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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

V-rel reticuloendotheliosis viral oncogene homolog

Rel, c-Rel
The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor (MIM 164008) (Belguise and Sonenshein, 2007 [PubMed 18037997]).[supplied by OMIM, May 2008] (from NCBI)
Top mentioned proteins: NF-kappaB, p65, CAN, V1a, RelB
Papers using Rel antibodies
Gene discovery in rheumatoid arthritis highlights the CD40/NF-kappaB signaling pathway in disease pathogenesis.
Ko Ben C.B., In PLoS ONE, 2009
... c-Fos, Fos B, Fra-1, Fra-2, c-Jun, Jun B, Jun D, NFAT2 (NFATc1, clone 7A2), p65/RelA, c-Rel, p50 (NLS), and IκBs -α, -β and -ε, used for immunoblots, EMSA supershift and immunoprecipitation, were all from Santa Cruz Biotechnology (Insight Biotechnology, Wembley, UK) ...
IL-8 as antibody therapeutic target in inflammatory diseases: reduction of clinical activity in palmoplantar pustulosis.
Chodosh James et al., In Molecular Vision, 2007
... Antibodies to p38, IKKα/β, NFκB p65, NFκB p50, IκB, cREL, and their phosphorylated counterparts were obtained from Cell Signaling Technology (Beverly, MA) and ...
Mitochondrial membrane permeabilization in cell death.
Blanke Steven R., In PLoS Pathogens, 2006
... Cover; e) mouse monoclonal anti-LAMP1, from BD Biosciences (San Jose, CA); f) rabbit polyclonal anti-p65-Rel, from Santa Cruz Biotechnology (Santa Cruz, CA); g) ...
Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of noxa
Miyamoto Shigeki et al., In Molecular Cancer, 2005
... (06–886) and p52/p100 (06–413) antibodies were purchased from Upstate Biotechnologies (Lake Placid, NY), and the cRel (SA-172) antibody was purchased from Biomol (Plymouth Meeting, PA) ...
Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate
Hoffmann Alexander et al., In Molecular Systems Biology, 1997
... RelA/p65 (sc-372), RelB (sc-226), cRel (sc-71), IκBα (sc-371), IκBβ (sc-946), and IκBɛ (sc-7156) antibodies were from Santa Cruz Biotechnology.
Papers on Rel
Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB-Controlled Oxidative Stress Responses.
Zakrzewski et al., New York City, United States. In Cancer Res, Feb 2016
Here, we describe IT-901, a bioactive naphthalenethiobarbiturate derivative that potently inhibits the NF-κB subunit c-Rel.
c-Rel and its many roles in cancer: an old story with new twists.
Perkins et al., Newcastle upon Tyne, United Kingdom. In Br J Cancer, Feb 2016
When the genes encoding NF-κB subunits were first isolated, their homology to the previously identified c-Rel proto-oncogene and its viral homologue v-Rel was clear.
Human T-cell leukemia virus type 1 (HTLV-1) Tax1 oncoprotein but not HTLV-2 Tax2 induces the expression of OX40 ligand by interacting with p52/p100 and RelB.
Fujii et al., Niigata, Japan. In Virus Genes, Feb 2016
In addition, Tax1 but not Tax2 or Tax1/225-232 interacted with p65, p50, and c-Rel; however, the interactions were much less than those noted with NF-κB2/p100/p52 and RelB.
Identification and characterization of an apoptosis-stimulating protein of p53 (ASPP) gene from Branchiostoma belcheri: Insights into evolution of ASPP gene family.
Ma et al., Qingdao, China. In Fish Shellfish Immunol, Jan 2016
Finally, bioinformatic analyses displayed that amphioxus ASPP protein could interact with REL protein by conserved binding sites compared with human ASPP2 protein, which seemed to further suggest that the amphioxus ASPP protein involve in innate immunity through NF-кB signaling pathway.
Genetic Variation in the REL Gene Increases Risk of Behcet's Disease in a Chinese Han Population but That of PRKCQ Does Not.
Hou et al., Chongqing, China. In Plos One, Dec 2015
The REL rs842647 polymorphism may be a susceptibility factor for BD pathogenesis and skin lesions, which indicate that c-Rel may be involved in the pathogenesis and skin lesions of BD through the NF-κB pathway.
Radiation Inhibits Interleukin-12 Production via Inhibition of C-Rel through the Interleukin-6/ Signal Transducer and Activator of Transcription 3 Signaling Pathway in Dendritic Cells.
