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Phosphatidylinositol transfer protein, membrane-associated 1

rdgB, Nir2, RD9, RdgB1
PITPNM1 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 [PubMed 15627748]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, V1a, Nir, OUT
Papers on rdgB
In vivo tracking of phosphoinositides in Drosophila photoreceptors.
Sengupta et al., Cambridge, United Kingdom. In J Cell Sci, Jan 2016
Resynthesis of PtdIns4P (t½ ∼12 s) was faster than PtdIns(4,5)P2 (t½ ∼40 s), but both were greatly slowed in mutants of DAG kinase (rdgA) or PtdIns transfer protein (rdgB).
Multidrug resistant Mycobacterium tuberculosis of the Latin American Mediteranean lineage wrongly identified as Mycobacterium pinnipedii (ST863) causing active tuberculosis in south Brazil.
Suffys et al., Porto Alegre, Brazil. In J Clin Microbiol, Oct 2015
Because this species is rarely encountered in humans, we further characterized these nine isolates by additional genotyping techniques, including 24 MIRU-VNTR typing, verification of TbD1, RD9, pks15/1, RD(Rio), fbpC (AG85), the insertion of IS6110 at a site specific for the M. tuberculosis Latin American Mediterranean (LAM) lineage and whole genome sequencing.
High level of IFN-γ released from whole blood of human tuberculosis infections following stimulation with Rv2073c of Mycobacterium tuberculosis.
Fan et al., Wuhan, China. In J Microbiol Methods, Jul 2015
The region of difference 9 (RD9) presents the genome of the causative pathogen Mycobacterium tuberculosis rather than other species of the genus Mycobacterium, which might be promising targets for specific diagnosis, vaccine development and pathogenesis.
Phosphatidylinositol-Phosphatidic Acid Exchange by Nir2 at ER-PM Contact Sites Maintains Phosphoinositide Signaling Competence.
Balla et al., Bethesda, United States. In Dev Cell, Jul 2015
Here, we show that the Drosophila RdgB homolog, Nir2, a presumed PtdIns transfer protein, not only transfers PtdIns from the ER to the PM but also transfers PtdOH to the opposite direction at ER-PM contact sites.
Molecular typing and drug sensitivity testing of Mycobacterium tuberculosis isolated by a community-based survey in Ethiopia.
Lemma et al., Addis Ababa, Ethiopia. In Bmc Public Health, 2014
RESULT: All 92 isolates were confirmed as M. tuberculosis by RD9-based PCR and spoligotyping of 91 of these isolates leds to the identification of 41 spoligotype patterns.
Prevalence and drug resistance profile of Mycobacterium tuberculosis isolated from pulmonary tuberculosis patients attending two public hospitals in East Gojjam zone, northwest Ethiopia.
Aseffa et al., Portugal. In Bmc Public Health, 2014
METHODS: A cross-sectional study was conducted between May 2011 and January 2012 using Region of difference-9 (RD9) typing for the identification of species mycobacterium.
Active tuberculosis case finding and detection of drug resistance among HIV-infected patients: A cross-sectional study in a TB endemic area, Gondar, Northwest Ethiopia.
Aseffa et al., Gonder, Ethiopia. In Int J Mycobacteriol, 2014
A PCR-based RD9 deletion and genus typing, as well as first-line anti-TB drug susceptibility testing, was performed for all culture-positive isolates.
Potential role for phosphatidylinositol transfer protein (PITP) family in lipid transfer during phospholipase C signalling.
Garner et al., London, United Kingdom. In Adv Biol Regul, 2013
In the mammalian genome, there are three genes that code for soluble PITP proteins, PITPα, PITPβ and RdgBβ and two genes that code for membrane-associated multi-domain proteins (RdgBαI and II) containing a PITP domain.
Indocyanine green-polyethylene glycol-folate
Leung, Bethesda, United States. In Unknown Journal, 2011
One of the NIR dyes (NIR2) was conjugated to amino-derivatized folic acid to form NIR2-folate, which has an excitation maximum at 665 nm and an emission maximum at 686 nm.
RdgB proteins: functions in lipid homeostasis and signal transduction.
Padinjat et al., Cambridge, United Kingdom. In Biochim Biophys Acta, 2007
The founding member of the family DrdgB alpha (Drosophila rdgB) appears to be essential for sensory transduction and maintenance of ultra structure in photoreceptors (retinal sensory neurons).
Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase.
Cunningham et al., Albany, United States. In J Biol Chem, 2007
RdgB homologs play a preemptive role in excluding endogenous and exogenous modified purine deoxyribonucleoside triphosphates (dTNPs) from incorporation into DNA.
Phospholipid transfer proteins in perspective.
Wirtz, Utrecht, Netherlands. In Febs Lett, 2006
Dm RdgB, Nir2, Nir3) and in peroxisomal beta-oxidation enzyme-related SCP-2 (i.e.
Leung, Bethesda, United States. In Unknown Journal, 2006
One of the NIR dyes (NIR2) was conjugated to amino-derivatized folic acid to form NIR2-folate, which has an excitation maximum at 665 nm and an emission maximum at 686 nm.
Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function.
Lev et al., Israel. In Nat Cell Biol, 2005
Nir2 is involved in maintaining a critical DAG pool in the Golgi apparatus by regulating its consumption via the CDP-choline pathway
Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion.
Lev et al., Israel. In Mol Cell, 2004
Phosphorylation of Nir2 by Cdk1 facilitates its dissociation from the Golgi apparatus, and phospho-Nir2 is localized in the cleavage furrow and midbody during cytokinesis.
Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-transfer domain.
Lev et al., Israel. In Curr Biol, 2002
A specific Thr residue in the Nir2 PI-transfer domain provides a regulatory site for targeting to lipid droplets. This may affect intracellular lipid trafficking & distribution & explain the dominant effect of the RdgB-T59E mutant on retinal degeneration.
Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis.
Lev et al., Israel. In Mol Cell Biol, 2002
Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis.
Photoreceptor deactivation and retinal degeneration mediated by a photoreceptor-specific protein kinase C.
Zuker et al., San Diego, United States. In Science, 1992
In flies carrying the retinal degeneration mutation rdgB, absence of eye-PKC suppressed photoreceptor cell degeneration.
Ectopic expression of a minor Drosophila opsin in the major photoreceptor cell class: distinguishing the role of primary receptor and cellular context.
Rubin et al., Berkeley, United States. In Cell, 1988
In addition, we show that two mutants that specifically affect the R1-R6 cells, ninaA and rdgB, do not directly affect expression of the ninaE gene.
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