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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Protein phosphatase 1, regulatory subunit 13 like

IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, CD38, ZAP-70
Papers on Rai
Robust Thyroid Gene Expression and Radioiodine Uptake Induced by Simultaneous Suppression of BRAF V600E and Histone Deacetylase in Thyroid Cancer Cells.
Xing et al., Baltimore, United States. In J Clin Endocrinol Metab, Feb 2016
UNASSIGNED: Context Use of BRAF V600E inhibitors to restore thyroid iodide-handing gene expression and radioactive iodine (RAI) avidity is an attractive therapeutic strategy for RAI-refractory thyroid cancer, but recent initial clinical responses were modest.
Lenvatinib: Role in thyroid cancer and other solid tumors.
Habra et al., Houston, United States. In Cancer Treat Rev, Jan 2016
Lenvatinib is approved for treatment of locally recurrent or metastatic, progressive, radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC).
Impaired immune regulation after radioiodine therapy for Graves' disease and the protective effect of Methimazole.
Rottembourg et al., Sherbrooke, Canada. In Endocrine, Jan 2016
UNASSIGNED: Both therapies for Graves' disease (GD), radioactive iodine (RAI) and antithyroid drugs (ATD), were reported to have specific immune effects.
Comparison of Antagonist Muscle Activity During Walking Between Total Knee Replacement and Control Subjects Using Unnormalized Electromyography.
Wimmer et al., Chicago, United States. In J Arthroplasty, Jan 2016
We developed a relative activation index (RAI) to compare leg muscle activity from unnormalized surface electromyography (sEMG) between TKR and control subjects.
Selective inhibitors of aurora kinases inhibit proliferation, reduce cell viability and impair cell cycle progression in papillary thyroid carcinoma cells.
Ulisse et al., Roma, Italy. In J Biol Regul Homeost Agents, Oct 2015
In the present study, we sought to establish whether Aurora kinase inhibition could be of any therapeutic value in the treatment of aggressive forms of PTC, enduring to radioactive iodide (RAI) ablation.
Encapsulated Thyroid Carcinoma of Follicular Cell Origin.
Ghossein et al., New York City, United States. In Endocr Pathol, Sep 2015
EHC appear to recur earlier, are less RAI avid, and have a different mutation profile than EFC.
Sorafenib: a review of its use in patients with radioactive iodine-refractory, metastatic differentiated thyroid carcinoma.
Plosker et al., Auckland, New Zealand. In Target Oncol, Mar 2015
Sorafenib (Nexavar®) is the first tyrosine kinase inhibitor to be approved for the treatment of radioactive iodine (RAI)-refractory differentiated thyroid carcinoma (DTC).
Cabozantinib in Thyroid Cancer.
Antonelli et al., Pisa, Italy. In Recent Pat Anticancer Drug Discov, 2014
Actually, two Phase II trials of cabozantinib in DTC patients resistant to RAI are ongoing.
New therapies for dedifferentiated papillary thyroid cancer.
Antonelli et al., Pisa, Italy. In Int J Mol Sci, 2014
Standard treatment usually includes primary surgery, thyroid-stimulating hormone suppressive therapy, and ablation of the thyroid remnant with radioactive iodine (RAI).
Association between sodium iodide symporter and differentiated Thyroid cancer: a meta-analysis of 9 studies.
Dong et al., Jinan, China. In Int J Clin Exp Med, 2014
CONTEXT: As many studies proved that sodium iodide symporter (NIS) plays a key role in radioactive iodide (RAI) therapy of thyroid cancer, however, a growing number of studies suggests that part of differentiated thyroid carcinomas (DTC) with overexpression of NIS are insensitive to RAI well.
Evolving approaches to patients with advanced differentiated thyroid cancer.
Sherman et al., Aurora, United States. In Endocr Rev, 2013
Advanced differentiated thyroid cancer (DTC), defined by clinical characteristics including gross extrathyroidal invasion, distant metastases, radioiodine (RAI) resistance, and avidity for 18-fluorodeoxyglucose (positron emission tomography-positive), is found in approximately 10-20% of patients with DTC.
iASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes.
Wang et al., Tianjin, China. In Biochem Biophys Res Commun, 2012
These findings showed that iAPSS/iASPPsv reduced the growth inhibition and apoptosis induced by Dex or VP-16, with DNA damage accumulating which might promote the pathogenesis and/or progression of cancer.
iASPP inhibits p53-independent apoptosis by inhibiting transcriptional activity of p63/p73 on promoters of proapoptotic genes.
Liu et al., Chongqing, China. In Apoptosis, 2012
iASPP inhibited apoptosis independently of p53 in tumor cells, mainly by inhibiting the transcriptional activity of p63/p73 on the promoters of proapoptotic genes
Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP.
Wang et al., Dalian, China. In Oncol Rep, 2012
Downregulation of iASPP by siRNA stimulated apoptosis through p53 in two non-small cell lung cancer cell lines
A specific diplotype defined by PPP1R13L rs1970764, CD3EAP rs967591 and ERCC1 rs11615 and lung cancer risk in a Chinese population.
Li et al., Shenyang, China. In Lung Cancer, 2012
variant alleles of PPP1R13L rs1970764 and CD3EAP rs967591 may contribute to risk factors of lung cancer.
Hapmap-based evaluation of ERCC2, PPP1R13L, and ERCC1 and lung cancer risk in a Chinese population.
Sun et al., Shenyang, China. In Environ Mol Mutagen, 2012
Highly significant differential distributions of haplotypes defined by both nine haplotype-tagging SNPs covering ERCC2 and PPP1R13L and fourteen haplotype-tagging SNPs covering ERCC2, PPP1R13L, and ERCC1 were found.
MDM2 SNP309 is associated with poor outcome in B-cell chronic lymphocytic leukemia.
Tinhofer et al., Salzburg, Austria. In J Clin Oncol, 2008
The influence of the heterozygous SNP309 T/G genotype on treatment-free survival depended on the p53 status but not on the CD38, Zap-70, or IgVH mutational status or Rai stage of B-CLL patients.
Abdominal computed tomography predicts progression in patients with Rai stage 0 chronic lymphocytic leukemia.
Montserrat et al., Barcelona, Spain. In J Clin Oncol, 2007
The aim of this study was to analyze the prognostic significance of abdominal CT in patients with CLL in Rai clinical stage 0. PATIENTS AND METHODS: Abdominal CT was performed at diagnosis in 140 patients consecutively diagnosed with CLL in Rai stage 0 disease.
Prospective evaluation of clonal evolution during long-term follow-up of patients with untreated early-stage chronic lymphocytic leukemia.
Dewald et al., Rochester, United States. In J Clin Oncol, 2006
PATIENTS AND METHODS: Between 1994 and 2002, we enrolled 159 patients with previously untreated CLL (83% Rai stage 0/I) on a prospective trial evaluating clonal evolution by FISH.
Richter's syndrome: a report on 39 patients.
Keating et al., Houston, United States. In J Clin Oncol, 1993
Patients at all Rai stages and in complete response (CR) were at risk, including three CR patients with no residual disease at the level of detection by dual-parameter flow cytometry or restriction analysis for immunoglobulin (Ig) gene rearrangements.
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