Seong et al., Seoul, South Korea. In Plos One, Dec 2015
IL-6 and signal transducer and activator of transcription 3 (STAT3) inhibitors restored the irradiation-induced IL-12 decrease via suppression of C-Rel activation.
NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis.
Pasparakis et al., Köln, Germany. In Cancer Cell, Dec 2015
Here, we show that complete NF-κB inhibition by combined LPC-specific ablation of RelA, c-Rel, and RelB did not phenocopy NEMO deficiency, but constitutively active IKK2-mediated NF-κB activation prevented hepatocellular damage and HCC in NEMO(LPC-KO) mice.
The immunogenetics of Psoriasis: A comprehensive review.
Bowcock et al., New York City, United States. In J Autoimmun, Nov 2015
These genes span an array of functions that involve antigen presentation (HLA-Cw6, ERAP1, ERAP2, MICA), the IL-23 axis (IL12Bp40, IL23Ap19, IL23R, JAK2, TYK2), T-cell development and T-cells polarization (RUNX1, RUNX3, STAT3, TAGAP, IL4, IL13), innate immunity (CARD14, c-REL, TRAF3IP2, DDX58, IFIH1), and negative regulators of immune responses (TNIP1, TNFAIP3, NFKBIA, ZC3H12C, IL36RN, SOCS1).
Unexpected functions of nuclear factor-κB during germinal center B-cell development: implications for lymphomagenesis.
Heise et al., New York City, United States. In Curr Opin Hematol, Jul 2015
Most notably, a single NF-κB subunit, c-REL, was found to be required for the maintenance of the germinal center reaction and was associated with the activation of a metabolic program that promotes cell growth.
NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review.
Yang et al., Taipei, Taiwan. In Front Mol Neurosci, 2014
The RelA and c-Rel expression produce opposite effects on neuronal survival.
NF-κB in Innate Neuroprotection and Age-Related Neurodegenerative Diseases.
Pizzi et al., Brescia, Italy. In Front Neurol, 2014
In stroke models, the activation of NF-κB/c-Rel promotes neuroprotective effects by transcription of specific anti-apoptotic genes.
Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.
Heissmeyer et al., München, Germany. In Nat Immunol, 2014
Roquin inhibited T(H)17 cell differentiation and acted together with the endoribonuclease regnase-1 to repress target mRNA encoding the T(H)17 cell-promoting factors IL-6, ICOS, c-Rel, IRF4, IκBNS and IκBζ.
PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan.
Jasper et al., Novato, United States. In Cell, 2014
Here, we show that, in the aging intestine of Drosophila, chronic activation of the transcription factor Foxo reduces expression of peptidoglycan recognition protein SC2 (PGRP-SC2), a negative regulator of IMD/Relish innate immune signaling, and homolog of the anti-inflammatory molecules PGLYRP1-4.
Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation.
Akira et al., Suita, Japan. In Cell, 2013
Moreover, in T cells, Regnase-1 regulates the mRNAs of a set of genes, including c-Rel, Ox40, and Il2, through cleavage of their 3' UTRs.
Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation.
Lin et al., Chicago, United States. In Cell, 2013
TNFα-treated Ikkβ(-/-) mouse embryonic fibroblasts (MEFs) undergo apoptosis significantly faster than MEFs deficient in both RelA and cRel due to lack of inhibition of BAD by IKK.
Genome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL.
Franke et al., Kiel, Germany. In J Invest Dermatol, 2012
c-Rel, as a member of the Rel/NF-kappaB family, is associated with psoriatic arthritis.
Alternative pathway of cell death in Drosophila mediated by NF-κB transcription factor Relish.
Dolph et al., United States. In Proc Natl Acad Sci U S A, 2012
NF-kappaB transcription factor Relish mediates the alternative pathway of cell death in Drosophila
Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1.
Moynagh et al., Ireland. In J Biol Chem, 2012
Nuclear factor kappaB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated beta-interferon production via induction of transcriptional repressor protein YY1.
Insect neuropeptide bursicon homodimers induce innate immune and stress genes during molting by activating the NF-κB transcription factor Relish.
Song et al., Columbia, United States. In Plos One, 2011
induction of antimicrobial peptide expression is via activation of the NF-kappaB transcription factor Relish in the immune deficiency (Imd) pathway
c-Rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells.
Gerondakis et al., Melbourne, Australia. In Plos One, 2010
These results support a model of natural Foxp3(+) CD4 regulatory T cells (nTreg) differentiation in which c-Rel generates a permissive state for foxp3 transcription during the development of nTreg precursors.
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