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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


Regucalcin, SMP30, RGN, Senescence marker protein-30
binds calcium ions; induces increased activity of the sarcoplasmic reticulum calcium-transporting ATPase [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, AGE, CAN, HAD, OUT
Papers on Regucalcin
Selection-free gene repair after adenoviral vector transduction of designer nucleases: rescue of dystrophin synthesis in DMD muscle cell populations.
Gonçalves et al., Leiden, Netherlands. In Nucleic Acids Res, Feb 2016
The strategies tested involved; incorporating small insertions or deletions at out-of-frame sequences for reading frame resetting, splice acceptor knockout for DNA-level exon skipping, and RGN-RGN or RGN-TALEN multiplexing for targeted exon(s) removal.
Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome.
Mussolino et al., Freiburg, Germany. In Mol Ther, Jan 2016
RGN specificity depends on both the guide RNA (gRNA) and the protospacer adjacent motif (PAM) recognized by the Cas9 protein.
Aging-associated changes in oxidative stress, cell proliferation, and apoptosis are prevented in the prostate of transgenic rats overexpressing regucalcin.
Socorro et al., Covilhã, Portugal. In Transl Res, Dec 2015
Regucalcin (RGN) is a calcium (Ca(2+))-binding protein that displays a characteristic downregulated expression with aging in several tissues.
Suppressed glycolytic metabolism in the prostate of transgenic rats overexpressing calcium-binding protein regucalcin underpins reduced cell proliferation.
Socorro et al., Covilhã, Portugal. In Transgenic Res, Dec 2015
UNASSIGNED: Regucalcin (RGN) is a calcium-binding protein underexpressed in human prostate cancer cases, and it has been associated with the suppression of cell proliferation and the regulation of several metabolic pathways.
Effect of extracellular calcium on regucalcin expression and cell viability in neoplastic and non-neoplastic human prostate cells.
Maia et al., Covilhã, Portugal. In Biochim Biophys Acta, Oct 2015
Regucalcin (RGN), a Ca2+-binding protein that plays a relevant role in intracellular Ca2+ homeostasis, was identified as an under-expressed protein in human PCa.
5α-Dihydrotestosterone regulates the expression of L-type calcium channels and calcium-binding protein regucalcin in human breast cancer cells with suppression of cell growth.
Socorro et al., Covilhã, Portugal. In Med Oncol, Sep 2015
On the other hand, regucalcin (RGN) is a Ca(2+)-binding protein involved in the control of mammary gland cell proliferation, which has been identified as an androgen target gene in distinct tissues except breast.
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases.
Joung et al., United States. In Nat Biotechnol, Feb 2015
Application of GUIDE-seq to 13 RGNs in two human cell lines revealed wide variability in RGN off-target activities and unappreciated characteristics of off-target sequences.
Stem Cell Replacement Improves Expression of SMP30 in db/db Mice.
Ikehara et al., Hirakata, Japan. In Int J Mol Sci, 2014
Senescence marker protein 30 (SMP30) is an antioxidant protein that decreases with aging.
Expressions of Senescence-Associated β-Galactosidase and Senescence Marker Protein-30 are Associated with Lens Epithelial Cell Apoptosis.
Hao et al., Harbin, China. In Med Sci Monit, 2014
BACKGROUND To investigate associations of senescence marker protein-30 and senescence-associated β-galactosidase expression with lens epithelial cells apoptosis among Chinese age-related cataract patients.
Potential biomarkers associated with diabetic glomerulopathy through proteomics.
Lin et al., Taiwan. In Ren Fail, 2014
However, diabetic glomeruli in rats had significantly lower levels of the Regucalcin, rCG52140, Aldo-keto reductase family 1, Peroxiredoxin 1, and l-arginine: glycine amidinotransferase.
The diverse roles of calcium-binding protein regucalcin in cell biology: from tissue expression and signalling to disease.
Socorro et al., Covilhã, Portugal. In Cell Mol Life Sci, 2014
Regucalcin (RGN) is a calcium (Ca(2+))-binding protein widely expressed in vertebrate and invertebrate species, which is also known as senescence marker protein 30, due to its molecular weight (33 kDa) and a characteristically diminished expression with the aging process.
Role of regucalcin in cell nuclear regulation: involvement as a transcription factor.
Yamaguchi, Atlanta, United States. In Cell Tissue Res, 2013
Regucalcin (RGN/SMP30) was discovered in 1978 as a calcium (Ca(2+))-binding protein that contains no EF-hand motif of the Ca(2+)-binding domain.
The anti-apoptotic effect of regucalcin is mediated through multisignaling pathways.
Yamaguchi, Atlanta, United States. In Apoptosis, 2013
Regucalcin (RGN/SMP30) was originally discovered in 1978 as a calcium-binding protein that does not contain the EF-hand motif of as a calcium-binding domain.
A review on ochratoxin A transcriptomic studies.
López de Cerain et al., Pamplona, Spain. In Food Chem Toxicol, 2013
Regucalcin was highly downregulated in vivo and other calcium homeostasis genes were significantly deregulated in vitro.
Suppressive role of regucalcin in liver cell proliferation: involvement in carcinogenesis.
Yamaguchi, Atlanta, United States. In Cell Prolif, 2013
Regucalcin (RGN/SMP30) was discovered in 1978 and is a unique calcium-binding protein contains no EF-hand motif calcium-binding domain.
Ascorbic acid deficiency leads to epidermal atrophy and UVB-induced skin pigmentation in SMP30/GNL knockout hairless mice.
Ishigami et al., In J Invest Dermatol, 2012
Ascorbic acid deficiency leads to epidermal atrophy and UVB-induced skin pigmentation in SMP30/GNL knockout hairless mice
Regucalcin, a calcium-binding protein with a role in male reproduction?
Socorro et al., Covilhã, Portugal. In Mol Hum Reprod, 2012
RGN has a role in spermatogenesis, directly or as a mediator of androgen action. [review]
Regucalcin is broadly expressed in male reproductive tissues and is a new androgen-target gene in mammalian testis.
Socorro et al., Covilhã, Portugal. In Reproduction, 2011
Rgn is a novel androgen-target gene in testis and may have a role in male reproductive function, particularly in the control of spermatogenesis.
Regucalcin (RGN/SMP30) alters agonist- and thapsigargin-induced cytosolic [Ca2+] transients in cells by increasing SERCA Ca(2+)ATPase levels.
Michelangeli et al., Birmingham, United Kingdom. In Febs Lett, 2011
Data show that regucalcin (RGN) reduces agonist (histamine)-induced Ca(2+) transients in RGN(+) transfected COS-7 cells (RGN(+)) and also increases their Ca(2+) storage capacity.
Regucalcin and cell regulation: role as a suppressor protein in signal transduction.
Yamaguchi, Atlanta, United States. In Mol Cell Biochem, 2011
Studies indicate that regucalcin plays an important role as a regulatory protein in cell signaling system, and it is proposed to play a pivotal role in keep of cell homeostasis and function.
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