Synthetic lethal targeting of oncogenic transcription factors in acute leukemia by PARP inhibitors.
Hong Kong, Hong Kong. In Nat Med, Dec 2015
Here we demonstrate that AML driven by repressive transcription factors, including AML1-ETO (encoded by the fusion oncogene RUNX1-RUNX1T1) and PML-RARα fusion oncoproteins (encoded by PML-RARA) are extremely sensitive to poly (ADP-ribose) polymerase (PARP) inhibition, in part owing to their suppressed expression of key homologous recombination (HR)-associated genes and their compromised DNA-damage response (DDR).
Genomic landscapes of breast fibroepithelial tumors.
Singapore, Singapore. In Nat Genet, Nov 2015
First, we frequently observed MED12 and RARA mutations in both fibroadenomas and phyllodes tumors, emphasizing the importance of these mutations in fibroepithelial tumorigenesis.