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RB-associated KRAB zinc finger

RBaK, RB-Associated KRAB zinc finger
This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus. [provided by RefSeq, Mar 2011] (from NCBI)
Top mentioned proteins: p38, miR, MAPK, CGR19, CD30
Papers on RBaK
Unusually effective microRNA targeting within repeat-rich coding regions of mammalian mRNAs.
Berger et al., Cambridge, United States. In Genome Res, 2011
Examples of ORFs targeted by miR-181 include both the well-known tumor suppressor RB1 and RBAK, encoding a C(2)H(2) zinc-finger protein and transcriptional binding partner of RB1.
[Review for the regulatory functions of KRAB zinc finger proteins in embryonic development and tumorgenesis of higher vertebrates].
Jiang et al., Beijing, China. In Yi Chuan, 2010
Studies indicate that data on the regulatory functions of the KRAB-ZFP in embryonic development and tumorgenesis will benefit the understanding of biological roles of KRAB-ZFP in different physiological and pathological states.
Senescent vs. non-senescent cells in the human annulus in vivo: cell harvest with laser capture microdissection and gene expression studies with microarray analysis.
Hanley et al., Charlotte, United States. In Bmc Biotechnol, 2009
Genes with established relationships to senescence were found to be significantly upregulated in senescent cells vs. non-senescent cells: p38 (MPAK14), RB-Associated KRAB zinc finger, Discoidin, CUB and LCCL domain, growth arrest and DNA-damage inducible beta, p28ING5, sphingosine-1-phosphate receptor 2 and somatostatin receptor 3; cyclin-dependent kinase 8 showed significant downregulation in senescent cells.
Exploring the 7p22.1 chromosome as a candidate region for autism.
M'rad et al., Tunisia. In J Biomed Biotechnol, 2009
RBAK, Q6NUR6 also called RNF216L and MMD2).
Examination of chromosome 7p22 candidate genes RBaK, PMS2 and GNA12 in familial hyperaldosteronism type II.
Stowasser et al., Brisbane, Australia. In Clin Exp Pharmacol Physiol, 2008
The role of RBaK, PMS2, and GNA12 in the inheritance of familial hyperaldosteronism type II were studied.
No evidence for coding region mutations in the retinoblastoma-associated Kruppel-associated box protein gene (RBaK) causing familial hyperaldosteronism type II.
Stowasser et al., In Clin Endocrinol (oxf), 2006
study found no evidence of mutations in the coding sequence and splice sites of RBaK in association with familial hyperaldosteronism type II
ZNF325, a novel human zinc finger protein with a RBaK-like RB-binding domain, inhibits AP-1- and SRE-mediated transcriptional activity.
Li et al., Changsha, China. In Biochem Biophys Res Commun, 2006
Here, we have identified a novel human zinc-finger transcriptional repressor, ZNF325, that contains a RBaK-like RB-binding domain and 15 tandem repeated C2H2 type zinc fingers.
The retinoblastoma protein-associated transcription repressor RBaK interacts with the androgen receptor and enhances its transcriptional activity.
Heyns et al., Leuven, Belgium. In J Mol Endocrinol, 2003
RBaK interacts with the androgen receptor and increases its transcriptional activity.
Novel transcription factors in human CD34 antigen-positive hematopoietic cells.
Westbrook et al., Chicago, United States. In Blood, 2002
Novel transcription factors identified in human CD34 antigen-positive hematopoietic stem cells.
Cloning and characterization of a novel Kruppel-associated box family transcriptional repressor that interacts with the retinoblastoma gene product, RB.
Lee et al., San Antonio, United States. In J Biol Chem, 2000
The mouse and human forms of the novel RB-associated KRAB protein (RBaK) are widely expressed.
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