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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Angiotensin II, HAD, AGE, CAN, ARB
Papers on Renin
Renin-angiotensin-aldosterone system blockers for heart failure with reduced ejection fraction or left ventricular dysfunction: Network meta-analysis.
Yan et al., Beijing, China. In Int J Cardiol, Mar 2016
BACKGROUND: Renin-angiotensin-aldosterone system (RAAS) blockers are effective therapies for heart failure and reduced ejection fraction (HFrEF) or left ventricular dysfunction (LVD).
Angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers and the risk of major adverse cardiac events in patients with diabetes and prior stroke: a nationwide study.
Chen et al., Taipei, Taiwan. In J Hypertens, Jan 2016
OBJECTIVE: Renin-angiotensin-aldosterone system blockers are the preferred antihypertensive medications in patients with diabetes and prior stroke.
Propranolol versus captopril in the treatment of infantile hemangioma (IH): A randomized controlled trial.
Mohy et al., Cairo, Egypt. In J Am Acad Dermatol, Jan 2016
BACKGROUND: Renin-angiotensin system components have been demonstrated in the biology of infantile hemangioma (IH).
Atrial fibrillation in heart failure: what should we do?
Piccini et al., Durham, United States. In Eur Heart J, Jan 2016
We propose an easy-to-use clinical mnemonic to aid the initial management of newly discovered concomitant HF and AF, the CAN-TREAT HFrEF + AF algorithm (Cardioversion if compromised; Anticoagulation unless contraindication; Normalize fluid balance; Target initial heart rate <110 b.p.m.; Renin-angiotensin-aldosterone modification; Early consideration of rhythm control; Advanced HF therapies; Treatment of other CV disease).
Fixed-Dose Combinations of Renin-Angiotensin System Inhibitors and Calcium Channel Blockers in the Treatment of Hypertension: A Comparison of Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors.
Chu et al., Taipei, Taiwan. In Medicine (baltimore), Dec 2015
Fixed-dose combinations (FDCs) of different regimens are recommended in guidelines for the treatment of hypertension.
Resveratrol improves vasoprotective effects of captopril on aortic remodeling and fibrosis triggered by renovascular hypertension.
Restini et al., Ribeirão Preto, Brazil. In Cardiovasc Pathol, Dec 2015
BACKGROUND: Renin-angiotensin system triggers vascular remodeling and fibrosis during the renovascular hypertensive two-kidney, one-clip (2K1C) model by oxidative-stress-mediated mechanisms.
[Adrenal incidentaloma].
Gabalec et al., In Vnitr Lek, Oct 2015
Aldosterone and Renin should be measured only in patients with hypertension and catecholamines in tumours with higher native density than 10 HU.
Can Targeting the Incretin Pathway Dampen RAGE-Mediated Events In Diabetic Nephropathy?
Coughlan et al., Melbourne, Australia. In Curr Drug Targets, Aug 2015
To date, interruption of the Renin-Angiotensin System is the most effective intervention for diabetic nephropathy, however these agents only slow progression of the disease.
ACE and ACE2 in kidney disease.
Ohashi et al., Hiroshima, Japan. In World J Nephrol, Mar 2015
Renin angiotensin system (RAS) activation has a significant influence on renal disease progression.
Hypertension and valsartan.
Üresin et al., İstanbul, Turkey. In Anadolu Kardiyol Derg, 2014
Renin-angiotensin system (RAS) plays an important role in pathophysiology and in turn treatment of the disease.
Human prorenin structure sheds light on a novel mechanism of its autoinhibition and on its non-proteolytic activation by the (pro)renin receptor.
Böcskei et al., Strasbourg, France. In J Mol Biol, 2012
X-ray structure of a prorenin sheds light on a novel mechanism of its autoinhibition and on its non-proteolytic activation by the (pro)renin receptor
Inhibitory activities of baicalin against renin and angiotensin-converting enzyme.
Yuan et al., Chongqing, China. In Pharm Biol, 2012
The inhibition activity of baicalin against renin was a result of the formation of stable complex through multisites binding including the active site.
Gene expression profiling reveals renin mRNA overexpression in human hypertensive kidneys and a role for microRNAs.
Morris et al., Sydney, Australia. In Hypertension, 2011
Hsa-miR-663 can bind to the REN 3' untranslated regions and can regulate REN mRNA levels, whereas hsa-miR-181a regulated REN mRNA.
Effect of direct renin inhibitor, aliskiren, on peripheral blood monocyte subsets and myocardial salvage in patients with primary acute myocardial infarction.
Akasaka et al., Wakayama, Japan. In Circ J, 2011
A direct renin inhibitor combined with an ACEI or an ARB can better improve the extent of myocardial salvage after acute myocardial infarction.
Two-site automated chemiluminescent assay for measurement of immunoreactive renin.
Persu et al., Brussels, Belgium. In Biomarkers, 2011
Results demonstrate that the Liaison((R)) direct renin assay may assist the clinician in the assessment of hypertensive patients and in the screening for primary aldosteronism.
Plasma prorenin activity and complications in children with insulin-dependent diabetes mellitus.
Luetscher et al., Stanford, United States. In N Engl J Med, 1990
BACKGROUND: Renin, secreted into the blood by the juxtaglomerular cells of the kidneys, is derived from a larger precursor, prorenin.
Mechanism of renal hypertension.
Trust et al., In Lancet, 1976
Renin and angiotensin are probably not involved at this stage.
SMEBY et al., In Science, 1965
Bioassays for renin activity have shown that these granular cells can synthesize considerable amounts of renin in vitro.
PAGE et al., In Science, 1964
Administration of rat renin to uninephrectomized rats reproduced most, if not all, the changes (hypertension, vascular disease, hypertrophy of the zona glomerulosa of the adrenals) found after partial constriction of the renal artery.
PAGE et al., In Science, 1963
Small reductions in renal perfusion pressure to levels still within a physiologic range, which did not reduce renal blood flow, caused the kidney to release renin.
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