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Ring finger protein 40

Rb-associated protein, RNF40, a Rb-associated protein, STARING, RBP95
The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: Histone, Ubiquitin, Bre1, CAN, RbAp46
Papers on Rb-associated protein
TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage.
Kim et al., Suwŏn, South Korea. In Nat Commun, Dec 2015
Biochemical analysis reveals that the N terminus of TRAIP is crucial for RAP80 interaction, while the C terminus of TRAIP is required for TRAIP localization to sites of DNA damage through a direct interaction with RNF20-RNF40.
Structure of the yeast Bre1 RING domain.
Wolberger et al., Baltimore, United States. In Proteins, Jun 2015
Homology modeling suggests that the human homologue of Bre1, RNF20/RNF40, heterodimerizes through similar coiled-coil interactions.
Histone H2B monoubiquitination: roles to play in human malignancy.
Marsh et al., Sydney, Australia. In Endocr Relat Cancer, Feb 2015
The H2Bub1 enzymatic cascade involves E3 RING finger ubiquitin ligases, with the main E3 generally accepted to be the RNF20-RNF40 complex, and deubiquitinases including ubiquitin-specific protease 7 (USP7), USP22 and USP44.
SUPT6H controls estrogen receptor activity and cellular differentiation by multiple epigenomic mechanisms.
Johnsen et al., Hamburg, Germany. In Oncogene, Feb 2015
We show that SUPT6H is required for estrogen-regulated transcription and the maintenance of chromatin structure in breast cancer cells, possibly in part through interaction with RNF40 and regulation of histone H2B monoubiquitination (H2Bub1).
Arsenite binds to the RING finger domains of RNF20-RNF40 histone E3 ubiquitin ligase and inhibits DNA double-strand break repair.
Wang et al., Riverside, United States. In J Am Chem Soc, 2014
Core histones can be ubiquitinated by RING finger E3 ubiquitin ligases, among which the RNF20-RNF40 heterodimer catalyzes the ubiquitination of histone H2B at lysine 120.
The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination.
Yao et al., Fort Collins, United States. In J Biol Chem, 2014
In the nucleus, Usp15 indirectly associates with the ubH2B E3 ligase, RNF20/RNF40, and directly associates with a component of the splicing machinery, SART3 (also known as TIP110 or p110).
R-loops and genomic instability in Bre1 (RNF20/40)-deficient cells.
Brown et al., Stanford, United States. In Cell Cycle, 2012
We have proposed that maintenance of genomic stability may constitute the basis for the tumor-suppressing activity of the Bre1 (RNF20/RNF40) complex.
The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cells.
Johnsen et al., Göttingen, Germany. In Mol Cell, 2012
Furthermore, the H2B ubiquitin ligase RNF40 is required for the induction of differentiation markers and transcriptional reprogramming of hMSCs.
Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability.
Brown et al., Stanford, United States. In Cancer Res, 2012
We show that Bre1 (human BRE1A/B (RNF20/40) and mouse Bre1a/b (Rnf20/40)) acts as an important suppressor of chromosomal instability
Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth.
Palvimo et al., Kuopio, Finland. In Mol Cell Endocrinol, 2012
our results suggest that RNF20 and RNF40, either via ubiquitylation of H2B or other targets, are coupled to the proliferation of prostate cancer cells.
The tumor suppressor CDC73 interacts with the ring finger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B monoubiquitination.
Marsh et al., Sydney, Australia. In Hum Mol Genet, 2012
Using CDC73 as bait in a yeast two-hybrid assay, we identified the ring finger proteins RNF20 and RNF40 as binding partners of this tumor suppressor.
The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair.
Johnsen et al., Göttingen, Germany. In Cell Cycle, 2011
RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair.
RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response.
Oren et al., Tel Aviv-Yafo, Israel. In Febs Lett, 2011
Studies indicate that H2B monoubiquitylation is driven primarily by an E3 ubiquitin ligase composed of the two RING finger proteins RNF20 and RNF40.
Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cells.
Brown et al., Stanford, United States. In Radiat Res, 2010
the observed defects in the radiation response of Bre1a/b-deficient cells
Cellular signaling in normal and cancerous stem cells.
Wernet et al., Düsseldorf, Germany. In Cell Signal, 2007
Nucleolin, an Rb-associated protein, is abundant in proliferating cancerous cells and likely contributes to the maintenance of human CD34-positive stem/progenitor cells of hematopoiesis.
Endoluminal therapies for gastro-oesophageal reflux disease.
Bruley des Varannes et al., Nantes, France. In Lancet, 2003
STARING POINT: Two prospective open-label studies have recently reported 1-year follow-up of GORD patients treated either by radiofrequency-energy delivery (G Triadafilopoulos and colleagues Gastrointest Endosc 2002; 55:149-56) or endoscopic suturing (Z Mahmood and colleagues Gut 2003; 52:34-39).
A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product.
Lee et al., San Diego, United States. In Nature, 1991
We report here the identification of one such human cellular Rb-associated protein of relative molecular mass 46,000 (46K) (RbAP46).
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