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Retinoblastoma binding protein 4

RbAp48, RBBP4
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: Histone, RbAp46, CAN, CYP3A4, H4
Papers on RbAp48
RbAp48 is essential for viability of vertebrate cells and plays a role in chromosome stability.
Takami et al., Miyazaki, Japan. In Chromosome Res, Jan 2016
In order to examine the biological role of pRbAp48 in chicken DT40 cells, we generated a tetracycline-inducible system for conditional RbAp48-knockout cells.
Retinoblastoma-binding Protein 4-regulated Classical Nuclear Transport Is Involved in Cellular Senescence.
Yoneda et al., Sapporo, Japan. In J Biol Chem, Jan 2016
Here, we demonstrated that retinoblastoma-binding protein 4 (RBBP4) functions as a novel regulatory factor to increase the efficiency of importin α/β-mediated nuclear import.
[Effect of RbAp48 knockdown on migration and invasion of human cervical cancer cell line MS751 in vitro].
Rao et al., Guangzhou, China. In Nan Fang Yi Ke Da Xue Xue Bao, Nov 2015
OBJECTIVE: To investigate the effect of RbAp48 knockdown on the migration and invasion of human cervical cancer cells and explore the mechanism.
Computational genomic analysis of PARK7 interactome reveals high BBS1 gene expression as a prognostic factor favoring survival in malignant pleural mesothelioma.
Zarogiannis et al., Lárisa, Greece. In Am J Physiol Lung Cell Mol Physiol, Nov 2015
In the Gordon Mesothelioma Study, 34 of them were assessed out of which SUMO1, UBC3, KIAA0101, HDAC2, DAXX, RBBP4, BBS1, NONO, RBBP7, HTRA2, and STUB1 were significantly overexpressed whereas TRAF6 and MTA2 were significantly underexpressed in MPM patients (network 2).
The proteomic investigation reveals interaction of mdig protein with the machinery of DNA double-strand break repair.
Chen et al., Detroit, United States. In Oncotarget, Oct 2015
In addition to the mdig protein, several DNA repair or chromatin binding proteins, including XRCC5, XRCC6, RBBP4, CBX8, PRMT5, and TDRD, were identified in the complexes by the proteomics analyses using both Orbitrap Fusion and Orbitrap XL nanoESI-MS/MS in four independent experiments.
Identification of novel target genes specifically activated by deregulated E2F in human normal fibroblasts.
Ohtani et al., Sanda, Japan. In Genes Cells, Sep 2015
The analysis identified nine novel targets (BIM, RASSF1, PPP1R13B, JMY, MOAP1, RBM38, ABTB1, RBBP4 and RBBP7), many of which are involved in the p53 and RB tumor suppressor pathways.
The role of the chromatin assembly complex (CAF-1) and its p60 subunit (CHAF1b) in homeostasis and disease.
Crispino et al., Chicago, United States. In Biochim Biophys Acta, Aug 2015
Whereas the diverse functions of the large (CAF-1-p150, CHAF1a) and small (RbAp48, p48) subunits of the CAF-1 complex have been well-characterized in many tissues and extend beyond histone chaperone activity, the contributions of the medium subunit (CAF-1-p60, CHAF1b) are much less well understood.
Towards elucidating the stability, dynamics and architecture of the nucleosome remodeling and deacetylase complex by using quantitative interaction proteomics.
Vermeulen et al., Nijmegen, Netherlands. In Febs J, May 2015
Interestingly, the RBBP4 and RBBP7 proteins are sensitive to high nonionic detergent concentrations during affinity purification.
RbAp48 Is Critical for the Proliferation of Hypopharyngeal Carcinoma.
Wang et al., Jinan, China. In Orl J Otorhinolaryngol Relat Spec, 2014
BACKGROUND: Emerging evidence has indicated the significance of RbAp48 in tumorigenesis.
[Rbb4l enhances TGF-β/Nodal signaling and promotes zebrafish embryonic dorsolization].
Jia et al., Beijing, China. In Yi Chuan, 2013
Human RBBP4 (Retinoblastoma binding protein 4), the homolog of zebrafish Rbb4l, has been shown to form complexes with other chromatin modifiers, but its roles in embryonic development remain unknown.
The biological function of the WD40 repeat-containing protein p55/Caf1 in Drosophila.
Xi et al., Beijing, China. In Dev Dyn, 2012
these studies suggest that p55 is not crucial for PRC2-mediated gene silencing in vivo, and the vital function of p55 is probably not dependent on its interaction with histone H4.
Retinoblastoma-binding proteins 4 and 9 are important for human pluripotent stem cell maintenance.
Eaves et al., Vancouver, Canada. In Exp Hematol, 2011
Data identified RBBP4 and RBBP9 as required for maintenance of multiple PS cell types, and both RBBPs were bound to RB in PS cells.
Chromatin-modifying complex component Nurf55/p55 associates with histones H3 and H4 and polycomb repressive complex 2 subunit Su(z)12 through partially overlapping binding sites.
Müller et al., Heidelberg, Germany. In J Biol Chem, 2011
Chromatin-modifying complex component Nurf55/p55 associates with histones H3 and H4 and polycomb repressive complex 2 subunit Su(z)12 through partially overlapping binding sites.
The enhancer of trithorax and polycomb gene Caf1/p55 is essential for cell survival and patterning in Drosophila development.
Mardon et al., Houston, United States. In Development, 2011
analysis of Caf1 mutant tissue suggests that Caf1 plays important roles in cell survival and segment identity, and loss of Caf1 is associated with a reduction in the Polycomb Repressive Complex 2 (PRC2)-specific histone methylation mark H3K27me3
Insights into association of the NuRD complex with FOG-1 from the crystal structure of an RbAp48·FOG-1 complex.
Mackay et al., Cambridge, United Kingdom. In J Biol Chem, 2011
The FOG-1 peptide contacts a negatively charged binding pocket on top of the RbAp48 beta-propeller that is distinct from the binding surface used by RpAp48 to contact histone H4
Immunotherapeutic targets in estrogen deficiency-dependent Sjögren's syndrome-related manifestations.
Hayashi et al., Tokushima, Japan. In Immunotherapy, 2010
Studies indicate that estrogen deficiency initiates tissue-specific apoptosis in the exocrine gland cells through RbAp48 overexpression.
Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres.
Yanagida et al., Kyoto, Japan. In Cell, 2004
In contrast, Mis15, Mis16 (strong similarity with human RbAp48 and RbAp46), Mis17, and Mis18 are all part of the CENP-A recruitment pathway.
Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes.
Dufau et al., Bethesda, United States. In J Steroid Biochem Mol Biol, 2003
A multiprotein complex is recruited to the hLHR promoter via interaction with Sp1/Sp3: HDACs dock directly to Sp1-1 bound DNA and indirectly to Sp3-1 bound DNA through RbAp48, while mSin3A interacts HDACs and potentiates HDAC1-mediated repression.
lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.
Horvitz et al., Cambridge, United States. In Cell, 1999
lin-53 encodes a protein similar to RbAp48, a mammalian protein that binds Rb.
A retinoblastoma-binding protein related to a negative regulator of Ras in yeast.
Lee et al., San Antonio, United States. In Nature, 1993
Here we report the isolation of a full-length complementary DNA (RbAp48) encoding p48.
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