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Retinoblastoma binding protein 7

RbAp46, Rbbp7, retinoblastoma binding protein 7
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] (from NCBI)
Top mentioned proteins: Histone, RbAp48, CYP3A4, HDAC2, CAN
Papers on RbAp46
RbAp48 is essential for viability of vertebrate cells and plays a role in chromosome stability.
Takami et al., Miyazaki, Japan. In Chromosome Res, Jan 2016
UNASSIGNED: RbAp46/48, histone chaperone, is a family of evolutionarily conserved WD40 repeat-containing proteins, which are involved in various chromatin-metabolizing processes, but their in vivo functional relevance is yet unclear.
Liver X Receptor Agonist Modifies the DNA Methylation Profile of Synapse and Neurogenesis-Related Genes in the Triple Transgenic Mouse Model of Alzheimer's Disease.
Arboleda et al., Bogotá, Colombia. In J Mol Neurosci, Dec 2015
Importantly, changes in methylation status were mainly from synapse-related genes (SYP, SYN1, and DLG3) and neurogenesis-associated genes (HMGB3 and RBBP7).
Computational genomic analysis of PARK7 interactome reveals high BBS1 gene expression as a prognostic factor favoring survival in malignant pleural mesothelioma.
Zarogiannis et al., Lárisa, Greece. In Am J Physiol Lung Cell Mol Physiol, Nov 2015
In the Gordon Mesothelioma Study, 34 of them were assessed out of which SUMO1, UBC3, KIAA0101, HDAC2, DAXX, RBBP4, BBS1, NONO, RBBP7, HTRA2, and STUB1 were significantly overexpressed whereas TRAF6 and MTA2 were significantly underexpressed in MPM patients (network 2).
Identification of novel target genes specifically activated by deregulated E2F in human normal fibroblasts.
Ohtani et al., Sanda, Japan. In Genes Cells, Sep 2015
The analysis identified nine novel targets (BIM, RASSF1, PPP1R13B, JMY, MOAP1, RBM38, ABTB1, RBBP4 and RBBP7), many of which are involved in the p53 and RB tumor suppressor pathways.
NKX6.1 functions as a metastatic suppressor through epigenetic regulation of the epithelial-mesenchymal transition.
Lin et al., Taipei, Taiwan. In Oncogene, Sep 2015
NKX6.1 directly enhances the mRNA level of E-cadherin by recruiting BAF155 coactivator and represses that of vimentin and N-cadherin by recruiting RBBP7 (retinoblastoma binding protein 7) corepressor.
Structure and function insights into the NuRD chromatin remodeling complex.
Klaholz et al., Illkirch-Graffenstaden, France. In Cell Mol Life Sci, Jul 2015
NuRD is a 1 MDa multi-subunit protein complex which comprises many different subunits, among which histone deacetylases HDAC1/2, ATP-dependent remodeling enzymes CHD3/4, histone chaperones RbAp46/48, CpG-binding proteins MBD2/3, the GATAD2a (p66α) and/or GATAD2b (p66β) and specific DNA-binding proteins MTA1/2/3.
Rbbp7 Is Required for Uterine Stromal Decidualization in Mice.
Huo et al., Nanjing, China. In Biol Reprod, Jul 2015
Retinoblastoma binding protein 7 (Rbbp7) is a protein reported as a core component of many histone modification and chromatin remodeling complexes.
An HDAC2-TET1 switch at distinct chromatin regions significantly promotes the maturation of pre-iPS to iPS cells.
Kang et al., Shanghai, China. In Nucleic Acids Res, Jul 2015
We also found that HDAC2 competed with TET1 in the binding of the RbAp46 protein at the promoters of maturation genes and knockdown of TET1 markedly prevented the activation of these genes.
Towards elucidating the stability, dynamics and architecture of the nucleosome remodeling and deacetylase complex by using quantitative interaction proteomics.
Vermeulen et al., Nijmegen, Netherlands. In Febs J, May 2015
Interestingly, the RBBP4 and RBBP7 proteins are sensitive to high nonionic detergent concentrations during affinity purification.
Assembly of a comprehensive regulatory network for the mammalian circadian clock: a bioinformatics approach.
Relógio et al., Berlin, Germany. In Plos One, 2014
To validate particular elements in our network, we assessed publicly available ChIP-seq data for BMAL1, REV-ERBα/β and RORα/γ proteins and found strong evidence for circadian regulation of Elavl1, Nme1, Dhx6, Med1 and Rbbp7 all of which are involved in the regulation of tumourigenesis.
Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation.
Rosen et al., Houston, United States. In Plos Genet, 2011
PRC2 complex that includes mPINC and RbAp46 may provide the epigenetic modifications that maintain a progenitor population of mammary epithelial cells committed to an alveolar fate in the pregnant and involuted gland.
Direct conversion of C. elegans germ cells into specific neuron types.
Hobert et al., New York City, United States. In Science, 2011
This reprogramming event requires the removal of the histone chaperone LIN-53 (RbAp46/48 in humans), a component of several histone remodeling and modifying complexes, and this removal can be mimicked by chemical inhibition of histone deacetylases.
Discovery of retinoblastoma-associated binding protein 46 as a novel prognostic marker for distant metastasis in nonsmall cell lung cancer by combined analysis of cancer cell secretome and pleural effusion proteome.
Yu et al., Taiwan. In J Proteome Res, 2009
Both of RbAp46 mRNA and protein levels were upregulated significantly in NSCLC cancer tissues. Serum levels of RbAp46 were markedly higher in NSCLC patients than in healthy controls.
The role of retinoblastoma-associated proteins 46 and 48 in estrogen receptor alpha mediated gene expression.
Nardulli et al., Urbana, United States. In Mol Cell Endocrinol, 2008
Data show that RbAp46 and RbAp48 interact with estrogen receptor (ER)alpha at endogenous, estrogen-responsive genes and alter expression of endogenous, ERalpha-activated and -repressed genes in MCF-7 breast cancer cells.
Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46.
Laue et al., Cambridge, United Kingdom. In Structure, 2008
RbAp46 folds into a seven-bladed beta propeller structure and binds histone H4 in a groove formed between an N-terminal alpha helix and an extended loop inserted into blade six.
Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells.
Songyang et al., Houston, United States. In Nat Cell Biol, 2008
To our surprise, of the various core components in the NuRD complex with which Nanog and Oct4 interact, Mta1 was preferred, whereas Mbd3 and Rbbp7 were either absent or present at sub-stoichiometric levels.
Aberrant expression of X-linked genes RbAp46, Rsk4, and Cldn2 in breast cancer.
Liao et al., Detroit, United States. In Mol Cancer Res, 2007
RT-PCR data show high expression of putative tumor suppressor genes Rsk4 and RbAp46 in 47% and 79% of breast carcinoma cases, respectively, whereas Cldn2 was down-regulated in 52% of breast cancer cases compared with normal adjacent tissues.
Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres.
Yanagida et al., Kyoto, Japan. In Cell, 2004
In contrast, Mis15, Mis16 (strong similarity with human RbAp48 and RbAp46), Mis17, and Mis18 are all part of the CENP-A recruitment pathway.
Histone chaperones, a supporting role in the limelight.
Almouzni et al., Paris, France. In Biochim Biophys Acta, 2004
Finally, we will discuss how the RbAp46/48 proteins, as escort factors, are part of multiple complexes with various functions.
A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product.
Lee et al., San Diego, United States. In Nature, 1991
We report here the identification of one such human cellular Rb-associated protein of relative molecular mass 46,000 (46K) (RbAP46).
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