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Retinoic acid receptor, gamma

This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: ACID, RAR, RARbeta, CAN, CIs
Papers on RARgamma
Retinoic acid and androgen receptors combine to achieve tissue specific control of human prostatic transglutaminase expression: a novel regulatory network with broader significance.
Maitland et al., York, United Kingdom. In Nucleic Acids Res, 2012
Evidence that the retinoic acid receptor gamma plays a major role in the regulation of the human prostatic transglutaminase gene.
Spermatogonia differentiation requires retinoic acid receptor γ.
Mark et al., Illkirch-Graffenstaden, France. In Endocrinology, 2012
RARG cell-autonomously transduces, in undifferentiated spermatogonia of adult testes, a RA signal critical for spermatogenesis.
Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1.
Liu et al., United Kingdom. In Proc Natl Acad Sci U S A, 2011
findings demonstrate that signaling through RARs has critical roles in molecular reprogramming and that the synergistic interaction between Rarg and Lrh1 directs reprogramming toward ground-state pluripotency
Retinoic acid receptor γ-dependent signaling cooperates with BMP2 to induce osteoblastic differentiation of C2C12 cells.
Oida et al., Yokohama, Japan. In Connect Tissue Res, 2011
results suggest that a RARgamma-dependent functional crosstalk is present between the retinoic acid and BMP2 signaling to induce osteogenic transdifferentiation in myoblastic C2C12 cells
Detection of variable levels of RARα and RARγ proteins in pluripotent and differentiating mouse embryonal carcinoma and mouse embryonic stem cells.
Asson-Batres et al., Nashville, United States. In Cell Tissue Res, 2011
RARalpha and RARgamma are present in pluripotent and differentiating mEC and mES cells and suggest that the expression of these proteins is dynamic.
Regulation of CD8(+) T cell functions by RARgamma.
He et al., Durham, United States. In Semin Immunol, 2009
Of these receptors, both RARalpha and RARgamma are expressed in T lymphocytes.
Retinoids, rexinoids and their cognate nuclear receptors: character and their role in chemoprevention of selected malignant diseases.
Brtko, Bratislava, Slovakia. In Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2007
Both retinoids and rexinoids are either natural or synthetic compounds related to retinoic acids that act through interaction with two basic types of nuclear receptors belonging to the nuclear receptor superfamily: All-trans retinoic acid receptors (RARalpha, RARbeta, and RARgamma) and retinoid X receptors (RXRalpha, RXRbeta and RXRgamma) as retinoid-inducible transcription factors.
A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency.
Purton et al., Melbourne, Australia. In Cell, 2007
loss of RARgamma results in a nonhematopoietic cell-intrinsic myeloproliferative syndrome, revealing the capability of the microenvironment to be the sole cause of hematopoietic disorders
Role of retinoids and their cognate nuclear receptors in breast cancer chemoprevention.
Brtko, Bratislava, Slovakia. In Cent Eur J Public Health, 2007
Retinoids are natural and synthetic compounds related to retinoic acid that act through interaction with two basic types of nuclear receptors: retinoic acid receptors (RARalpha, RARbeta and RARgamma) and retinoid X receptors (RXRalpha, RXRbeta and RXRgamma) as ligand-activated, DNA-binding, transacting, transcription-modulating proteins involved in a general molecular mechanism responsible for transcriptional responses in target genes.
International Union of Pharmacology. LX. Retinoic acid receptors.
Gronemeyer et al., Strasbourg, France. In Pharmacol Rev, 2006
Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARalpha, RARbeta, and RARgamma), members of the nuclear hormone receptor superfamily.
[Retinoid therapy for autoimmune diseases].
Shudo et al., In Nihon Rinsho Meneki Gakkai Kaishi, 2006
Among them, tamibarotene (Am80) is an RARalpha- and RARbeta-specific (but RARgamma- and RXRs-nonbinding) synthetic retinoid that is effective in the treatment of psoriasis patients and relapsed APL.
Differential expression of nuclear retinoid receptors in normal and malignant prostates.
Kadmon et al., Houston, United States. In J Clin Oncol, 2000
RESULTS: RARalpha, RARgamma, RXRalpha, and RXRgamma mRNAs were detected in most normal and cancerous prostates.
Ultraviolet irradiation of human skin causes functional vitamin A deficiency, preventable by all-trans retinoic acid pre-treatment.
Fisher et al., Ann Arbor, United States. In Nat Med, 1999
We report here that ultraviolet irradiation substantially reduced the mRNA and protein of the two major nuclear retinoid receptors, RAR-gamma and RXR-alpha, in human skin in vivo.
Selective suppression of nuclear retinoic acid receptor beta gene expression in human pancreatic carcinomas.
Lotan et al., Houston, United States. In Int J Oncol, 1996
All four receptors were detected in adjacent normal pancreatic tissue specimens and RAR-alpha, RAR-gamma, and RXR-alpha were also detected in all pancreatic carcinoma specimens.
Additive inhibitory effects of retinoids and interferon-alpha on the growth of human cervical carcinoma cells.
Mitchell et al., Houston, United States. In Int J Oncol, 1996
All the cell lines expressed mRNAs for the nuclear retinoid receptors (RARs and RXRs) RAR-alpha, RAR-gamma, and RXR-alpha, however, RAR-beta mRNA was detected only in ME180, MS751, C4I, and CaSki.
Retinoic Acid receptor-gamma-selective retinoids exert antiproliferative effects on human-melanoma cell-growth in-vitro.
Czarnetzki et al., Antibes, France. In Int J Oncol, 1994
The melanoma cell growth was not affected by most retinoids tested, however, two of the synthetic substances with high RAR-gamma selectivity (CD 437 and CD 2325) showed a dose-dependent antiproliferative effect on all melanoma cell lines tested with IC50 values between 10(-6) and 10(-7) M. A structurally closely related compound, CD 2398, lacking the carboxyl-terminal group and therefore exhibited no RAR-binding did not change melanoma cell growth behaviour.
Distribution of retinoic Acid receptor-alpha, receptor-Beta and receptor-gamma messenger-rnas in neuroblastoma-derived cell-lines and in fresh tumors.
Vidali et al., Genova, Italy. In Int J Oncol, 1994
Each cell line shows a different receptor pattern: RAR alpha mRNA is ubiquitously present, whereas RAR beta and RAR gamma mRNAs are not always expressed.
Aromatic retinoid Acid-derivatives are potent inducers of differentiation of neuroblastoma-cells - structure-function relationship and the involvement of the nuclear retinoic Acid receptors.
Prankerd et al., Brisbane, Australia. In Int J Oncol, 1994
SK-N-SH cell line expressed mRNA transcripts for the nuclear RA receptor-alpha (RARalpha) and did not express the RARbeta or RARgamma receptor.
Expression of the retinoic Acid nuclear receptors (rars) and retinoid x-receptor (rxr) genes in estrogen-receptor positive and negative breast-cancer.
Fontana et al., Baltimore, United States. In Int J Oncol, 1994
RARgamma mRNA is expressed at relatively high levels in a majority of the tumor samples independent of the ER-status while RARbeta mRNA was expressed at low levels in only one tumor sample.
Function of retinoic acid receptor gamma in the mouse.
Chambon et al., Strasbourg, France. In Cell, 1993
Null mutant mice for retinoic acid receptor gamma 2 (RAR gamma 2) or all RAR gamma isoforms were generated.
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