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RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Radical Fringe
Top mentioned proteins: Lfng, Mfng, HAD, CD4, galectin-1
Papers on Radical Fringe
Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development.
Stanley et al., New York City, United States. In J Immunol, Feb 2016
Lunatic, Manic, and Radical Fringe (LFNG, MFNG, and RFNG) are N-acetylglucosaminyltransferases that modify Notch receptors and regulate Notch signaling.
Fringe controls naïve CD4(+)T cells differentiation through modulating notch signaling in asthmatic rat models.
Guo et al., Shanghai, China. In Plos One, 2011
We found that Radical Fringe (Rfng) was highly expressed, whereas both Lunatic Fringe (Lfng) and Manic Fringe (Mfng) were expressed at low levels.
MFng is dispensable for mouse pancreas development and function.
Edlund et al., Umeå, Sweden. In Mol Cell Biol, 2009
Members of the Fringe family of beta1,3-N-acetylglucosaminyltransferases, Manic Fringe (MFng), Lunatic Fringe (LFng), and Radical Fringe (RFng), modulate Notch signaling, and MFng has been suggested to regulate pancreatic endocrine cell differentiation.
The Notch pathway in ovarian carcinomas and adenomas.
Aebi et al., Bern, Switzerland. In Br J Cancer, 2005
Jagged 2, Delta-like-1, Manic Fringe, and TSL1 were expressed more frequently in adenocarcinomas whereas Deltex, Mastermind, and Radical Fringe were more frequent in adenomas.
Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing.
Favier et al., Grenoble, France. In Bmc Dermatol, 2002
METHODS: By in situ hybridisation, we investigated the in vivo expression of related genes, namely; Notch 1-3, Delta 1, Jagged 1, Lunatic Fringe, Radical Fringe and Manic Fringe during keratinocyte proliferation and differentiation in humans in basal cell carcinoma, psoriasis and in wound healing experiments, compared with normal adult skin.
Differential expression pattern of the three Fringe genes is associated with epidermal differentiation.
Dhouailly et al., Grenoble, France. In J Invest Dermatol, 1998
Therefore, Manic, Lunatic, and Radical Fringe by modulating the Notch pathway may play a key role in defining the different steps of keratinocyte differentiation.
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