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RNA binding motif, single stranded interacting protein

RBMS3, RNA-binding protein RBMS3
This gene encodes an RNA-binding protein that belongs to the c-myc gene single-strand binding protein family. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. The encoded protein was isolated by virtue of its binding to an upstream element of the alpha2(I) collagen promoter. The observation that this protein localizes mostly in the cytoplasm suggests that it may be involved in a cytoplasmic function such as controlling RNA metabolism, rather than transcription. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010] (from NCBI)
Top mentioned proteins: HAD, c-Myc, TSG, cardiotrophin-1, MAPT
Papers on RBMS3
Head injury, potential interaction with genes, and risk for Parkinson's disease.
Chen et al., United States. In Parkinsonism Relat Disord, Mar 2015
Exploratory interaction analyses showed a significant interaction between head injury and a SNP at the RBMS3 locus (rs10510622, uncorrected P = 0.0001).
RBMS3 is a tumor suppressor gene that acts as a favorable prognostic marker in lung squamous cell carcinoma.
Tong et al., Harbin, China. In Med Oncol, Feb 2015
Recent research indicates that RBMS3 may act as a tumor suppressor gene (TSG) in nasopharyngeal carcinoma (NPC) and esophageal squamous cell carcinoma (ESCC).
Polymorphisms in C-reactive protein and Glypican-5 are associated with lung cancer risk and Gartrokine-1 influences Cisplatin-based chemotherapy response in a Chinese Han population.
Chen et al., Xi'an, China. In Dis Markers, 2014
We selected seven genes (CRP, GPC5, ACTA2, AGPHD1, SEC14L5, RBMS3, and GKN1) that previously reported link to lung cancer (LC) and genotyped single nucleotide polymorphisms (SNPs) of these genes in a case-control study.
Upregulated MiR-1269 in hepatocellular carcinoma and its clinical significance.
Chen et al., Nanning, China. In Int J Clin Exp Med, 2014
There were 9 targeted genes which had been shown concurrently by at least 4 databases: AGAP1, AGK, BPTF, C16orf74, DACT1, LIX1L, RBMS3, ZNF706 and BMPER.
Genetic mapping with multiple levels of phenotypic information reveals determinants of lymphocyte glucocorticoid sensitivity.
Di Rienzo et al., Chicago, United States. In Am J Hum Genet, 2013
Using allelic-imbalance assays, we show that this QTL is a glucocorticoid-dependent cis-regulatory polymorphism for RBMS3, which encodes an RNA-binding protein known as a tumor suppressor.
Gene-gene interaction between RBMS3 and ZNF516 influences bone mineral density.
Deng et al., Xi'an, China. In J Bone Miner Res, 2013
Combining results from these two samples, we found one interacting gene pair (RBMS3 versus ZNF516) which, even after Bonferroni correction for multiple testing, showed consistently significant effects on hip BMD.
Rbms3, an RNA-binding protein, mediates the expression of Ptf1a by binding to its 3'UTR during mouse pancreas development.
Chiang et al., T'ai-chung-shih, Taiwan. In Dna Cell Biol, 2012
binding of Rbms3 to the 3'UTR of Ptf1a regulates the production of the Ptf1a protein
Tumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma.
Guan et al., Hong Kong, Hong Kong. In Ai Zheng, 2012
In recent years, our research group and others have focused on the identification and characterization of novel target TSGs at 3p, such as RASSF1A, BLU, RBMS3, and CHL1, in the development and progression of NPC.
RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis.
Guan et al., Hong Kong, Hong Kong. In Plos One, 2011
A putative TSG RBMS3 (RNA binding motif, single stranded interacting protein 3), located at 3p24-p23, has been identified in our previous study.
Genomewide pharmacogenetics of bisphosphonate-induced osteonecrosis of the jaw: the role of RBMS3.
Zavras et al., New York City, United States. In Oncologist, 2011
genetic susceptibility plays a role in the pathophysiology of Bisphosphonate-related osteonecrosis of the jaw (BRONJ), with RBMS3 having a significant effect in the risk.
Downregulation of RBMS3 is associated with poor prognosis in esophageal squamous cell carcinoma.
Guan et al., Guangzhou, China. In Cancer Res, 2011
a tumor suppression function for the human RBMS3 gene in esophageal squamous cell carcinoma, acting through c-Myc downregulation, with genetic loss of this gene contributing to poor outcomes in disease
Single-nucleotide polymorphism-mass array reveals commonly deleted regions at 3p22 and 3p14.2 associate with poor clinical outcome in esophageal squamous cell carcinoma.
Guan et al., Zhengzhou, China. In Int J Cancer, 2008
Absent and down-regulated expression of several candidate TSGs, including CHL1, PCAF, RBMS3, PLCD1 and CACNA2D3, were detected in primary ESCC tumors and ESCC cell lines.
High-resolution array copy number analyses for detection of deletion, gain, amplification and copy-neutral LOH in primary neuroblastoma tumors: four cases of homozygous deletions of the CDKN2A gene.
Martinsson et al., Göteborg, Sweden. In Bmc Genomics, 2007
Two regions with homozygous deletions, four cases with CDKN2A deletions in 9p and one case with deletion on 3p (the gene RBMS3) were also detected in the tumors.
RNA-binding protein RBMS3 is expressed in activated hepatic stellate cells and liver fibrosis and increases expression of transcription factor Prx1.
Stefanovic et al., Tallahassee, United States. In J Mol Biol, 2007
These results suggest that RBMS3, by binding Prx1 mRNA in a sequence-specific manner, controls Prx1 expression and indirectly collagen synthesis.
Cloning of a human gene closely related to the genes coding for the c-myc single-strand binding proteins.
Tanaka et al., New York City, United States. In Gene, 2000
Southwestern screening of human fibroblast cDNAs with an upstream element of the alpha2(I) collagen promoter (Box 5A) has led to the identification of a novel gene product (RBMS3).
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