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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

RAN, member RAS oncogene family

RAN, Ran GTPase, GTPase Ran, TC4
RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, importin, RCC1, RanGAP1, V1a
Papers on RAN
The GTPase RAN regulates multiple steps of the centrosome life cycle.
Lavia, Roma, Italy. In Chromosome Res, Feb 2016
UNASSIGNED: Growing lines of evidence implicate the small GTPase RAN, its regulators and effectors-predominantly, nuclear transport receptors-in practically all aspects of centrosome biology in mammalian cells.
A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.
Görlich et al., Göttingen, Germany. In Elife, Jan 2016
UNASSIGNED: CRM1 is a highly conserved, RanGTPase-driven exportin that caries proteins and RNPs from the nucleus to the cytoplasm.
Rev7/Mad2B plays a critical role in the assembly of a functional mitotic spindle.
Xiao et al., Canada. In Cell Cycle, Jan 2016
Our data therefore suggest that besides its role in APC/C(Cdh1) inhibition, Rev7 is also required for mitotic spindle organization and faithful chromosome segregation most probably through its physical interaction with RAN.
Nesprin-2 mediated nuclear trafficking and its clinical implications.
Noegel et al., Köln, Germany. In Nucleus, Jan 2016
We show that their nuclear transport is unlikely due to the canonical RAN mediated nuclear import, but rather to a RAN independent Ca(2+)/Calmodulin driven mechanism involving Nesprin-2.
A LIN28B-RAN-AURKA Signaling Network Promotes Neuroblastoma Tumorigenesis.
Diskin et al., Philadelphia, United States. In Cancer Cell, Dec 2015
Here, we identify the oncogene RAN as a LIN28B target and show regional gain of chromosome 12q24 as an additional somatic alteration resulting in increased RAN expression.
GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport.
Taylor et al., Memphis, United States. In Nature, Oct 2015
To elucidate the consequences of G4C2 repeat expansion in a tractable genetic system, we generated transgenic fly lines expressing 8, 28 or 58 G4C2-repeat-containing transcripts that do not have a translation start site (AUG) but contain an open-reading frame for green fluorescent protein to detect repeat-associated non-AUG (RAN) translation.
Invited review: decoding the pathophysiological mechanisms that underlie RNA dysregulation in neurodegenerative disorders: a review of the current state of the art.
Hautbergue et al., Sheffield, United Kingdom. In Neuropathol Appl Neurobiol, Feb 2015
Genetic mutations that cause neurodegenerative disorders disrupt healthy gene expression at diverse levels, from chromatin remodelling, transcription, splicing, through to axonal transport and repeat-associated non-ATG (RAN) translation.
The Ran Pathway in Drosophila melanogaster Mitosis.
Wakefield et al., Exeter, United Kingdom. In Front Cell Dev Biol, 2014
Over the last two decades, the small GTPase Ran has emerged as a central regulator of both mitosis and meiosis, particularly in the generation, maintenance, and regulation of the microtubule (MT)-based bipolar spindle.
Association of Polymorphic Variants of miRNA Processing Genes with Larynx Cancer Risk in a Polish Population.
Majsterek et al., Warsaw, Poland. In Biomed Res Int, 2014
Nine polymorphisms of pre-miRNA processing genes, DROSHA (rs6877842), DGCR8 (rs3757, rs417309, and rs1640299), RAN (rs14035), XPO5 (rs11077), DICER1 (rs13078 and rs3742330) and TARBP2 (rs784567), were performed by TaqMan SNP Genotyping Assay.
RAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disorders.
Krzyzosiak et al., Poznań, Poland. In Nucleic Acids Res, 2014
The boundary between such classifications has recently been blurred by the discovery of repeat-associated non-AUG (RAN) translation reported in spinocerebellar ataxia type 8, myotonic dystrophy type 1, fragile X tremor/ataxia syndrome and C9ORF72 amyotrophic lateral sclerosis and frontotemporal dementia.
Towards understanding RNA-mediated neurological disorders.
Jin et al., Changsha, China. In J Genet Genomics, 2014
We focus on diseases with aberrant sequestration of RNA-binding proteins, bi-directional transcription, aberrant translation of repeat expansion RNA transcripts (repeat-associated non-ATG (RAN) translation), and the formation of pathological RNA:DNA secondary structure (R-loop).
RNA-binding protein misregulation in microsatellite expansion disorders.
Swanson et al., Gainesville, United States. In Adv Exp Med Biol, 2013
Efforts to understand the molecular basis of these disorders has already uncovered novel pathogenic mechanisms, including RNA toxicity and repeat-associated non-ATG (RAN) translation, and current studies suggest that additional surprising insights into cellular regulatory pathways will emerge in the future.
Characterization of a novel activated Ran GTPase mutant and its ability to induce cellular transformation.
Cerione et al., Ithaca, United States. In J Biol Chem, 2012
a novel connection between the hyper-activation of the small GTPase Ran and the matricellular protein SMOC-2 that has important consequences for oncogenic transformation.
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
A size-exclusion permeability barrier and nucleoporins characterize a ciliary pore complex that regulates transport into cilia.
Verhey et al., Ann Arbor, United States. In Nat Cell Biol, 2012
Recent work demonstrated that components of the nuclear import machinery, including the Ran GTPase and importins, regulate ciliary entry.
Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways.
El-Tanani et al., Belfast, United Kingdom. In Clin Cancer Res, 2012
Overexpression of Ran in clinical specimens is significantly associated with poor patient outcome in both breast and lung cancers.
RanGTP is required for meiotic spindle organization and the initiation of embryonic development in Drosophila.
McKim et al., United States. In J Cell Sci, 2011
RanGTP is required for meiotic spindle organization and the initiation of embryonic development.
Essential role of the small GTPase Ran in postnatal pancreatic islet development.
Altieri et al., Philadelphia, United States. In Plos One, 2010
Loss of ran GTP-Binding Protein is associated with overt diabetes, with hyperglycemia, reduced insulin production, and nearly complete loss of islet number and islet mass.
Structure of RCC1 chromatin factor bound to the nucleosome core particle.
Tan et al., United States. In Nature, 2010
The small GTPase Ran enzyme regulates critical eukaryotic cellular functions including nuclear transport and mitosis through the creation of a RanGTP gradient around the chromosomes.
Selectivity mechanism of the nuclear pore complex characterized by single cargo tracking.
Liphardt et al., Berkeley, United States. In Nature, 2010
Without Ran GTPase, a critical regulator of transport directionality, cargos still explore the entire NPC, but have a markedly reduced probability of exit into the nucleus, suggesting that NPC entry and exit steps are not equivalent and that the pore is functionally asymmetric to importing cargos.
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