of glycogen synthase kinase 3 (GSK-3) inhibitor, lithium, or GSK-3 siRNAs also significantly activated FGF-1B promoter; (v) VPA specifically enhanced neuronal differentiation in F1BGFP(+) embryonic stem cells and NSPCs rather than GFP(-) cells.
Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy.
Dolan et al., Chicago, United States. In Clin Cancer Res, 2013
One of these eQTLs is located in RFX2, which encodes a member of the DNA-binding regulatory factor X family.
Effect of cigarette smoking on human oviductal ciliation and ciliogenesis.
Burney et al., Tacoma, United States. In Fertil Steril, 2013
Expression of ciliogenic transcription factors FOXJ1, RFX2, and RFX3 was consistent between groups.
Ciliogenic RFX transcription factors regulate FGF1 gene promoter.
Chiu et al., Taiwan. In J Cell Biochem, 2012
Taken together, this study suggests ciliogenic RFX transcription factors regulate FGF-1B promoter activity and the maintenance of F1BGFP(+) NSPCs and GBM-SCs.
RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow.
Brueckner et al., United States. In Dev Biol, 2012
Data show that that Rfx2 is expressed in motile cilia in mouse and zebrafish embryos.
RFX2 is broadly required for ciliogenesis during vertebrate development.
Wallingford et al., Austin, United States. In Dev Biol, 2012
Bioinformatic analysis suggests that Rfx2 is among the closest homologues of Daf19.
Transcriptional regulation of the Alström syndrome gene ALMS1 by members of the RFX family and Sp1.
Wilson et al., Southampton, United Kingdom. In Gene, 2010
We show binding of RFX proteins to an evolutionarily conserved X-box in the ALMS1 proximal promoter and present evidence that these proteins are responsible for ALMS1 transcription during growth arrest
Differential expression of Rfx1-4 during mouse spermatogenesis.
Kistler et al., Columbia, United States. In Gene Expr Patterns, 2009
RFX2 may play roles in haploid cells during mouse spermatogenesis
FGF signalling during embryo development regulates cilia length in diverse epithelia.
Yost et al., Salt Lake City, United States. In Nature, 2009
Abrogation of Fgfr1 signalling downregulates expression of two ciliogenic transcription factors, foxj1 and rfx2, and of the intraflagellar transport gene ift88 (also known as polaris), indicating that FGF signalling mediates cilia length through an Fgf8/Fgf24-Fgfr1-intraflagellar transport pathway.
RFX2 is a candidate downstream amplifier of A-MYB regulation in mouse spermatogenesis.
Kistler et al., Columbia, United States. In Bmc Dev Biol, 2008
RFX2 is potentially an important transcriptional regulator in pachytene spermatocytes; Rfx2 itself is a good candidate to be regulated by A-MYB, which is essential for meiotic progression.
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