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RNA binding motif

RBM3, RNA-binding motif protein 3
This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: iMpact, ACID, bcl-2, HAD, CAN
Papers using RBM3 antibodies
In vitro analysis of microRNA processing using recombinant Dicer and cytoplasmic extracts of HeLa cells.
Gerber André Paul, In PLoS ONE, 2006
... at a ratio of 20 nM siRNA per 25 µl RNAiMax to knockdown RBM3, or pcDNA3.1-RBM3 to overexpress the protein using Lipofectamine reagents (Life Technologies); cells were harvested after ...
Papers on RBM3
Loss of RNA-binding motif protein 3 expression is associated with right-sided localization and poor prognosis in colorectal cancer.
Marx et al., Hamburg, Germany. In Histopathology, Jan 2016
AIMS: RNA-binding motif protein 3 (RBM3) has recently been suggested as a prognostic biomarker in an array of human cancers.
Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress.
Wellmann et al., Basel, Switzerland. In Faseb J, Nov 2015
UNASSIGNED: The cold-inducible RNA-binding motif protein 3 (RBM3) is involved in the protection of neurons in hypoxic-ischemic and neurodegenerative disorders.
Cold stress protein RBM3 responds to temperature change in an ultra-sensitive manner in young neurons.
Kochanek et al., Pittsburgh, United States. In Neuroscience, Nov 2015
Here we show that cold stress protein RNA binding motif 3 (RBM3) increases in neuron and astrocyte cultures maintained at 33 °C or 36 °C for 24 or 48 h, compared to 37 °C controls.
RNA binding protein RBM3 increases β-catenin signaling to increase stem cell characteristics in colorectal cancer cells.
Anant et al., Kansas City, United States. In Mol Carcinog, Oct 2015
Here, we investigated the role of the RNA binding protein RBM3 in stem cell homeostasis in colorectal cancers.
Preliminary Transcriptome Analysis in Lymphoblasts from Cluster Headache and Bipolar Disorder Patients Implicates Dysregulation of Circadian and Serotonergic Genes.
Del Zompo et al., Cagliari, Italy. In J Mol Neurosci, Jul 2015
RNA binding motif protein 3 (RBM3) was the most significantly altered gene in the list (3.17 × 10(-13) in BD, 9.44 × 10(-14) in CH).
RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration.
Mallucci et al., Leicester, United Kingdom. In Nature, Mar 2015
Cooling and hibernation also induce a number of cold-shock proteins in the brain, including the RNA binding protein, RBM3 (ref.
Molecular characterization of RNA binding motif protein 3 (RBM3) gene from Pashmina goat.
Ganai et al., India. In Res Vet Sci, Feb 2015
As an attempt to understand its adaptive genetics, and the role of RNA-binding proteins at the cellular response, this study was conducted to characterize the RBM3 gene in Pashmina goat and its expression during hypothermia.
Tricistronic hepatitis C virus subgenomic replicon expressing double transgenes.
Sun et al., Shijiazhuang, China. In World J Gastroenterol, 2015
METHODS: The alternative 22-nucleotide IRES, RNA-binding motif protein 3 IRES (Rbm3 IRES), was used to form a tricistronic HCV replicon, to facilitate constructing HCV-harboring stable cell lines and successive antiviral screening using a luciferase marker.
Comparative efficacies of six different media for cryopreservation of immature buffalo (Bubalus bubalis) calf testis.
Goel et al., In Reprod Fertil Dev, 2015
High expression of superoxide dismutase2 (SOD2), cold-inducible RNA-binding protein (CIRBP) and RNA-binding motif protein3 (RBM3) proteins in cryopreserved tissues indicated involvement of cell signalling pathways regulating cellular protective mechanisms.
The prognostic factors and multiple biomarkers in young patients with colorectal cancer.
Sun et al., Chengdu, China. In Sci Rep, 2014
P = 0.010), RBM3 (HR = 0.093, 95% CI = 0.012-0.712,
Evaluation of RNA-binding motif protein 3 expression in urothelial carcinoma of the bladder: an immunohistochemical study.
Brimo et al., Montréal, Canada. In World J Surg Oncol, 2014
BACKGROUND: RNA-binding motif protein 3 (RBM3), involved in cell survival, has paradoxically been linked to both oncogenesis as well as an increased survival in several cancers, including urothelial carcinoma (UCA).
In Vitro and In Vivo Modulation of Alternative Splicing by the Biguanide Metformin.
Baghdoyan et al., France. In Mol Ther Nucleic Acids, 2014
The mechanism of action involves AMPK activation and downregulation of the RBM3 RNA-binding protein.
Low RBM3 protein expression correlates with clinical stage, prognostic classification and increased risk of treatment failure in testicular non-seminomatous germ cell cancer.
Jerkeman et al., Lund, Sweden. In Plos One, 2014
BACKGROUND: Expression of the RNA-binding motif protein 3 (RBM3) has been shown to correlate with favourable clinicopathological parameters and prognosis in several cancer diseases.
High expression of RNA-binding motif protein 3 in esophageal and gastric adenocarcinoma correlates with intestinal metaplasia-associated tumours and independently predicts a reduced risk of recurrence and death.
Jirström et al., Lund, Sweden. In Biomark Res, 2013
BACKGROUND: High nuclear expression of the RNA-binding motif protein 3 (RBM3) has previously been found to correlate with favourable clinicopathological characteristics and a prolonged survival in several cancer forms.
High nuclear RBM3 expression is associated with an improved prognosis in colorectal cancer.
Uhlen et al., Stockholm, Sweden. In Proteomics Clin Appl, 2011
high tumor-specific nuclear expression of RBM3 is an independent predictor of good prognosis in colorectal cancer
Enhanced survival of skeletal muscle myoblasts in response to overexpression of cold shock protein RBM3.
Dupont-Versteegden et al., Lexington, United States. In Am J Physiol Cell Physiol, 2011
Overexpression of RBM3 in skeletal muscle myoblasts is associated with an increase in cell survival through inhibitory actions on both apoptosis and necrosis.
Generation of mice deficient in RNA-binding motif protein 3 (RBM3) and characterization of its role in innate immune responses and cell growth.
Taniguchi et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2011
Rbm3(-/-) mouse embryonic fibroblasts have markedly increased number of G2-phase cells, suggesting a hitherto unknown role of RBM3 in the G2-phase control.
Low RBM3 protein expression correlates with tumour progression and poor prognosis in malignant melanoma: an analysis of 215 cases from the Malmö Diet and Cancer Study.
Jirström et al., Lund, Sweden. In J Transl Med, 2010
RBM3 is down-regulated in metastatic melanoma and high nuclear RBM3 expression in the primary tumour is an independent marker of a prolonged overal survival.
High RBM3 expression in prostate cancer independently predicts a reduced risk of biochemical recurrence and disease progression.
Jirström et al., Lund, Sweden. In Diagn Pathol, 2010
high nuclear expression of RBM3 in prostate cancer is associated with a prolonged time to disease progression
A new generation of proto-oncogenes: cold-inducible RNA binding proteins.
Lleonart, Barcelona, Spain. In Biochim Biophys Acta, 2010
This review focuses on the roles of two major cold-inducible RNA binding proteins known in human cells: CIRP and RBM3.
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