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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

V-ral simian leukemia viral oncogene homolog A

Ral, RalA
The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, Raf, HAD, Akt
Papers using Ral antibodies
Prediction of the virological response to etravirine in clinical practice: Comparison of three genotype algorithms
Wainberg Mark A et al., In Retrovirology, 2008
... RAL and MK-2048 were obtained from Merck Pharmaceuticals, Inc ...
The determination of raloxifene in rat tissue using HPLC
Reuss Bernhard et al., In Cell Biology and Toxicology, 2006
... Stock solutions of either TAM, RAL, or RA were prepared in cell culture grade dimethylsulfoxide (DMSO,
Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion
Philips Mark R. et al., In The Journal of Cell Biology, 1997
... the relevant human cDNAs (Ras isoforms or mutants thereof, Rap1 or mutants thereof, Raf-1, and Ral GDS) were amplified by PCR and cloned in frame into the mammalian expression vectors pEGFP-N1 or pEGFP-C3 (CLONTECH Laboratories, Inc.) or into ...
Papers on Ral
Development of liquid chromatography-tandem mass spectrometry methods for the quantitation of Anisakis simplex proteins in fish.
Christians et al., Oslo, Norway. In J Chromatogr A, Feb 2016
Both, the label-free semi-quantitative nLC-nESI-Orbitrap-MS/MS (MS1) and the heavy peptide-applying absolute-quantitative (AQUA) LC-TripleQ-MS/MS (MS2) use unique reporter peptides derived from anisakid hemoglobin and SXP/RAL-2 protein as analytes.
Mucosal tissue pharmacokinetics of the integrase inhibitor raltegravir in a humanized mouse model: Implications for HIV pre-exposure prophylaxis.
Akkina et al., Fort Collins, United States. In Virology, Feb 2016
Here we employed a humanized mouse model to derive comprehensive PK data on the HIV integrase inhibitor raltegravir (RAL), a leading PrEP drug candidate.
Could in-vitro studies on Ishikawa cell lines explain the endometrial safety of raloxifene? Systematic literature review and starting points for future oncological research.
Nardelli et al., Padova, Italy. In Eur J Cancer Prev, Nov 2015
To evaluate all the in-vitro raloxifene (RAL) mechanisms of action on normal, Ishikawa, and different endometrium-derived cell lines to explain the in-vivo RAL endometrial effects, a systematic literature search was performed in the electronic databases MEDLINE, EMBASE ScienceDirect, and the Cochrane Library for the time period between 2002 and 2012.
Pleiotropic effects of statins.
Vasnawala et al., India. In Indian J Endocrinol Metab, Sep 2015
These isoprenoid intermediates are required for activation of various intracellular/signaling proteins- small guanosine triphosphate bound protein Ras and Ras-like proteins like Rho, Rab, Rac, Ral, or Rap which plays an indispensible role in multiple cellular processes.
Ral GTPases: crucial mediators of exocytosis and tumourigenesis.
Horiuchi et al., Sendai, Japan. In J Biochem, May 2015
The Ral guanosine triphosphatases (GTPases), RalA and RalB, are members of the Ras superfamily of small GTPases.
The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer.
Theodorescu et al., Aurora, United States. In Acta Pharmacol Sin, Mar 2015
The RAL GTPase family comprises RALA and RALB, which can have either divergent or similar functions in different tumor models.
Development of polymeric-cationic peptide composite nanoparticles, a nanoparticle-in-nanoparticle system for controlled gene delivery.
Kett et al., Belfast, United Kingdom. In Int J Nanomedicine, 2014
The cationic cell-penetrating peptide RALA was used to condense DNA into nanoparticles that were encapsulated within a range of PLA-PEG copolymers.
Cost-Effectiveness of Dolutegravir in HIV-1 Treatment-Experienced (TE) Patients in France.
Aubin et al., Paris, France. In Plos One, 2014
OBJECTIVES: To evaluate the cost-effectiveness of a new generation integrase inhibitor (INI), dolutegravir (DTG), in France, in treatment-experienced (TE) and INI-naïve HIV-infected adults with at least two classes resistance compared to raltegravir (RAL), by adapting previously published Anti-Retroviral Analysis by Monte Carlo Individual Simulation (ARAMIS) model.
Discovery and characterization of small molecules that target the GTPase Ral.
Theodorescu et al., Aurora, United States. In Nature, 2014
The Ras-like GTPases RalA and RalB are important drivers of tumour growth and metastasis.
The role of prostaglandin E2 in renal cell cancer development: future implications for prognosis and therapy.
Czarnecka et al., Warsaw, Poland. In Future Oncol, 2014
PGE2 was shown to activate Akt/RGC2/RalA signaling cascade in RCC cells.
The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.
Sablina et al., Leuven, Belgium. In Nat Cell Biol, 2013
How this differential interaction is achieved molecularly by the RAL GTPase remains unknown.
RalA and RalB proteins are ubiquitinated GTPases, and ubiquitinated RalA increases lipid raft exposure at the plasma membrane.
Camonis et al., Paris, France. In J Biol Chem, 2012
the existence of an ubiquitination/de-ubiquitination cycle superimposed on the GDP/GTP cycle of RalA, involved in the regulation of RalA activity as well as in membrane raft trafficking.
Inhibition of small GTPase RalA regulates growth and arsenic-induced apoptosis in chronic myeloid leukemia (CML) cells.
Fei et al., Guangzhou, China. In Cell Signal, 2012
This study detected RALA level in Chronic myelogenous leukemia cells, which is highly expressed and distributed mainly in the cytoplasm and/or partially in endomembrane.
RalA and RalB differentially regulate development of epithelial tight junctions.
Yeaman et al., Iowa City, United States. In Mol Biol Cell, 2011
RalA and RalB differentially regulate development of epithelial tight junctions.
miR-181a post-transcriptionally downregulates oncogenic RalA and contributes to growth inhibition and apoptosis in chronic myelogenous leukemia (CML).
Luo et al., Guangzhou, China. In Plos One, 2011
RalA is directly regulated by miR-181a and plays an important role in CML.
The Rap1-Rgl-Ral signaling network regulates neuroblast cortical polarity and spindle orientation.
Speicher et al., Alacant, Spain. In J Cell Biol, 2011
the Rap1-Rgl-Ral signaling network is a novel mechanism that cooperates with other intrinsic polarity cues to modulate asymmetric neuroblast division
Coupling mitochondrial and cell division.
Youle et al., In Nat Cell Biol, 2011
Two mitotic kinases, the cyclin B-CDK1 complex and Aurora A, are now shown to cooperate with the small G protein RALA and its effector RALBP1 to promote DRP1 phosphorylation and mitochondrial fission.
RALA and RALBP1 regulate mitochondrial fission at mitosis.
Counter et al., Durham, United States. In Nat Cell Biol, 2011
Data show that disrupting either RALA or RALBP1 leads to a loss of mitochondrial fission at mitosis, improper segregation of mitochondria during cytokinesis and a decrease in ATP levels and cell number.
Exocyst function is regulated by effector phosphorylation.
Saltiel et al., Ann Arbor, United States. In Nat Cell Biol, 2011
The G protein RalA resides on Glut4 vesicles, and binds to the exocyst after activation by insulin, but must then disengage to ensure continuous exocytosis.
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