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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Retinol binding protein 2, cellular

RBP2, cellular retinol-binding protein II, retinoblastoma binding protein 2
RBP2 is an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. RBP2 may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, demethylase, CAN, ACID, CRBP
Papers on RBP2
Characterization of a linked Jumonji domain of the KDM5/JARID1 family of histone H3 lysine 4 demethylases.
Cheng et al., United States. In J Biol Chem, Jan 2016
Accumulating evidence from primary tumors and model systems support a role for KDM5A (JARID1A/RBP2) and KDM5B (JARID1B/PLU1) as oncogenic drivers.
siRNA targeting RBP2 inhibits expression, proliferation, tumorigenicity and invasion in thyroid carcinoma cells.
Cui et al., Jining, China. In Oncol Lett, Dec 2015
UNASSIGNED: In order to estimate the effects of small interfering RNA (siRNA) targeting retinoblastoma binding protein 2 (RBP2) on the proliferation, expression, invasion, migration and tumorigenicity abilities of papillary thyroid carcinoma K1 cells, siRNA targeting RBP2 (RBP2-siRNA) and negative control siRNA were transfected into K1 cells.
Retinoblastoma-binding protein 2 induces epithelial-mesenchymal transition in esophageal squamous cancer cells.
Hu et al., Jinan, China. In Biotechnol Lett, Dec 2015
OBJECTIVES: To investigate the effect of retinoblastoma-binding protein 2 (RBP2) on epithelial-mesenchymal transition (EMT) in esophageal squamous cancer cells and to compare the effect of RBP2 in lung squamous cancer cells and esophageal squamous cancer cells.
The rpb2 gene represents a viable alternative molecular marker for the analysis of environmental fungal communities.
Baldrian et al., Praha, Czech Republic. In Mol Ecol Resour, Sep 2015
The fungal taxon spectra obtained with rbp2 region and ITS1 corresponded, but sequence abundance differed widely, especially in the basal lineages.
Histone demethylase RBP2 promotes malignant progression of gastric cancer through TGF-β1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit.
Jia et al., Jinan, China. In Oncotarget, Aug 2015
Here, we demonstrated that the histone demethylase RBP2 was crucial for TGF-β1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit that was implicated in malignant progression of tumors and its knockdown significantly inhibited gastric cancer (GC) metastasis both in vitro and in vivo.
Altered Splicing of JARID1B in Development of Human Cutaneous Melanoma?
Chwirot et al., Gliwice, Poland. In Appl Immunohistochem Mol Morphol, Apr 2015
Our data indicate that parallel immunohistochemical assays of the expression levels of all the isoforms and of the RBP2-H1 variant of JARID1B may be an efficient technique of differentiating between benign naevi and melanomas.
Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters the intestinal vitamin A status in rats.
Yoshino et al., Akita, Japan. In Int J Mol Med, Mar 2015
In the present study, we used a rat model of SB syndrome in order to assess its effects on the expression of genes associated with the absorption, transport and metabolism of vitamin A. In the rats with SB, the intestinal mRNA expression levels of cellular retinol-binding protein II (CRBP II, gene symbol Rbp2) and apolipoprotein A-IV (gene symbol Apoa4) were higher than those in the sham-operated rats, as shown by RT-qPCR.
Characterization of Plasmodium ovale curtisi and P. ovale wallikeri in Western Kenya utilizing a novel species-specific real-time PCR assay.
Stewart et al., Bethesda, United States. In Plos Negl Trop Dis, 2015
METHODS: In order to detect all P. ovale subspecies simultaneously, we developed an inclusive P. ovale-specific real-time PCR assay based on conserved regions between P. ovale curtisi and P. ovale wallikeri in the reticulocyte binding protein 2 (rbp2) gene.
H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence.
Lowe et al., United States. In Proc Natl Acad Sci U S A, 2012
Jarid1a/b-mediated H3K4 demethylation contributes to silencing of retinoblastoma target genes in senescent cells, suggesting a mechanism by which retinoblastoma triggers gene silencing.
Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.
Panda et al., Los Angeles, United States. In Science, 2011
JARID1a formed a complex with CLOCK-BMAL1 which was recruited to Per2 promoter;it increased histone acetylation by inhibiting histone deacetylase 1 function and enhanced transcription by CLOCK-BMAL1; JARID1a depletion shortened period of circadian rhythms
The histone demethylase JARID1A is associated with susceptibility to ankylosing spondylitis.
Wordsworth et al., Oxford, United Kingdom. In Genes Immun, 2011
JARID1A or a locus in strong linkage disequilibrium with it is a positional candidate for susceptibility to AS.
Binding affinities of CRBPI and CRBPII for 9-cis-retinoids.
Napoli et al., Berkeley, United States. In Biochim Biophys Acta, 2011
Data show that CRBPI and CRBPII bind 9-cis-retinol and 9-cis-retinal with high affinities, albeit with affinities somewhat lower than for all-trans-retinol and all-trans-retinal.
Drug-tolerant cancer cells show reduced tumor-initiating capacity: depletion of CD44 cells and evidence for epigenetic mechanisms.
Tang et al., United States. In Plos One, 2010
Evidence was provided that chronic drug exposure generated drug-tolerant cells via epigenetic mechanisms involving molecules such as CD44 and KDM5A.
Genetic and epigenetic alteration in gastric carcinogenesis.
Machado et al., Porto, Portugal. In Helicobacter, 2010
Several genes have been newly associated with gastric carcinogenesis, both through oncogenic activation (MYC, SEMA5A, BCL2L12, RBP2 and BUBR1) and tumor suppressor gene inactivation mechanisms (KLF6, RELN, PTCH1A, CLDN11, and SFRP5).
A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth.
Herlyn et al., Philadelphia, United States. In Cell, 2010
Using the H3K4 demethylase JARID1B (KDM5B/PLU-1/RBP2-H1) as a biomarker, we have characterized a small subpopulation of slow-cycling melanoma cells that cycle with doubling times of >4 weeks within the rapidly proliferating main population.
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations.
Settleman et al., United States. In Cell, 2010
These cells demonstrate >100-fold reduced drug sensitivity and maintain viability via engagement of IGF-1 receptor signaling and an altered chromatin state that requires the histone demethylase RBP2/KDM5A/Jarid1A.
RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.
Helin et al., Copenhagen, Denmark. In Cell, 2007
Study shows that RBP2 is displaced from Hox genes during embryonic stem cell differentiation correlating with an increase of their di- and trimethylated histone 3 lysine 4 levels and expression.
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.
Shi et al., Boston, United States. In Cell, 2007
Other SMCX family members, including SMCY, RBP2, and PLU-1, also demethylated H3K4me3.
The retinoblastoma binding protein RBP2 is an H3K4 demethylase.
Kaelin et al., Chapel Hill, United States. In Cell, 2007
Study reports that RBP2 is a demethylase that specifically catalyzes demethylation on histone H3 lysine 4, whose methylation is normally associated with transcriptionally active genes.
Extra-and intracellular transport of retinoids: a reappraisal.
Siegenthaler, Switzerland. In Horm Res, 1995
Recently, it was reported that, in addition to the native RBP, two truncated forms of RBP, RBP1 and RBP2, are also present in normal serum.
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