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Importin 5

RanBP5, KPNB3, importin 5, IMP-5, Ran binding protein 5
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: importin, RAN, CAN, MIP, POLYMERASE
Papers on RanBP5
Extending the reservoir of bla IMP-5: the emerging pathogen Acinetobacter bereziniae.
Peixe et al., Porto, Portugal. In Future Microbiol, 2014
RESULTS: Isolates were not clonally related but both produced the 'exclusively Portuguese' IMP-5, with the clinical isolate also producing an OXA-58.
The complex genetic context of blaPER-1 flanked by miniature inverted-repeat transposable elements in Acinetobacter johnsonii.
Zong, Chengdu, China. In Plos One, 2013
The same 439-bp MITEs have also been found flanking class 1 integrons carrying metallo-β-lactamases genes bla IMP-1, bla IMP-5 and bla VIM-2 before but without ISCR1.
Characterizing the normal proteome of human ciliary body.
Pandey et al., Baltimore, United States. In Clin Proteomics, 2012
We identified a number of proteins that were previously not described in the ciliary body including importin 5 (IPO5), atlastin-2 (ATL2), B-cell receptor associated protein 29 (BCAP29), basigin (BSG), calpain-1 (CAPN1), copine 6 (CPNE6), fibulin 1 (FBLN1) and galectin 1 (LGALS1).
IMP-29, a novel IMP-type metallo-β-lactamase in Pseudomonas aeruginosa.
Plésiat et al., Saint-Jean-de-la-Ruelle, France. In Antimicrob Agents Chemother, 2012
IMP-29 was significantly different from the other IMP variants (the closest variant being IMP-5 with 93% amino acid identity).
Specific nuclear localizing sequence directs two myosin isoforms to the cell nucleus in calmodulin-sensitive manner.
Hozák et al., Praha, Czech Republic. In Plos One, 2011
Using pull-down and co-immunoprecipitation assays we identified importin beta, importin 5 and importin 7 as nuclear transport receptors that bind NM1.
Characterization of the interaction between the influenza A virus polymerase subunit PB1 and the host nuclear import factor Ran-binding protein 5.
Fodor et al., Oxford, United Kingdom. In J Gen Virol, 2011
The N-terminal of influenza A virus PB1 mediates its binding to host RanBP5.
Genetic and functional study of the IPO5 gene in schizophrenia.
Wu et al., Changchun, China. In Psychiatry Res, 2011
The results of this study suggested that abnormal expression and alternative splicing of the IPO5 gene may be involved in the pathophysiology of schizophrenia.
Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrap.
Tao et al., West Lafayette, United States. In J Am Soc Mass Spectrom, 2011
Interacting proteins identified include CrkL, BLNK, α- and β-tubulin, Csk, RanBP5 and DJ-1.
Protein biomarkers for in vitro testing of embryotoxicity.
Schrattenholz et al., Mainz, Germany. In J Proteome Res, 2010
Most notably, different responses to cluster 1 and cluster 2 substances were observed for Heat shock protein β-1, Ras-GTPase-activating protein SH3-domain binding protein, Ran binding protein 5, and Calreticulin, Dihydropyrimidinase-like 2 (Ulip2 protein).
Importin β3 mediates the nuclear import of human ribosomal protein L7 through its interaction with the multifaceted basic clusters of L7.
Lin et al., Taipei, Taiwan. In Febs Lett, 2010
importin beta3 is essential for the nuclear import of RPL7. The import is mediated via the multifaceted basic amino acid clusters present in the NH(2)-region of RPL7, and is RanGTP-dependent
Frontotemporal dementia phenotype associated with MAPT gene duplication.
Campion et al., Rouen, France. In J Alzheimers Dis, 2009
locus encompassing the MAPT, IMP5, CRHR1, and STH genes in the index case of a family in which three patients have developed a FTLD phenotype associated with marked memory impairment.
KapI, a non-essential member of the Pse1p/Imp5 karyopherin family, controls colonial and asexual development in Aspergillus nidulans.
Espeso et al., Madrid, Spain. In Microbiology, 2009
Asexual development in the filamentous fungus Aspergillus nidulans is governed by the timely expression and cellular localization of multiple transcription factors.
Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii.
Carter, Hastings, United Kingdom. In Schizophr Bull, 2009
KPNA3 and RANBP5 control the nuclear import of the influenza virus.
Impaired p53 binding to importin: a novel mechanism of cytoplasmic sequestration identified in oxaliplatin-resistant cells.
Fojo et al., Bethesda, United States. In Oncogene, 2009
Impaired p53 binding to importin: a novel mechanism of cytoplasmic sequestration identified in oxaliplatin-resistant cells.
The addition of monosodium glutamate and inosine monophosphate-5 to high-protein meals: effects on satiety, and energy and macronutrient intakes.
Westerterp-Plantenga et al., Maastricht, Netherlands. In Br J Nutr, 2009
In a fed and orally stimulated state, whether the addition of monosodium glutamate (MSG) (alone or in combination with inosine monophosphate-5 (IMP-5)) to a high-protein (HP) meal leads to early satiety and a difference in energy intake at a second course was investigated.
Phenotypic expansion and further characterisation of the 17q21.31 microdeletion syndrome.
Peters et al., In J Med Genet, 2009
Molecular analysis of the deletions demonstrates a critical region spanning 440 kb involving either partially or wholly five genes, CRHR1, IMP5, MAPT, STH, and KIAA1267.
A novel function of karyopherin beta3 associated with apolipoprotein A-I secretion.
Jang et al., Chŏnju, South Korea. In Mol Cells, 2008
These results suggest that karyopherin beta3 plays a crucial role in apo A-I secretion.
PGC7/Stella protects against DNA demethylation in early embryogenesis.
Nakano et al., Ōsaka, Japan. In Nat Cell Biol, 2007
After determining that PGC7/Stella binds to Ran binding protein 5 (RanBP5; a nuclear transport shuttle protein), mutant versions of the two proteins were used to examine exactly when and where PGC7/Stella functions within the cell.
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