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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Nucleoredoxin-like 1

RdCVF, Rod-derived Cone Viability Factor, thioredoxin-like 6, Nxnl1
Top mentioned proteins: ROD, Thioredoxin, CAN, NF-kappaB, AGE
Papers on RdCVF
Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners.
Muramatsu, Nagoya, Japan. In J Biochem, Jan 2016
Basigin has isoforms; the common form (basigin or basigin-2) has 2 immunoglobulin domains, and the extended form (basigin-1) has 3. Basigin is the receptor for cyclophilins, S100A9, and platelet GPVI, while basigin-1 serves as the receptor for the rod-derived cone viability factor.
Rods Feed Cones to Keep them Alive.
Roska et al., Basel, Switzerland. In Cell, Jun 2015
Aït-Ali et al. describe a molecular mechanism by which RdCVF, a factor normally released by rods, controls glucose entry into cones, enhancing their survival.
Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis.
Léveillard et al., Paris, France. In Cell, Jun 2015
Rod-derived cone viability factor (RdCVF) is an inactive thioredoxin secreted by rod photoreceptors that protects cones from degeneration.
Thioredoxin rod-derived cone viability factor protects against photooxidative retinal damage.
Léveillard et al., Paris, France. In Free Radic Biol Med, Apr 2015
Rod-derived cone viability factor (RdCVF) is a trophic factor of the thioredoxins family that promotes the survival of cone photoreceptors.
Gene therapy for the eye focus on mutation-independent approaches.
Sahel et al., Paris, France. In Curr Opin Neurol, Feb 2015
To extend gene therapy's promise to a large number of patients, evidence suggests retina-specific trophic factors, such as rod-derived cone viability factor, can be used to slow down loss of cone cells responsible for our high acuity vision.
Transcriptional regulation of nucleoredoxin-like genes takes place on a daily basis in the retina and pineal gland of rats.
Spessert et al., Mainz, Germany. In Vis Neurosci, 2015
The nucleoredoxin-like gene Nxnl1 (Txnl6) and its paralogue Nxnl2 encode the rod-derived cone viability factors (RdCVF and RdCVF2), which increase the resistance to photooxidative damage and have therapeutic potential for the survival of cones in retinitis pigmentosa.
Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration.
Flannery et al., In J Clin Invest, 2015
Alternative splicing of nucleoredoxin-like 1 (Nxnl1) results in 2 isoforms of the rod-derived cone viability factor.
Therapeutic strategy for handling inherited retinal degenerations in a gene-independent manner using rod-derived cone viability factors.
Sahel et al., Paris, France. In C R Biol, 2014
We have identified the bifunctional genes nucleoredoxin-like 1 and 2 that encode for, by differential splicing, a thioredoxin enzyme and a cone survival factor, respectively RdCVF and RdCVF2.
Optimal control in the treatment of retinitis pigmentosa.
Wirkus et al., Phoenix, United States. In Bull Math Biol, 2014
The recent discovery of the RdCVF protein has provided researchers with a potential therapy that could slow the secondary wave of cone death.
Nxnl2 splicing results in dual functions in neuronal cell survival and maintenance of cell integrity.
Léveillard et al., Paris, France. In Hum Mol Genet, 2012
The rod-derived cone viability factors, RdCVF and RdCVF2, have potential therapeutical interests for the treatment of inherited photoreceptor degenerations.
℮-conome: an automated tissue counting platform of cone photoreceptors for rodent models of retinitis pigmentosa.
Léveillard et al., Paris, France. In Bmc Ophthalmol, 2010
Rod-derived Cone Viability Factor is a thioredoxin-like protein that is secreted by rods and is involved in cone survival.
The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress.
Léveillard et al., Paris, France. In Cell Death Differ, 2010
The RdCVF gene has an essential role in photoreceptor maintenance and resistance to retinal oxidative stress.
The homeobox gene CHX10/VSX2 regulates RdCVF promoter activity in the inner retina.
Léveillard et al., Paris, France. In Hum Mol Genet, 2010
CHX10 regulates RdCVF promoter activity in the inner retina.
Expression of rod-derived cone viability factor: dual role of CRX in regulating promoter activity and cell-type specificity.
Zack et al., Paris, France. In Plos One, 2009
regulation of the Nucleoredoxin-like genes involves a CRX responsive element that can act as both as a positive regulator of promoter activity and as a modulator of cell-type specificity
TXNL6 is a novel oxidative stress-induced reducing system for methionine sulfoxide reductase a repair of α-crystallin and cytochrome C in the eye lens.
Kantorow et al., Boca Raton, United States. In Plos One, 2009
Data suggest a critical role for TXNL6 in MsrA repair of essential lens proteins under oxidative stress conditions and that TXNL6 is important for MsrA defense protection against cataract.
The thioredoxin-like protein rod-derived cone viability factor (RdCVFL) interacts with TAU and inhibits its phosphorylation in the retina.
Léveillard et al., Paris, France. In Mol Cell Proteomics, 2009
functional interaction between RdCVFL and TAU described here is the first characterization of the RdCVFL signaling pathway involved in neuronal cell death mediated by oxidative stress
[Neuroprotection of photoreceptor cells in rod-cone dystrophies: from cell therapy to cell signalling].
Léveillard et al., Paris, France. In C R Biol, 2005
Our group has (1) established and confirmed the existence of non cell autonomous mechanisms promoting cone cell viability; (2) shown that rod cell protection or replacement provides a mean to extend the survival of cones; (3) demonstrated that rod-cone trophic interactions are mediated by diffusible proteins; (4) identified by expression cloning a protein mediating such interactions: RdCVF (Rod-derived Cone Viability Factor).
Identification and characterization of rod-derived cone viability factor.
Sahel et al., Paris, France. In Nat Genet, 2004
is a truncated thioredoxin-like protein specifically expressed by photoreceptors. The identification of this protein offers new treatment possibilities for retinitis pigmentosa
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